-
1
-
-
14744299030
-
Regulation of innate immunity by Rho GTPases
-
Bokoch GM: Regulation of innate immunity by Rho GTPases. Trends Cell Biol 2005, 15:163-171
-
(2005)
Trends Cell Biol
, vol.15
, pp. 163-171
-
-
Bokoch, G.M.1
-
2
-
-
0030824832
-
Characterization of RAC3, a novel member of the Rho family
-
Haataja L, Groffen J, Heisterkamp N: Characterization of RAC3, a novel member of the Rho family. J Biol Chem 1997, 272:20384-20388
-
(1997)
J Biol Chem
, vol.272
, pp. 20384-20388
-
-
Haataja, L.1
Groffen, J.2
Heisterkamp, N.3
-
3
-
-
12944284786
-
Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation
-
Ambruso DR, Knall C, Abell AN, Panepinto J, Kurkchubasche A, Thurman G, Gonzalez-Aller C, Hiester A, deBoer M, Harbeck RJ, Oyer R, Johnson GL, Roos D: Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation. Proc Natl Acad Sci USA 2000, 97:4654-4659
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 4654-4659
-
-
Ambruso, D.R.1
Knall, C.2
Abell, A.N.3
Panepinto, J.4
Kurkchubasche, A.5
Thurman, G.6
Gonzalez-Aller, C.7
Hiester, A.8
deBoer, M.9
Harbeck, R.J.10
Oyer, R.11
Johnson, G.L.12
Roos, D.13
-
4
-
-
0035844138
-
Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency
-
Gu Y, Jia B, Yang FC, D'Souza M, Harris CE, Derrow CW, Zheng Y, Williams DA: Biochemical and biological characterization of a human Rac2 GTPase mutant associated with phagocytic immunodeficiency. J Biol Chem 2001, 276:15929-15938
-
(2001)
J Biol Chem
, vol.276
, pp. 15929-15938
-
-
Gu, Y.1
Jia, B.2
Yang, F.C.3
D'Souza, M.4
Harris, C.E.5
Derrow, C.W.6
Zheng, Y.7
Williams, D.A.8
-
5
-
-
0034283717
-
Dominant negative mutation of the hematopoietic- specific Rho GTPase. Rac2, is associated with a human phagocyte immunodeficiency
-
Williams DA, Tao W, Yang F, Kim C, Gu Y, Mansfield P, Levine JE, Petryniak B, Derrow CW, Harris C, Jia B, Zheng Y, Ambruso DR, Lowe JB, Atkinson SJ, Dinauer MC, Boxer L: Dominant negative mutation of the hematopoietic- specific Rho GTPase. Rac2, is associated with a human phagocyte immunodeficiency. Blood 2000, 96:1646-1654
-
(2000)
Blood
, vol.96
, pp. 1646-1654
-
-
Williams, D.A.1
Tao, W.2
Yang, F.3
Kim, C.4
Gu, Y.5
Mansfield, P.6
Levine, J.E.7
Petryniak, B.8
Derrow, C.W.9
Harris, C.10
Jia, B.11
Zheng, Y.12
Ambruso, D.R.13
Lowe, J.B.14
Atkinson, S.J.15
Dinauer, M.C.16
Boxer, L.17
-
6
-
-
0033082165
-
Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense
-
Roberts AW, Kim C, Zhen L, Lowe JB, Kapur R, Petryniak B, Spaetti A, Pollock JD, Borneo JB, Bradford GB, Atkinson SJ, Dinauer MC, Williams DA: Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity 1999, 10:183-196
-
(1999)
Immunity
, vol.10
, pp. 183-196
-
-
Roberts, A.W.1
Kim, C.2
Zhen, L.3
Lowe, J.B.4
Kapur, R.5
Petryniak, B.6
Spaetti, A.7
Pollock, J.D.8
Borneo, J.B.9
Bradford, G.B.10
Atkinson, S.J.11
Dinauer, M.C.12
Williams, D.A.13
-
7
-
-
0035863735
-
Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways
-
