메뉴 건너뛰기




Volumn 78, Issue 1, 2008, Pages 3-8

Molecular mechanism of apoptosis induction by resveratrol, a natural cancer chemopreventive agent

Author keywords

Apoptosis; Extrinsic pathway; Intrinsic pathway; Resveratrol

Indexed keywords

CASPASE 9; CERAMIDE; DEATH RECEPTOR; FAS LIGAND; INHIBITOR OF APOPTOSIS PROTEIN; PACLITAXEL; PROTEIN BAK; PROTEIN BAX; RESVERATROL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SURVIVIN;

EID: 48749106316     PISSN: 03009831     EISSN: None     Source Type: Journal    
DOI: 10.1024/0300-9831.78.1.3     Document Type: Article
Times cited : (23)

References (48)
  • 1
    • 24744438412 scopus 로고    scopus 로고
    • Determination of trans-resveratrol in China Great Wall "Fazenda" red wine by use of micellar electrokinetic chromatography
    • Fan, E., Zhang, K., Yao, C. et al. (2005) Determination of trans-resveratrol in China Great Wall "Fazenda" red wine by use of micellar electrokinetic chromatography. Chro-matographia 62, 289.
    • (2005) Chro-matographia , vol.62 , pp. 289
    • Fan, E.1    Zhang, K.2    Yao, C.3
  • 2
    • 0031561513 scopus 로고    scopus 로고
    • Cancer chemo-preventive activity of resveratrol, a natural product derived from grapes
    • Jang, M., Cai, L., Udeani, G.O. et al. (1997) Cancer chemo-preventive activity of resveratrol, a natural product derived from grapes. Science 275, 218.
    • (1997) Science , vol.275 , pp. 218
    • Jang, M.1    Cai, L.2    Udeani, G.O.3
  • 3
    • 0035866404 scopus 로고    scopus 로고
    • Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
    • She, Q.B., Bode, A.M., Ma, W.Y. et al. (2001) Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res. 61, 1604.
    • (2001) Cancer Res , vol.61 , pp. 1604
    • She, Q.B.1    Bode, A.M.2    Ma, W.Y.3
  • 4
    • 7044240646 scopus 로고    scopus 로고
    • Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells
    • Fulda, S., Jeremias, I. and Debatin, K.M. (2004) Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells. Oncogene 23, 7611.
    • (2004) Oncogene , vol.23 , pp. 7611
    • Fulda, S.1    Jeremias, I.2    Debatin, K.M.3
  • 5
    • 48749095535 scopus 로고    scopus 로고
    • Beneficial effects of resveratrol on atherosclerosis
    • in submission
    • Fan, E., Zhang, L., Jiang, S. et al. (2006) Beneficial effects of resveratrol on atherosclerosis. Natural Product R&D (in submission)
    • (2006) Natural Product R&D
    • Fan, E.1    Zhang, L.2    Jiang, S.3
  • 6
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz, K.T., Bitterman, K.J., Cohen, H.Y. et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191.
    • (2003) Nature , vol.425 , pp. 191
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 8
    • 1542322900 scopus 로고    scopus 로고
    • Why target apoptosis in cancer treatment?
    • Kasibhatla, S. and Tseng, B. (2003) Why target apoptosis in cancer treatment? Mol. Cancer Ther. 2, 573.
    • (2003) Mol. Cancer Ther , vol.2 , pp. 573
    • Kasibhatla, S.1    Tseng, B.2
  • 9
    • 0037169358 scopus 로고    scopus 로고
    • Apoptosis: A link between cancer genetics and chemotherapy
    • Johnstone, R.W., Ruefli, A. A. and Lowe, S.W. (2002) Apoptosis: a link between cancer genetics and chemotherapy. Cell 108, 153.
    • (2002) Cell , vol.108 , pp. 153
    • Johnstone, R.W.1    Ruefli, A.A.2    Lowe, S.W.3
  • 10
    • 0033400809 scopus 로고    scopus 로고
    • Apoptosis and cancer drug targeting
    • Sellers, W.R. and Fisher, D.E. (1999) Apoptosis and cancer drug targeting. J. Clin. Invest. 104, 1655.
    • (1999) J. Clin. Invest , vol.104 , pp. 1655
