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Phlebotomine sand flies and Leishmania parasites: friends or foes?
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Kamhawi S. Phlebotomine sand flies and Leishmania parasites: friends or foes?. Trends Parasitol 22 (2006) 439-445
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Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies
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Bates P.A. Transmission of Leishmania metacyclic promastigotes by phlebotomine sand flies. Int J Parasitol 37 (2007) 1097-1106
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Bates, P.A.1
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Flagellar motility is required for the viability of the bloodstream trypanosome
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Broadhead R., Dawe H.R., Farr H., Griffiths S., Hart S.R., Portman N., Shaw M.K., Ginger M.L., Gaskell S.J., McKean P.G., and Gull K. Flagellar motility is required for the viability of the bloodstream trypanosome. Nature 440 (2006) 224-227
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A novel microtubule-depolymerizing kinesin involved in length control of a eukaryotic flagellum
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This paper describes a motor protein (kinesin) localised to the Leishmania flagellum that regulates flagellar length via microtubule binding and de-polymerising activity.
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Blaineau C., Tessier M., Dubessay P., Tasse L., Crobu L., Pages M., and Bastien P. A novel microtubule-depolymerizing kinesin involved in length control of a eukaryotic flagellum. Curr Biol 17 (2007) 778-782. This paper describes a motor protein (kinesin) localised to the Leishmania flagellum that regulates flagellar length via microtubule binding and de-polymerising activity.
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Curr Biol
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Blaineau, C.1
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Intraflagellar transport complex in Leishmania spp. In silico genome-wide screening and annotation of gene function
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Gouveia J.J.S., Vasconcelos E.J.R., Pacheco A.C.L., Araujo-Filho R., Maia A.R.S., Kamimura M.T., Costa M.P., Viana D.A., Costa R.B., Maggioni R., and Oliveira D.M. Intraflagellar transport complex in Leishmania spp. In silico genome-wide screening and annotation of gene function. Genet Mol Res 6 (2007) 766-798
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Gouveia, J.J.S.1
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39049170214
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Involvement of a Leishmania thymidine kinase in flagellum formation, promastigote shape and growth as well as virulence
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Intriguing findings that show a role for Leishmania thymidine kinase in regulating flagellar length, possibly by a novel type of signalling pathway.
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Thiel M., Harder S., Wiese M., Kroemer M., and Bruchaus I. Involvement of a Leishmania thymidine kinase in flagellum formation, promastigote shape and growth as well as virulence. Mol Biochem Parasitol 158 (2008) 152-162. Intriguing findings that show a role for Leishmania thymidine kinase in regulating flagellar length, possibly by a novel type of signalling pathway.
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Mol Biochem Parasitol
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Thiel, M.1
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Sahin, A.1
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Aquaglyceroporins form membrane channels for low molecular weight solutes and water. Leishmania aquaglyceroporin localises to the flagellum and is involved in osmotaxis by promastigotes.
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Figarella K., Uzcategui N.L., Zhou Y., LeFurgey A., Ouellette M., Bhattacharjee H., and Mukhopadhyay R. Biochemical characterization of Leishmania major aquaglyceroporin LmAQP1: possible role in volume regulation and osmotaxis. Mol Microbiol 65 (2007) 1006-1017. Aquaglyceroporins form membrane channels for low molecular weight solutes and water. Leishmania aquaglyceroporin localises to the flagellum and is involved in osmotaxis by promastigotes.
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Figarella, K.1
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Bhattacharjee, H.6
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Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications
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Dobson D.E., Scholtes L.E., Myler P.J., Turco S.J., and Beverley S.M. Genomic organization and expression of the expanded SCG/L/R gene family of Leishmania major: internal clusters and telomeric localization of SCGs mediating species-specific LPG modifications. Mol Biochem Parasitol 146 (2006) 231-241
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A lipophosphoglycan-independent development of Leishmania in permissive sand flies
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First paper to indicate that lipophosphoglycan is not always required for attachment and survival of Leishmania promastigotes in sand flies, challenging the existing paradigm.
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Myskova J., Svobodova M., Beverley S.M., and Volf P. A lipophosphoglycan-independent development of Leishmania in permissive sand flies. Microbes Infect 9 (2007) 317-324. First paper to indicate that lipophosphoglycan is not always required for attachment and survival of Leishmania promastigotes in sand flies, challenging the existing paradigm.
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Myskova, J.1
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Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy
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Convincing analysis supporting the hypothesis that visceral leishmaniasis is an introduced disease in South America that has been spread by the permissive sand fly vector Lutzomyia longipalpis.
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Lukes J., Mauricio I.L., Schonian G., Dujardin J.C., Soteriadou K., Dedet J.P., Kuhls K., Quispe Tintaya K.W., Jirku M., Chocholova E., et al. Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy. Proc Natl Acad Sci U S A 104 (2007) 9375-9380. Convincing analysis supporting the hypothesis that visceral leishmaniasis is an introduced disease in South America that has been spread by the permissive sand fly vector Lutzomyia longipalpis.
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Analysis of the autophagosomal pathway in Leishmania that revealed an important role in cellular remodelling and survival under starvation conditions during the differentiation of infective forms.
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Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania
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Discovery of a novel role for sphingolipids in the biosynthesis of ethanolamine and the importance of this pathway in the differentiation of infective forms.
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First direct evidence that Leishmania secretory chitinase is of survival value in the sand fly vector, both in escaping the bloodmeal and in transmission by sand fly bite.
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Demonstration that infection with Leishmania can alter the feeding behaviour of the sand fly vector in tune with parasite development to maximise transmission.
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Rogers M.E., and Bates P.A. Leishmania manipulation of sand fly feeding behaviour results in enhanced transmission. PLoS Pathogens 3 (2007) e91. Demonstration that infection with Leishmania can alter the feeding behaviour of the sand fly vector in tune with parasite development to maximise transmission.
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Interesting proposition that altruistic apoptotic promastigotes can aid the transmission of viable infective forms by providing an 'eat me' signal to promote silent phagocytosis.
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Van Zandbergen G., Bollinger A., Wenzel A., Kamhawi S., Voll R., Klinger M., Muller A., Holscher C., Herrmann M., Sacks D., et al. Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum. Proc Natl Acad Sci U S A 103 (2006) 13837-13842. Interesting proposition that altruistic apoptotic promastigotes can aid the transmission of viable infective forms by providing an 'eat me' signal to promote silent phagocytosis.
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