Kim C, Dinauer MC: Rac2 is an essential regulator of neutrophil nicotinamide adenine dinucleotide phosphate oxidase activation in response to specific signaling pathways. J Immunol 2001, 166:1223-1232
-
(2001)
J Immunol
, vol.166
, pp. 1223-1232
-
-
Kim, C.1
Dinauer, M.C.2
-
8
-
-
0035826843
-
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
-
USA
-
Yang FC, Atkinson SJ, Gu Y, Borneo JB, Roberts AW, Zheng Y, Pennington J, Williams DA: Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization. Proc Natl Acad Sci USA 2001, 98:5614-5618
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 5614-5618
-
-
Yang, F.C.1
Atkinson, S.J.2
Gu, Y.3
Borneo, J.B.4
Roberts, A.W.5
Zheng, Y.6
Pennington, J.7
Williams, D.A.8
-
9
-
-
0142084736
-
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
-
Gu Y, Filippi MD, Cancelas JA, Siefring JE, Williams EP, Jasti AC, Harris CE, Lee AW, Prabhakar R, Atkinson SJ, Kwiatkowski DJ, Williams DA: Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases. Science 2003, 302:445-449
-
(2003)
Science
, vol.302
, pp. 445-449
-
-
Gu, Y.1
Filippi, M.D.2
Cancelas, J.A.3
Siefring, J.E.4
Williams, E.P.5
Jasti, A.C.6
Harris, C.E.7
Lee, A.W.8
Prabhakar, R.9
Atkinson, S.J.10
Kwiatkowski, D.J.11
Williams, D.A.12
-
10
-
-
18244415152
-
Spontaneous skin ulceration and defective T cell function in CD18 null mice
-
Scharffetter-Kochanek K, Lu H, Norman K, van Nood N, Munoz F, Grabbe S, McArthur M, Lorenzo I, Kaplan S, Ley K, Smith CW, Montgomery CA, Rich S, Beaudet AL: Spontaneous skin ulceration and defective T cell function in CD18 null mice. J Exp Med 1998, 188:119-131
-
(1998)
J Exp Med
, vol.188
, pp. 119-131
-
-
Scharffetter-Kochanek, K.1
Lu, H.2
Norman, K.3
van Nood, N.4
Munoz, F.5
Grabbe, S.6
McArthur, M.7
Lorenzo, I.8
Kaplan, S.9
Ley, K.10
Smith, C.W.11
Montgomery, C.A.12
Rich, S.13
Beaudet, A.L.14
-
11
-
-
0035869535
-
Mechanisms of granulocytosis in the absence of CD18
-
Horwitz BH, Mizgerd JP, Scott ML, Doerschuk CM: Mechanisms of granulocytosis in the absence of CD18. Blood 2001, 97:1578-1583
-
(2001)
Blood
, vol.97
, pp. 1578-1583
-
-
Horwitz, B.H.1
Mizgerd, J.P.2
Scott, M.L.3
Doerschuk, C.M.4
-
12
-
-
0026072892
-
Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells
-
Hestdal K, Ruscetti FW, Ihle JN, Jacobsen SE, Dubois CM, Kopp WC, Longo DL, Keller JR: Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J Immunol 1991, 147:22-28
-
(1991)
J Immunol
, vol.147
, pp. 22-28
-
-
Hestdal, K.1
Ruscetti, F.W.2
Ihle, J.N.3
Jacobsen, S.E.4
Dubois, C.M.5
Kopp, W.C.6
Longo, D.L.7
Keller, J.R.8
-
13
-
-
1842483153
-
Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation
-
Maitra B, Szekely E, Gjini K, Laughlin MJ, Dennis J, Haynesworth SE, Koc ON: Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation. Bone Marrow Transplant 2004, 33:597-604
-
(2004)
Bone Marrow Transplant
, vol.33
, pp. 597-604
-
-
Maitra, B.1
Szekely, E.2
Gjini, K.3
Laughlin, M.J.4
Dennis, J.5
Haynesworth, S.E.6
Koc, O.N.7
-
14
-
-
0036683377
-
Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation
