BCL6 gene amplification/3q27 gain is associated with unique clinicopathological characteristics among follicular lymphoma without BCL2 gene translocation

Modern Pathology

Volumn 21, Issue 8, 2008, Pages 973-978

  Karube, Kennosuke ^a   Ying, Guo ^b   Tagawa, Hiroyuki ^c   Niino, Daisuke ^a   Aoki, Ryosuke ^a   Kimura, Yoshizo ^a   Hashikawa, Keiko ^a   Suefuji, Nobuko ^a   Sugita, Yasuo ^a   Nomura, Yuko ^d   Shimizu, Kay ^a   Yoshida, Shirou ^a   Seto, Masao ^c   Ohshima, Koichi ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

^d FUKUOKA UNIVERSITY   (Japan)

Author keywords

3q27; BCL2; BCL6; Follicular lymphoma; MUM1

Indexed keywords

INTERFERON REGULATORY FACTOR 4;

ARTICLE; BCL6 GENE; CANCER GRADING; CHROMOSOME ANALYSIS; CLINICAL FEATURE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLICULAR LYMPHOMA; GENE; GENE AMPLIFICATION; GENE REARRANGEMENT; GENE TRANSLOCATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MORPHOLOGY; PHENOTYPE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; CHROMOSOME BANDING; CHROMOSOMES, HUMAN, PAIR 3; DNA, NEOPLASM; DNA-BINDING PROTEINS; FEMALE; GENE AMPLIFICATION; GENE REARRANGEMENT; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERFERON REGULATORY FACTORS; LYMPHOMA, FOLLICULAR; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 48749122241     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2008.75     Document Type: Article

References (19)

1. Nathwani BN, Harris NL, Berger F, et al. Follicular lymphoma. In: Jaffe ES, Stein H, Vardiman JW (eds). Pathology and Genetics of Tumours Haematopoietic and Lymphoid Tissues. World Health Organization Classification of Tumours. IARC Press: Lyon, France, 2001, pp 162-167.
2. Hockenbery D, Nunez G, Milliman C, et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-336.
3. Guo Y, Karube K, Kawano R, et al. Low-grade follicular lymphoma with t(14;18) presents a homogeneous disease entity otherwise the rest comprises minor groups of heterogeneous disease entities with Bcl2 amplification, Bcl6 translocation or other gene aberrances. Leukemia 2005;19:1058-1063.
4. Jardin F, Gaulard P, Buchonnet G, et al. Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics. Leukemia 2002;16:2309-2317.
5. Bosga-Bouwer AG, van den Berg A, Haralambieva E, et al. Molecular, cytogenetic, and immunophenotypic characterization of follicular lymphoma grade 3B; a separate entity or part of the spectrum of diffuse large B-cell lymphoma or follicular lymphoma? Hum Pathol 2006;37:528-533.
6. Bosga-Bouwer AG, van Imhoff GW, Boonstra R, et al. Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive. Blood 2003;101:1149-1154.
7. Katzenberger T, Ott G, Klein T, et al. Cytogenetic alterations affecting BCL6 are predominantly found in follicular lymphomas grade 3B with a diffuse large B-cell component. Am J Pathol 2004;165:481-490.
8. Ott G, Katzenberger T, Lohr A, et al. Cytomorphologic, immunohistochemical, and cytogenetic profiles of follicular lymphoma: 2 types of follicular lymphoma grade 3. Blood 2002;99:3806-3812.
9. Horsman DE, Okamoto I, Ludkovski O, et al. Follicular lymphoma lacking the t(14;18)(q32;q21): identification of two disease subtypes. Br J Haematol 2003;120:424-433.
10. Tagawa H, Karube K, Guo Y, et al. Trisomy 3 is a specific genomic aberration of t(14;18) negative follicular lymphoma. Leukemia 2007 21:2549-2551.
11. Karube K, Guo Y, Suzumiya J, et al. CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features. Blood 2007;109:3076-3079.
12. Ohshima K, Kawasaki C, Muta H, et al. CD10 and Bcl10 expression in diffuse large B-cell lymphoma: CD10 is a marker of improved prognosis. Histopathology 2001;39:156-162.
13. Kodama T, Ohshima K, Nomura K, et al. Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa-associated lymphoid tissue lymphoma. Histopathology 2005;47:467-478.
14. Eshoa C, Perkins S, Kampalath B, et al. Decreased CD10 expression in grade III and in interfollicular infiltrates of follicular lymphomas. Am J Clin Pathol 2001;115:862-867.
15. Tsujimoto Y, Ikegaki N, Croce CM. Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma. Oncogene 1987;2:3-7.
16. Chao DT, Korsmeyer SJ. BCL-2 family: regulators of cell death. Annu Rev Immunol 1998;16:395-419.
17. Sekiguchi N, Kobayashi Y, Yokota Y, et al. Follicular lymphoma subgrouping by fluorescence in situ hybridization analysis. Cancer Sci 2005;96:77-82.
18. Ruminy P, Jardin F, Picquenot JM, et al. Two patterns of chromosomal breakpoint locations on the immunoglobulin heavy-chain locus in B-cell lymphomas with t(3;14)(q27;q32): relevance to histology. Oncogene 2006;25:4947-4954.
19. Jardin F, Ruminy P, Bastard C, et al. The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis. Pathol Biol (Paris) 2007;55:73-83.