Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases

Protein Engineering, Design and Selection

Volumn 21, Issue 5, 2008, Pages 329-341

  Kurtovic, Sanela ^a   Shokeer, Abeer ^a   Mannervik, Bengt ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

DNA shuffling; Glutathione transferase; Multivariate data analysis; Mutant library; Substrate selectivity

Indexed keywords

ALKYLATION; AMINES; AMINO ACIDS; BINDING SITES; BIOCHEMICAL ENGINEERING; CATALYSTS; DECISION MAKING; DNA; ENZYMES; FOOD ADDITIVES; GENES; GENETIC ENGINEERING; MULTIVARIANT ANALYSIS; NUCLEIC ACIDS; ORGANIC ACIDS; PROTEINS; RANDOM VARIABLES; REGRESSION ANALYSIS; SULFUR COMPOUNDS; TECHNOLOGY;

ACTIVE SITES; ALKYL IODIDES; AMINO ACID RESIDUES; CATALYTIC ACTIVITIES; DESCRIPTORS; DNA SHUFFLING; FUNCTIONAL PROPERTIES; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASES; ISOLATED MUTANTS; MULTI-VARIATE ANALYSIS; MULTIVARIATE DATA ANALYSIS; MUTANT LIBRARY; NATURAL ENZYMES; NOVEL FUNCTIONS; PROTEIN ENGINEERING; SPECIFIC ACTIVITY; SUBSTRATE SELECTIVITY; SUBSTRATE SPECIFICITY; SUBSTRATE-BINDING;

SUBSTRATES;

ALKANE DERIVATIVE; GLUTATHIONE TRANSFERASE; IODIDE; ALKANE; AMINO ACID;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; DNA SHUFFLING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME SUBSTRATE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; RAT; SEQUENCE ALIGNMENT; CALORIMETRY; CHEMISTRY; CONFORMATION; ENZYME SPECIFICITY; METABOLISM; METHODOLOGY; MOLECULAR GENETICS; MULTIVARIATE ANALYSIS; MUTATION; SEQUENCE HOMOLOGY; STEREOISOMERISM;

BOVINAE; RATTUS;

ALKANES; AMINO ACID SEQUENCE; AMINO ACIDS; CALORIMETRY; CATALYSIS; GLUTATHIONE TRANSFERASE; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MULTIVARIATE ANALYSIS; MUTATION; PROTEIN ENGINEERING; SEQUENCE HOMOLOGY, AMINO ACID; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 48849110424     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzn010     Document Type: Article

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