-
Basu S, Hodgson G, Katz M, Dunn AR: Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation. Blood 2002, 100:854-861
-
(2002)
Blood
, vol.100
, pp. 854-861
-
-
Basu, S.1
Hodgson, G.2
Katz, M.3
Dunn, A.R.4
-
15
-
-
0031974729
-
Effects of granulocyte- macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers
-
Dale DC, Liles WC, Llewellyn C, Price TH: Effects of granulocyte- macrophage colony-stimulating factor (GM-CSF) on neutrophil kinetics and function in normal human volunteers. Am J Hematol 1998, 57:7-15
-
(1998)
Am J Hematol
, vol.57
, pp. 7-15
-
-
Dale, D.C.1
Liles, W.C.2
Llewellyn, C.3
Price, T.H.4
-
16
-
-
34147111883
-
Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection
-
Gregory AD, Hogue LA, Ferkol TW, Link DC: Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection. Blood 2007, 109:3235-3243
-
(2007)
Blood
, vol.109
, pp. 3235-3243
-
-
Gregory, A.D.1
Hogue, L.A.2
Ferkol, T.W.3
Link, D.C.4
-
17
-
-
0036800086
-
G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood
-
Semerad CL, Liu F, Gregory AD, Stumpf K, Link DC: G-CSF is an essential regulator of neutrophil trafficking from the bone marrow to the blood. Immunity 2002, 17:413-423
-
(2002)
Immunity
, vol.17
, pp. 413-423
-
-
Semerad, C.L.1
Liu, F.2
Gregory, A.D.3
Stumpf, K.4
Link, D.C.5
-
18
-
-
0035761425
-
Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice
-
Forlow SB, Schurr JR, Kolls JK, Bagby GJ, Schwarzenberger PO, Ley K: Increased granulopoiesis through interleukin-17 and granulocyte colony-stimulating factor in leukocyte adhesion molecule-deficient mice. Blood 2001, 98:3309-3314
-
(2001)
Blood
, vol.98
, pp. 3309-3314
-
-
Forlow, S.B.1
Schurr, J.R.2
Kolls, J.K.3
Bagby, G.J.4
Schwarzenberger, P.O.5
Ley, K.6
-
19
-
-
15244344110
-
Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
-
Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K: Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 2005, 22:285-294
-
(2005)
Immunity
, vol.22
, pp. 285-294
-
-
Stark, M.A.1
Huo, Y.2
Burcin, T.L.3
Morris, M.A.4
Olson, T.S.5
Ley, K.6
-
20
-
-
5644277476
-
Interleukin-17 family members and inflammation
-
Kolls JK, Linden A: Interleukin-17 family members and inflammation. Immunity 2004, 21:467-476
-
(2004)
Immunity
, vol.21
, pp. 467-476
-
-
Kolls, J.K.1
Linden, A.2
-
21
-
-
0033838716
-
Regulation of cell function by Rho family GTPases
-
Bokoch GM: Regulation of cell function by Rho family GTPases. Immunol Res 2000, 21:139-148
-
(2000)
Immunol Res
, vol.21
, pp. 139-148
-
-
Bokoch, G.M.1
-
22
-
-
0024425981
-
Rac, a novel ras-related family of proteins that are botulinum toxin substrates
-
Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R: Rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem 1989, 264:16378-16382
-
(1989)
J Biol Chem
, vol.264
, pp. 16378-16382
-
-
Didsbury, J.1
Weber, R.F.2
Bokoch, G.M.3
Evans, T.4
Snyderman, R.5
-
23
-
-
0035437127
-
Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets
-
