Tumor risk assessment by means of immunocytochemical detection of early pre-malignant changes in buccal smears

Oncology Reports

Volumn 19, Issue 6, 2008, Pages 1373-1379

  Bloching, Marc M ^a   Soulsby, Hannah ^b   Naumann, Andreas ^a   Aust, Wolfram ^a   Merkel, Daniel ^a   Braun, Theresa ^a   Naim, Ramin ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Buccal smears; Field cancerization; Head neck squamous cell carcinoma; Malignant; Prevention; Risk assessment; Tumor

Indexed keywords

CYCLIN D1; CYCLINE; KI 67 ANTIGEN; PROTEIN P53; CYCLIN D; TP53 PROTEIN, HUMAN; TUMOR MARKER; TUMOR PROTEIN;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CANCER RISK; CANCER SCREENING; CELL NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE MARKER; EARLY CANCER; FEMALE; HIGH RISK BEHAVIOR; HIGH RISK PATIENT; HUMAN; HUMAN CELL; HYPOPHARYNX CARCINOMA; IMMUNOCYTOCHEMISTRY; LARYNX CARCINOMA; MALE; MORBIDITY; MOUTH CANCER; ONCOGENE; ORAL BIOPSY; OROPHARYNX CARCINOMA; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK ASSESSMENT; SMOKING; TUMOR SUPPRESSOR GENE; HYPOPHARYNX TUMOR; LARYNX TUMOR; METABOLISM; MIDDLE AGED; MOUTH MUCOSA; OROPHARYNX TUMOR; PATHOLOGY; PROGNOSIS; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CYCLINS; FEMALE; HUMANS; HYPOPHARYNGEAL NEOPLASMS; KI-67 ANTIGEN; LARYNGEAL NEOPLASMS; MALE; MIDDLE AGED; MOUTH MUCOSA; NEOPLASM PROTEINS; OROPHARYNGEAL NEOPLASMS; PRECANCEROUS CONDITIONS; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; RISK ASSESSMENT; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 48849103280     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Boyle P, Macfarlane GJ, Blot WJ, Chiesa F, Lefebvre JL, Azul AM, De Vries N and Scully C: European School of Oncology Advisory report to the European Commission for the Europe Against Cancer Programme: oral carcinogenesis in Europe. Eur J Cancer B Oral Oncol 31: 75-85, 1995.
2. Haas JF, Rahu M and Staneczek W: Time trends in cancer incidence in the German Democratic Republic 1968-1981. Neoplasma 33: 129-139, 1986.
3. La Vecchia C, Tavani A, Franceschi S, Levi F, Corrao G and Negri E: Epidemiology and prevention of oral cancer. Oral Oncol 33: 302-312, 1997.
4. Bootz F: Reports from the Aachen annual meeting of the German Society for ENT Medicine, Head and Neck Surgery. Oncology-Ear Surgery. HNO 47: 859-862, 1999.
5. Ambrosch P: Screening studies for early detection of carcinomas of the upper aerodigestive tract. HNO 44: 609-611, 1996.
6. Slaughter DP, Southwick HW and Smejkal W: Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 6: 963-968, 1953.
7. Weinberg RA: How cancer arises. Sci Am 275: 62-70, 1996.
8. Carrano AV and Natarajan AT: International Commission for Protection Against Environmental Mutagens and Carcinogens. ICPEMC publication no. 14. Considerations for population monitoring using cytogenetic techniques. Mutat Res 204: 379-406, 1988.
9. Anders A, Groger H, Anders F, Zechel C, Smith A and Schlatterer B: Discrimination of initiating and promoting carcinogens in fish. Ann Rech Vet 22: 273-294, 1991.
10. Anders A, Zechel C, Schlatterer B, Groger H, Schmidt D, Smith A and Anders F: Genetic and molecular approach for breeding and use of laboratory fish for the detection of agents with carcinogenic and/or promoting activity. Bull Cancer 78: 415-433, 1991.
11. Cohen SM and Ellwein LB: Genetic errors, cell proliferation, and carcinogenesis. Cancer Res 51: 6493-6505, 1991.
12. Renan MJ: How many mutations are required for tumorigenesis? Implications from human cancer data. Mol Carcinog 7: 139-146, 1993.
13. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W and Sidransky D: Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 56: 2488-2492, 1996.
14. Bradford CR, Zhu S, Poore J, Fisher SG, Beals TF, Thoraval D, Hanash SM, Carey TE and Wolf GT: p53 mutation as a prognostic marker in advanced laryngeal carcinoma. Department of Veterans Affairs Laryngeal Cancer Cooperative Study Group. Arch Otolaryngol Head Neck Surg 123: 605-609, 1997.