    • Sellers, W.R.1    Fisher, D.E.2
  • 11
    • 0042318707 scopus 로고    scopus 로고
    • Apoptosis-an introduction
    • Lawen, A. (2003) Apoptosis-an introduction. Bioessays 25, 888.
    • (2003) Bioessays , vol.25 , pp. 888
    • Lawen, A.1
  • 12
    • 3042736842 scopus 로고    scopus 로고
    • Implications of apoptosis regulators in tumorigenesis
    • Malaguarnera, L. (2004) Implications of apoptosis regulators in tumorigenesis. Cancer Metastasis Rev. 23, 367.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 367
    • Malaguarnera, L.1
  • 13
    • 2442460088 scopus 로고    scopus 로고
    • Role of mitochondrial membrane permeabilization in apoptosis and cancer
    • Henry-Mowatt J., Dive, C., Martinou, J.C. et al. (2004) Role of mitochondrial membrane permeabilization in apoptosis and cancer. Oncogene 23, 2850.
    • (2004) Oncogene , vol.23 , pp. 2850
    • Henry-Mowatt, J.1    Dive, C.2    Martinou, J.C.3
  • 14
    • 0242301742 scopus 로고    scopus 로고
    • Wine and resveratrol: Mechanisms of cancer prevention?
    • Bianchini, F. and Vainio, H. (2003) Wine and resveratrol: mechanisms of cancer prevention? Eur. J. Cancer Prev. 12, 417.
    • (2003) Eur. J. Cancer Prev , vol.12 , pp. 417
    • Bianchini, F.1    Vainio, H.2
  • 15
    • 11144237662 scopus 로고    scopus 로고
    • An-tiangiogenic properties of natural polyphenols from red wine and green tea
    • Oak M.H., EI Bedoui, J. and Schini-Kerth, V.B. (2005) An-tiangiogenic properties of natural polyphenols from red wine and green tea. J. Nutr. Biochem. 16, 1.
    • (2005) J. Nutr. Biochem , vol.16 , pp. 1
    • Oak, M.H.1    EI Bedoui, J.2    Schini-Kerth, V.B.3
  • 16
    • 0345566753 scopus 로고    scopus 로고
    • Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells
    • Clement, M.V., Hirpara, J.L., Chawdhury, S.H. et al. (1998) Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 92, 996.
    • (1998) Blood , vol.92 , pp. 996
    • Clement, M.V.1    Hirpara, J.L.2    Chawdhury, S.H.3
  • 17
    • 0033828138 scopus 로고    scopus 로고
    • Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells
    • Bernhard, D., Tinhofer, I., Tonko, M. et al. (2000) Resveratrol causes arrest in the S-phase prior to Fas-independent apoptosis in CEM-C7H2 acute leukemia cells. Cell Death Differ. 7, 834.
    • (2000) Cell Death Differ , vol.7 , pp. 834
    • Bernhard, D.1    Tinhofer, I.2    Tonko, M.3
  • 18
    • 0034038578 scopus 로고    scopus 로고
    • Resveratrol induces Fas signalling-independent apoptosis in THP-1 human monocytic leukaemia cells
    • Tsan, M.F., White, J.E., Maheshwari, J.G. et al. (2000) Resveratrol induces Fas signalling-independent apoptosis in THP-1 human monocytic leukaemia cells. Br. J. Haematol. 109, 405.
    • (2000) Br. J. Haematol , vol.109 , pp. 405
    • Tsan, M.F.1    White, J.E.2    Maheshwari, J.G.3
  • 19
    • 0035874886 scopus 로고    scopus 로고
    • Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells
    • Dorrie, J., Gerauer, H., Wachter, Y. et al. (2001) Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 61, 4731.
    • (2001) Cancer Res , vol.61 , pp. 4731
    • Dorrie, J.1    Gerauer, H.2    Wachter, Y.3
  • 20
    • 13444302910 scopus 로고    scopus 로고
    • Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASKl/JNK-dependent signaling pathway in human leukemia HL-60 cells
    • Su, J.L., Lin, M.T., Hong, C.C. et al. (2005) Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASKl/JNK-dependent signaling pathway in human leukemia HL-60 cells. Carcinogenesis 26, 1.