Traver D, Miyamoto T, Christensen J, Iwasaki-Arai J, Akashi K, Weissman IL: Fetal liver myelopoiesis occurs through distinct, prospectively isolatable progenitor subsets. Blood 2001, 98:627-635
-
(2001)
Blood
, vol.98
, pp. 627-635
-
-
Traver, D.1
Miyamoto, T.2
Christensen, J.3
Iwasaki-Arai, J.4
Akashi, K.5
Weissman, I.L.6
-
24
-
-
0029971183
-
Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice
-
Bullard DC, Kunkel EJ, Kubo H, Hicks MJ, Lorenzo I, Doyle NA, Doerschuk CM, Ley K, Beaudet AL: Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J Exp Med 1996, 183:2329-2336
-
(1996)
J Exp Med
, vol.183
, pp. 2329-2336
-
-
Bullard, D.C.1
Kunkel, E.J.2
Kubo, H.3
Hicks, M.J.4
Lorenzo, I.5
Doyle, N.A.6
Doerschuk, C.M.7
Ley, K.8
Beaudet, A.L.9
-
25
-
-
0035989343
-
Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses
-
Croker BA, Handman E, Hayball JD, Baldwin TM, Voigt V, Cluse LA, Yang FC, Williams DA, Roberts AW: Rac2-deficient mice display perturbed T-cell distribution and chemotaxis, but only minor abnormalities in T(H)1 responses. Immunol Cell Biol 2002, 80:231-240
-
(2002)
Immunol Cell Biol
, vol.80
, pp. 231-240
-
-
Croker, B.A.1
Handman, E.2
Hayball, J.D.3
Baldwin, T.M.4
Voigt, V.5
Cluse, L.A.6
Yang, F.C.7
Williams, D.A.8
Roberts, A.W.9
-
26
-
-
0034705628
-
Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation
-
Li B, Yu H, Zheng W, Voll R, Na S, Roberts AW, Williams DA, Davis RJ, Ghosh S, Flavell RA: Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science 2000, 288:2219-2222
-
(2000)
Science
, vol.288
, pp. 2219-2222
-
-
Li, B.1
Yu, H.2
Zheng, W.3
Voll, R.4
Na, S.5
Roberts, A.W.6
Williams, D.A.7
Davis, R.J.8
Ghosh, S.9
Flavell, R.A.10
-
27
-
-
33847064631
-
Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells: A role for Rac2 in VSMC activation
-
Tian Y, Autieri MV: Cytokine expression and AIF-1-mediated activation of Rac2 in vascular smooth muscle cells: a role for Rac2 in VSMC activation. Am J Physiol 2007, 292:C841-C849
-
(2007)
Am J Physiol
, vol.292
-
-
Tian, Y.1
Autieri, M.V.2
-
28
-
-
0035109569
-
Mesenchymal stem cells: Heading into the clinic
-
Koc ON, Lazarus HM: Mesenchymal stem cells: heading into the clinic. Bone Marrow Transplant 2001, 27:235-239
-
(2001)
Bone Marrow Transplant
, vol.27
, pp. 235-239
-
-
Koc, O.N.1
Lazarus, H.M.2
-
29
-
-
1542344531
-
Rac1 and Rac2 GTPases in haematopoiesis
-
Weston VJ, Stankovic T: Rac1 and Rac2 GTPases in haematopoiesis. Bioessays 2004, 26:221-224
-
(2004)
Bioessays
, vol.26
, pp. 221-224
-
-
Weston, V.J.1
Stankovic, T.2
-
30
-
-
15544385625
-
Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure
-
Jansen M, Yang FC, Cancelas JA, Bailey JR, Williams DA: Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure. Stem Cells 2005, 23:335-346
-
(2005)
Stem Cells
, vol.23
, pp. 335-346
-
-
Jansen, M.1
Yang, F.C.2
Cancelas, J.A.3
Bailey, J.R.4
Williams, D.A.5
-
31
-
-
23844542698
-
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
-
