Second-generation tags for fluorous chemistry exemplified with a new fluorous Mitsunobu reagent

Organic Letters

Volumn 10, Issue 12, 2008, Pages 2453-2456

  Chu, Qianli ^a   Henry, Christopher ^a   Curran, Dennis P ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKENE; AZO COMPOUND; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FLUORINATED HYDROCARBON; PROPYLENE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; SYNTHESIS;

ALKENES; AZO COMPOUNDS; HYDROCARBONS, FLUORINATED; INDICATORS AND REAGENTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 48849088330     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol800750q     Document Type: Article

References (32)

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32. This corresponds to about a 3% weight loading of the cartridge. We attempted a similar experiment with a 5 g cartridge (the size used for the standard Mitsunobo reagent with 26 fluorines), but significant breakthrough (∼20%) of the fluorous products into the organic fraction was observed. Thus, the presence of fewer fluorines in 7p (18 fluorines) must be offset by lower loading in the FSPE.