SDF-1α is a potent inducer of HIV-1-specific CD8+ T-cell chemotaxis, but migration of CD8+ T cells is impaired at high viral loads

AIDS Research and Human Retroviruses

Volumn 24, Issue 7, 2008, Pages 977-985

  Meditz, Amie L ^a   Schlichtemeier, Rick ^a   Folkvord, Joy M ^a   Givens, Monique ^a,b   Lesh, Kevin C ^a,c   Ray, M G ^a   McCarter, Martin D ^a   Connick, Elizabeth ^a,d  

^a UNIVERSITY OF COLORADO   (United States)

^b Research and Development   (United States)

^c Lynn Institute of the Rockies   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR4; FRACTALKINE; STROMAL CELL DERIVED FACTOR 1ALPHA; VIRUS RNA; STROMAL CELL DERIVED FACTOR 1;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL MIGRATION; CELL SPECIFICITY; CHEMOTAXIS; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOSE RESPONSE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN TISSUE; IN VITRO STUDY; INGUINAL LYMPH NODE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS LOAD; VIRUS REPLICATION; DRUG EFFECT; GENETICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; ISOLATION AND PURIFICATION; LYMPH NODE; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; NEUTROPHIL CHEMOTAXIS; VIROLOGY;

ADULT; CHEMOKINE CX3CL1; CHEMOKINE CXCL12; CHEMOTAXIS, LEUKOCYTE; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; LYMPH NODES; MALE; MIDDLE AGED; T-LYMPHOCYTES, CYTOTOXIC; VIRAL LOAD;

EID: 48749106623     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2007.0259     Document Type: Article

References (43)