    • (2005) Carcinogenesis , vol.26 , pp. 1
    • Su, J.L.1    Lin, M.T.2    Hong, C.C.3
  • 21
    • 1642576201 scopus 로고    scopus 로고
    • Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol
    • Fulda, S. and Debatin, K.M. (2004) Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res. 64, 337.
    • (2004) Cancer Res , vol.64 , pp. 337
    • Fulda, S.1    Debatin, K.M.2
  • 22
    • 16744364517 scopus 로고    scopus 로고
    • Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells
    • Delmas, D., Rebe, C., Lacour, S. et al. (2003) Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J. Biol. Chem. 278, 41482.
    • (2003) J. Biol. Chem , vol.278 , pp. 41482
    • Delmas, D.1    Rebe, C.2    Lacour, S.3
  • 23
    • 13844280434 scopus 로고    scopus 로고
    • FADD-depen-dent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene
    • Wang, Y., Wang, B., Cheng, J. et al. (2005) FADD-depen-dent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene. Biochem. Pharmacol. 69, 249.
    • (2005) Biochem. Pharmacol , vol.69 , pp. 249
    • Wang, Y.1    Wang, B.2    Cheng, J.3
  • 24
    • 10644246821 scopus 로고    scopus 로고
    • Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells
    • Delmas, D., Rebe, C., Micheau, O. et al. (2004) Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells. Oncogene 23, 8979.
    • (2004) Oncogene , vol.23 , pp. 8979
    • Delmas, D.1    Rebe, C.2    Micheau, O.3
  • 25
    • 14844312113 scopus 로고    scopus 로고
    • Resveratrol-mediated sensitisation to TRAIL-induced apoptosis depends on death receptor and mitochondrial signaling
    • Fulda, S. and Debatin, K.M. (2005) Resveratrol-mediated sensitisation to TRAIL-induced apoptosis depends on death receptor and mitochondrial signaling. Eur. J. Cancer 41, 786.
    • (2005) Eur. J. Cancer , vol.41 , pp. 786
    • Fulda, S.1    Debatin, K.M.2
  • 26
    • 18044393290 scopus 로고    scopus 로고
    • Resveratrol-in-duced apoptotic death in human U251 glioma cells
    • Jiang, H., Zhang, L., Kuo, J. et al. (2005) Resveratrol-in-duced apoptotic death in human U251 glioma cells. Mol. Cancer Ther. 4, 554.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 554
    • Jiang, H.1    Zhang, L.2    Kuo, J.3
  • 27
    • 4444274529 scopus 로고    scopus 로고
    • Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis
    • Jazirehi, A.R. and Bonavida, B. (2004) Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol. Cancer Ther. 3, 71.
    • (2004) Mol. Cancer Ther , vol.3 , pp. 71
    • Jazirehi, A.R.1    Bonavida, B.2
  • 28
    • 18044393290 scopus 로고    scopus 로고
    • Resveratrol-induced apoptotic death in human U251 glioma cells
    • Gautam, S.C.,Groc, L., Rodriguez, A.I. et al. (2005) Resveratrol-induced apoptotic death in human U251 glioma cells. Mol. Cancer Ther. 4, 554.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 554
    • Gautam, S.C.1    Groc, L.2    Rodriguez, A.I.3
  • 29
    • 21344432372 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis and differentiation in acute promyelocytic leukemia (NB4) cells
    • Wang, F., Liu, H.Y., Fu, Z.D. et al. (2005) Resveratrol induces apoptosis and differentiation in acute promyelocytic leukemia (NB4) cells. J. Asian Nat. Prod. Res. 7, 633.
    • (2005) J. Asian Nat. Prod. Res , vol.7 , pp. 633
    • Wang, F.1    Liu, H.Y.2    Fu, Z.D.3
  • 30
    • 15744383234 scopus 로고    scopus 로고
    • Vaticanol C-induced cell death is associated with inhibition of pro-survival signaling in HL60 human leukemia cell line