Cancelas JA, Lee AW, Prabhakar R, Stringer KF, Zheng Y, Williams DA: Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med 2005, 11:886-891
-
(2005)
Nat Med
, vol.11
, pp. 886-891
-
-
Cancelas, J.A.1
Lee, A.W.2
Prabhakar, R.3
Stringer, K.F.4
Zheng, Y.5
Williams, D.A.6
-
32
-
-
20144387139
-
Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways
-
Carstanjen D, Yamauchi A, Koornneef A, Zang H, Filippi MD, Harris C, Towe J, Atkinson S, Zheng Y, Dinauer MC, Williams DA: Rac2 regulates neutrophil chemotaxis, superoxide production, and myeloid colony formation through multiple distinct effector pathways. J Immunol 2005, 174:4613-4620
-
(2005)
J Immunol
, vol.174
, pp. 4613-4620
-
-
Carstanjen, D.1
Yamauchi, A.2
Koornneef, A.3
Zang, H.4
Filippi, M.D.5
Harris, C.6
Towe, J.7
Atkinson, S.8
Zheng, Y.9
Dinauer, M.C.10
Williams, D.A.11
-
33
-
-
0142116231
-
Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling
-
Walmsley MJ, Ooi SK, Reynolds LF, Smith SH, Ruf S, Mathiot A, Vanes L, Williams DA, Cancro MP, Tybulewicz VL: Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling. Science 2003, 302:459-462
-
(2003)
Science
, vol.302
, pp. 459-462
-
-
Walmsley, M.J.1
Ooi, S.K.2
Reynolds, L.F.3
Smith, S.H.4
Ruf, S.5
Mathiot, A.6
Vanes, L.7
Williams, D.A.8
Cancro, M.P.9
Tybulewicz, V.L.10
-
34
-
-
0036533662
-
The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes
-
Croker BA, Tarlinton DM, Cluse LA, Tuxen AJ, Light A, Yang FC, Williams DA, Roberts AW: The Rac2 guanosine triphosphatase regulates B lymphocyte antigen receptor responses and chemotaxis and is required for establishment of B-1a and marginal zone B lymphocytes. J Immunol 2002, 168:3376-3386
-
(2002)
J Immunol
, vol.168
, pp. 3376-3386
-
-
Croker, B.A.1
Tarlinton, D.M.2
Cluse, L.A.3
Tuxen, A.J.4
Light, A.5
Yang, F.C.6
Williams, D.A.7
Roberts, A.W.8
-
35
-
-
0035477599
-
Deficiency of small GTPase Rac2 affects T cell activation
-
Yu H, Leitenberg D, Li B, Flavell RA: Deficiency of small GTPase Rac2 affects T cell activation. J Exp Med 2001, 194:915-926
-
(2001)
J Exp Med
, vol.194
, pp. 915-926
-
-
Yu, H.1
Leitenberg, D.2
Li, B.3
Flavell, R.A.4
-
36
-
-
0038189486
-
Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions
-
Glogauer M, Marchal CC, Zhu F, Worku A, Clausen BE, Foerster I, Marks P, Downey GP, Dinauer M, Kwiatkowski DJ: Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions. J Immunol 2003, 170:5652-5657
-
(2003)
J Immunol
, vol.170
, pp. 5652-5657
-
-
Glogauer, M.1
Marchal, C.C.2
Zhu, F.3
Worku, A.4
Clausen, B.E.5
Foerster, I.6
Marks, P.7
Downey, G.P.8
Dinauer, M.9
Kwiatkowski, D.J.10
-
37
-
-
12544259676
-
Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain
-
Yamauchi A, Marchal CC, Molitoris J, Pech N, Knaus U, Towe J, Atkinson SJ, Dinauer MC: Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain. J Biol Chem 2005, 280:953-964
-
(2005)
J Biol Chem
, vol.280
, pp. 953-964
-
-
Yamauchi, A.1
Marchal, C.C.2
Molitoris, J.3
Pech, N.4
Knaus, U.5
Towe, J.6
Atkinson, S.J.7
Dinauer, M.C.8
|