Time-course changes of hematology and clinical chemistry values in pregnant rats

Journal of Toxicological Sciences

Volumn 33, Issue 3, 2008, Pages 375-380

  Honda, Tatsuya ^a   Honda, Katsuya ^a   Kokubun, Chisato ^a   Nishimura, Tomonari ^a   Hasegawa, Mina ^a   Nishida, Atsuyuki ^a   Inui, Toshihide ^a   Kitamura, Kazuyuki ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Clinical chemistry; Hematology; Iron deficiency anemia; Pregnant rat

Indexed keywords

ALBUMIN; CALCIUM; CHLORIDE; CHOLESTEROL; FATTY ACID; FIBRINOGEN; GLOBULIN; GLUCOSE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IRON; PHOSPHATE; PHOSPHOLIPID; PROTEIN; SODIUM; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ARTICLE; BLOOD CHEMISTRY; CHOLESTEROL BLOOD LEVEL; CLINICAL CHEMISTRY; CONTROLLED STUDY; COPULATION; ERYTHROCYTE; FEMALE; HEMATOCRIT; IRON DEFICIENCY ANEMIA; MALE; NEUTROPHIL COUNT; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PREGNANCY; RAT; RETICULOCYTE; SPRAGUE DAWLEY RAT; THROMBOCYTE;

RATTUS;

EID: 48849104981     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.33.375     Document Type: Article

References (21)

1. Baylis, C. (1980): The mechanism of the increase in glomerular filtration rate in the twelve-day pregnant rat. J. Physiol., 305, 405-414.
2. Boehm, O., Zur, B., Koch, A., Tran, N., Freyenhagen, R., Hartmann, M. and Zacharowski, K. (2007): Clinical chemistry reference database for Wistar rats and C57/BL6 mice. Biol. Chem., 388, 547-554.
3. CD(SD)IGS Study Group. (1998-2003): Biological reference data on CD(SD)IGS rats.
4. De Rijk, E.P.C.T., Esch, E.V. and Flik, G. (2002): Pregnancy dating in the rat: Placental morphology and maternal blood parameters. Toxicol. Pathol., 30, 271-282.
5. Fishbane, S., Galgano, C., Langley, R.C.Jr., Canfield, W. and Maesaka, J.K. (1997): Reticulocyte hemoglobin content in the evaluation of iron status of hemodialysis patients. Kidney Int., 52, 217-222.
6. Haram, K., Nilsen, S.T. and Ulvik, R.J. (2001): Iron supplementation in pregnancy - evidence and controversies. Acta. Obstet. Gynecol. Scand., 80, 683-688.
7. ICH harmonized tripartite guideline. (2005): Detection of toxicity to reproduction for medicinal products & toxicity to male fertility (S5(R2)).
8. Jackson, C.W., Steward, S.A., Ashmun, R.A. and McDonald, T.P. (1992): Megakaryocytopoiesis and platelet production are stimulated during late pregnancy and early postpartum in the rat. Blood., 79, 1672-1678.
9. Katoh, M., Ozawa, M., Akima, T., Ikeda, H., Fujii, T. and Ishii, M. (1992): Hematological and serum biochemical changes with age in term fetuses, offspring and dams in normal Sprague-Dawley rats. Jikken Dobutsu, 41, 329-337.
10. Kim, J.C., Yun, H.I., Lim, K.H., Suh, J.E. and Chung, M.K. (2000): Haematological values during normal pregnancy in Sprague-Dawley rats. Comp. Hematol. Int., 10, 74-79.
11. LaBorde, J.B., Wall, K.S., Bolon, B., Kumpe, T.S., Patton, R., Zheng, Q., Kodell, R. and Young, J.F. (1999): Haematology and serum chemistry parameters of the pregnant rat. Lab. Anim., 33, 275-287.
12. Liberati, T.A., Sansone, S.R. and Feuston, M.H. (2004): Hematology and clinical chemistry values in pregnant Wistar Hannover rats compared with nonmated controls. Vet. Clin. Pathol., 33, 68-73.
13. Lind, T. (1980): Clinical chemistry of pregnancy. In Advances in Clinical Chemistry. Vol. 21, pp. 1-24 (Lantner, A. and Schwartz, M.), Academic Press Inc., London.
14. Lurie, S. and Danon, D. (1992): Life span of erythrocytes in late pregnancy. Obstet. Gynecol., 80, 123-126.
15. Matsuzawa, T., Nomura, M. and Unno, T. (1993): Clinical pathology reference ranges of laboratory animals. Working Group II, Nonclinical Safety Evaluation Subcommittee of the Japan Pharmaceutical Manufacturers Association. J. Vet. Med. Sci., 55, 351-362.
16. Papworth, T.A. and Clubb, S.K. (1995): Clinical pathology in the female rat during the pre- and postnatal period. Comp. Hematol. Int., 5, 13-24.
17. Petterino, C. and Argentino-Storino, A. (2006): Clinical chemistry and haematology historical data in control Sprague-Dawley rats from pre-clinical toxicity studies. Exp. Toxicol. Pathol., 57, 213-219.
18. Pitkin, R.M. (1985): Calcium metabolism in pregnancy and the perinatal period: a review. Am J Obstet Gynecol., 151, 99-109.
19. Watney, P.J. and Rudd, B.T. (1974): Calcium metabolism in pregnancy and in the newborn. J. Obstet. Gynaecol. Br. Commonw., 81, 210-219.
20. Wells, M.Y., Decobecq, C.P.M., Decouvelaere, D.M., Justice, C. and Guittin, P. (1999): Changes in clinical pathology parameters during gestation in the New Zealand White rabbit. Toxicol. Pathol., 27, 370-379.
21. Yang, J.J., Krueger, A.J., Roy, T.A. and Feuston, M.H. (1988): Serum chemistry assays in reproduction toxicity testing. Clin. Chem., 34, 181.