15. Masuda M, Hirakawa N, Nakashima T, Kuratomi Y and Komiyama S: Cyclin D1 overexpression in primary hypopharyngeal carcinomas. Cancer 78: 390-395, 1996.
16. Mineta H, Borg A, Dictor M, Wahlberg P and Wennerberg J: Correlation between p53 mutation and cyclin D1 amplification in had and neck squamous cell carcinoma. Oral Oncol 33: 42-46, 1997.
17. Mineta H, Miura K, Takebayashi S, Ueda Y, Misawa K, Harada H, Wennerberg J and Dictor M: Cyclin D1 over-expression correlates with poor prognosis in patients with tongue squamous cell carcinoma. Oral Oncol 36: 194-198, 2000.
18. Cohen SM and Ellwein LB: Cell proliferation in carcinogenesis. Science 249: 1007-1011, 1990.
19. Shin DM, Voravud N, Ro JY, Lee JS, Hong WK and Hittelman WN: Sequential increases in proliferating cell nuclear antigen expression in head and neck tumorigenesis: a potential biomarker. J Natl Cancer Inst 85: 971-978, 1993.
20. Schwartz JL, Gu X, Kittles RA, Baptiste A and Shklar G: Experimental oral carcinoma of the tongue and buccal mucosa: possible biologic markers linked to cancers at two anatomic sites. Oral Oncol 36: 225-235, 2000.
21. Bloching M, Hofmann A, Lautenschlager C, Berghaus A and Grummt T: Exfoliative cytology of normal buccal mucosa to predict the relative risk of cancer in the upper aerodigestive tract using the MN-assay. Oral Oncol 36: 550-555, 2000.
22. Piffko J, Bankfalvi A, Joos U, Ofner D, Krassort M and Schmid KW: Immunophenotypic analysis of normal mucosa and squamous cell carcinoma of the oral cavity. Cancer Detect Prev 23: 45-56, 1999.
23. Liu SC and Klein-Szanto AJ: Markers of proliferation in normal and leukoplakic oral epithelia. Oral Oncol 36: 145-151, 2000.
24. Martinez-Lara I, Gonzalez-Moles MA, Ruiz-Avila I, Bravo M, Ramos MC and Fernandez-Martinez JA: Proliferating cell nuclear antigen (PCNA) as a marker of dysplasia in oral mucosa. Acta Stomatol Belg 93: 29-32, 1996.
25. Zain RB, Sakamoto F, Shrestha P and Mori M: Proliferating cell nuclear antigen (PCNA) expression in oral squamous cell carcinoma - an aid to conventional histological grading? Malays J Pathol 17: 23-30, 1995.
26. Prives C and Hall PA: The p53 pathway. J Pathol 187: 112-126, 1999.
27. Bosch FX, Homann N, Conradt C, Dietz A and ETber R: p53 mutations/p53 protein overexpression. Differential significance for the progression of head-neck carcinomas. HNO 47: 833-848, 1999.
28. Ahomadegbe JC, Barrois M, Fogel S, Le Bihan ML, Douc-Rasy S, Duvillard P, Armand JP and Riou G: High incidence of p53 alterations (mutation, deletion, overexpression) in head and neck primary tumors and metastases; absence of correlation with clinical outcome. Frequent protein overexpression in normal epithelium and in early non-invasive lesions. Oncogene 10: 1217-1227, 1995.
29. Ma L, Ronai A, Riede UN and Kohler G: Clinical implication of screening p53 gene mutations in head and neck squamous cell carcinomas. J Cancer Res Clin Oncol 124: 389-396, 1998.
30. Kyomoto R, Kumazawa H, Toda Y, Sakaida N, Okamura A, Iwanaga M, Shintaku M, Yamashita T, Hiai H and Fukumoto M: Cyclin-D1-gene amplification is a more potent prognostic factor than its protein over-expression in human head-and-neck squamous-cell carcinoma. Int J Cancer 74: 576-581, 1997.
31. Bartkova J, Lukas J, Muller H, Strauss M, Gusterson B and Bartek J: Abnormal patterns of D-type cyclin expression and G1 regulation in human head and neck cancer. Cancer Res 55: 949-956, 1995.
32. Friedberg EC, Fuchs RP, Goodman MF, Hanaoka F, Hinkle D, Kunkel TA, Lawrence CW, Livneh Z, Nohmi T, Prakash L, Prakash S, Todo T, Walker GC, Wang Z and Woodgate R: The Y-family of DNA polymerases. Mol Cell 8: 7-8, 2001.
33. Lindahl T, Sedgwick B, Sekiguchi M and Nakabeppu Y: Regulation and expression of the adaptive response to alkylating agents. Annu Rev Biochem 57: 133-157, 1988.
34. Simic MG: Introduction to mechanisms of DNA damage and repair. Basic Life Sci 38: 1-8, 1986.