1. Koup RA, Safrit JT Cao Y, Andrews CA, McLeod G, Borkowsky W, et al.: Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 1994;68:4650-4655.
2. Jin X, Bauer DE, Tuttleton SE, Lewin S, Gettie A, Blanchard J, et al.: Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 1999;189:991-998.
3. Goepfert PA, Bansal A, Edwards BH, Ritter GD Jr., Tellez I, McPherson SA, et al.: A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon. J Virol 2000;74:10249-10255.
4. Appay V, Nixon DF, Donahoe SM, Gillespie GM, Dong T, King A, et al.: HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med 2000;192:63-75.
5. Kostense S, Ogg GS, Manting EH, Gillespie G, Joling J, Vandenberghe K, et al.: High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function. Eur J Immunol 2001;31:677-686.
6. Shankar P, Russo M, Harnisch B, Patterson M, Skolnik P, and Lieberman J: Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection. Blood 2000;96:3094-3101.
7. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, et al.: HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 1993;362:355-358.
8. Embretson J, Zupancic M, Ribas JL, Burke A, Racz P, Tenner-Racz K, et al.: Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 1993;362:359-362.
9. Tenner-Racz K, Racz P, Bofill M, Schulz-Meyer A, Dietrich M, Kern P, et al.: HTLV-III/LAV viral antigens in lymph nodes of homosexual men with persistent generalized lymphadenopathy and AIDS. Am J Pathol 1986;123:9-15.
10. Tedla N, Dwyer J, Truskett P, Taub D, Wakefield D, and Lloyd A: Phenotypic and functional characterization of lymphocytes derived from normal and HIV-1-infected human lymph nodes. Clin Exp Immunol 1999;117:92-99.
11. Stein JV and Nombela-Arrieta C: Chemokine control of lymphocyte trafficking: a general overview. Immunology 2005;116:1-12.
12. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, and Springer TA: A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 1996;184:1101-1109.
13. Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, et al.: The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 1996;382:829-833.
14. Foussat A, Coulomb-L'Hermine A, Gosling J, Krzysiek R, Durand-Gasselin I, Schall T, et al.: Fractalkine receptor expression by T lymphocyte subpopulations and in vivo production of fractalkine in human. Eur J Immunol 2000;30:87-97.
15. Combadiere B, Faure S, Autran B, Debre P, and Combadiere C: The chemokine receptor CX3CR1 controls homing and anti-viral potencies of CD8 effector-memory T lymphocytes in HIV-infected patients. AIDS 2003;17:1279-1290.
16. Combadiere C, Salzwedel K, Smith ED, Tiffany HL, Berger EA, and Murphy PM: Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1. J Biol Chem 1998;273:23799-23804.
17. Bleul CC, Wu L, Hoxie JA, Springer TA, and Mackay CR: The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci U S A 1997;94:1925-1930.
18. Kobayashi, N, Takata H, Yokota S, and Takiguchi M: Down-regulation of CXCR4 expression on human CD8+ T cells during peripheral differentiation. Eur J Immunol 2004;34:3370-3378.
19. Folkvord JM, Anderson DM, Arya J, MaWhinney S, and Connick E: Microanatomic relationships between CD8+ cells and HIV-1-producing cells in human lymphoid tissue in vivo. J Acquir Immune Defic Syndr 2003;32:469-476.
20. Storie I, Sawle A, Goodfellow K, Whitby L, Granger V, Reilly JT, et al.: Flow rate calibration I: a novel approach for performing absolute cell counts. Cytometry B Clin Cytom 2003;55:1-7.
21. Storie I, Sawle A, Whitby L, Goodfellow K, Granger V, Reilly JT, et al.: Flow rate calibration II: a clinical evaluation study using PanLeucoGating as a single-platform protocol. Cytometry B Clin Cytom 2003;55:8-13.
22. Folkvord JM, Armon C, and Connick E: Lymphoid follicles are sites of heightened human immunodeficiency virus type 1 (HIV-1) replication and reduced antiretroviral effector mechanisms. AIDS Res Hum Retroviruses 2005;21:363-370.
23. Connick, E, Mattila T, Folkvord JM, Schlichtemeier R, Meditz AL, Ray MG, et al.: CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue. J Immunol 2007;178:6975-6983.
24. Berhanu D, Mortari F, De Rosa SC, and Roederer M: Optimized lymphocyte isolation methods for analysis of chemokine receptor expression. J Immunol Methods 2003;279:199-207.
25. Ostrowski MA, Justement SJ, Catanzaro A, Hallahan CA, Ehler LA, Mizell SB, et al.: Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals. J Immunol 1998;161:3195-3201.
26. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, et al.: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 1996;382:833-835.
27. Yang OO, Ferbas JJ, Hausner MA, Hultin LE, Hultin PM, McFadden D, et al.: Effects of HIV-1 infection on lymphocyte phenotypes in blood versus lymph nodes. J Acquir Immune Defic Syndr 2005;39:507-518.
28. Signoret N, Oldridge J, Pelchen-Matthews A, Klasse PJ, Tran T, Brass LF, et al.: Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4. J Cell Biol 1997;139:651-664.
29. Ohashi T, Arai M, Kato H, Kubo M, Fujii M, Yamamoto N, et al.: High SDF-1 expression in HIV-1 carriers does not correlate with CD8 T-cell-mediated suppression of viral replication. Virology 1998;244:467-472.
30. Venzke S, Michel N, Allespach I, Fackler OT, and Keppler OT: Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection. J Virol 2006;80:11141-11152.
31. Poznansky MC, Olszak IT, Foxall R, Evans RH, Luster AD, and Scadden DT: Active movement of T cells away from a chemokine. Nat Med 2000;6:543-548.
32. Busillo JM and Benovic JL: Regulation of CXCR4 signaling. Biochim Biophys Acta 2007;1768:952-963.
33. Estes JD, Thacker TC, Hampton DL, Kell SA, Keele BF, Palenske EA, et al.: Follicular dendritic cell regulation of CXCR4-mediated germinal center CD4 T cell migration. J Immunol 2004;173:6169-6178.
34. Peacock JW and Jirik FR: TCR activation inhibits chemotaxis toward stromal cell-derived factor-1: evidence for reciprocal regulation between CXCR4 and the TCR. J Immunol 1999;162:215-223.
35. Choe EY, Schoenberger ES, Groopman JE, and Park IW: HIV Nef inhibits T cell migration. J Biol Chem 2002;277:46079-46084.
36. Garin A, Tarantino N, Faure S, Daoudi M, Lecureuil C, Bourdais A, et al.: Two novel fully functional isoforms of CX3CR1 are potent HIV coreceptors. J Immunol 2003;171:5305-5312.
37. Faure S, Meyer L, Costagliola D, Vaneensberghe C, Genin E, Autran B, et al.: Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1. Science 2000;287:2274-2277.
38. Singh KK, Hughes MD, Chen J, and Spector SA: Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load. J Infect Dis 2005;191:1971-1980.
39. McDermott DH, Colla JS, Kleeberger CA, Plankey M, Rosenberg PS, Smith ED, et al.: Genetic polymorphism in CX3CR1 and risk of HIV disease. Science 2000;290:2031.
40. Nishimura M, Umehara H, Nakayama T, Yoneda O, Hieshima K, Kakizaki M, et al.: Dual functions of fractalkine/CX3C ligand 1 in trafficking of perforin+/granzyme B+ cytotoxic effector lymphocytes that are defined by CX3CR1 expression. J Immunol 2002;168:6173-6180.
41. Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, et al.: Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 1997;91:521-530.
42. Brask S, Hager H, Pallesen G, Porwit A, Biberfeld P, and Gerstoft J: Quantification of CD8-positive lymphocytes in lymph node follicles from HIV-infected male homosexuals and controls. Acta Pathol Microbiol Immunol Scand [A] 1987;95:155-157.
43. Wood GS, Burns BF, Dorfman RF, and Warnke RA: In situ quantitation of lymph node helper, suppressor, and cytotoxic T cell subsets in AIDS. Blood 1986;67:596-603.