    • Ohguchi, K., Akao,Y., Matsumoto, K. et al. (2005) Vaticanol C-induced cell death is associated with inhibition of pro-survival signaling in HL60 human leukemia cell line. Biosci. Biotechnol. Biochem. 69, 353.
    • (2005) Biosci. Biotechnol. Biochem , vol.69 , pp. 353
    • Ohguchi, K.1    Akao, Y.2    Matsumoto, K.3
  • 31
    • 11144348684 scopus 로고    scopus 로고
    • Pharmacological preconditioning with resveratrol: Role of CREB-de-pendent Bcl-2 signaling via adenosine A3 receptor activation
    • Das, S., Cordis, G.A., Maulik, N. et al. (2005) Pharmacological preconditioning with resveratrol: role of CREB-de-pendent Bcl-2 signaling via adenosine A3 receptor activation. Am. J. Physiol. Heart Circ. Physiol. 288, H328.
    • (2005) Am. J. Physiol. Heart Circ. Physiol , vol.288
    • Das, S.1    Cordis, G.A.2    Maulik, N.3
  • 32
    • 3242815537 scopus 로고    scopus 로고
    • Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells
    • Kim, Y.A., Choi, B.T., Lee, Y.T. et al. (2004) Resveratrol inhibits cell proliferation and induces apoptosis of human breast carcinoma MCF-7 cells. Oncol. Rep. 11, 441.
    • (2004) Oncol. Rep , vol.11 , pp. 441
    • Kim, Y.A.1    Choi, B.T.2    Lee, Y.T.3
  • 33
    • 32144436448 scopus 로고    scopus 로고
    • Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways
    • Shimizu, T., Nakazato, T., Xian, M.J. et al. (2006) Resveratrol induces apoptosis of human malignant B cells by activation of caspase-3 and p38 MAP kinase pathways. Biochem. Pharmacol. 71, 742.
    • (2006) Biochem. Pharmacol , vol.71 , pp. 742
    • Shimizu, T.1    Nakazato, T.2    Xian, M.J.3
  • 34
    • 33745808321 scopus 로고    scopus 로고
    • Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore
    • Zunino, S.J. and Storms, D.H. (2006) Resveratrol-induced apoptosis is enhanced in acute lymphoblastic leukemia cells by modulation of the mitochondrial permeability transition pore. Cancer Lett. 240, 123.
    • (2006) Cancer Lett , vol.240 , pp. 123
    • Zunino, S.J.1    Storms, D.H.2
  • 35
    • 1342302810 scopus 로고    scopus 로고
    • Heyneanol A induces apoptosis via cytochrome c release and caspase activation in human leukemic U937 cells [J]
    • Lee, E.O., Kwon, B.M., Song, G.Y. et al. (2004) Heyneanol A induces apoptosis via cytochrome c release and caspase activation in human leukemic U937 cells [J]. Life Sci. 74, 2313.
    • (2004) Life Sci , vol.74 , pp. 2313
    • Lee, E.O.1    Kwon, B.M.2    Song, G.Y.3
  • 36
    • 1642576020 scopus 로고    scopus 로고
    • Antiproliferative effect of resveratrol in human prostate carcinoma cells
    • Kim, YA., Rhee, S.H., Park, K.Y et al. (2003) Antiproliferative effect of resveratrol in human prostate carcinoma cells. J. Med. Food 6, 273.
    • (2003) J. Med. Food , vol.6 , pp. 273
    • Kim, Y.A.1    Rhee, S.H.2    Park, K.Y.3
  • 37
    • 0642364447 scopus 로고    scopus 로고
    • Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling
    • Scarlatti, E., Sala, G., Somenzi, G. et al. (2003) Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J. 17, 2339.
    • (2003) FASEB J , vol.17 , pp. 2339
    • Scarlatti, E.1    Sala, G.2    Somenzi, G.3
  • 38
    • 27444446522 scopus 로고    scopus 로고
    • Synthesis of a Resveratrol Analogue with High Ceramide-Mediat-ed Proapoptotic Activity on Human Breast Cancer Cells
    • Minutolo, F., Sala, G., Bagnacani, A. et al. (2005) Synthesis of a Resveratrol Analogue with High Ceramide-Mediat-ed Proapoptotic Activity on Human Breast Cancer Cells. J. Med. Chem. 48, 6783.
    • (2005) J. Med. Chem , vol.48 , pp. 6783
    • Minutolo, F.1    Sala, G.2    Bagnacani, A.3
  • 39
    • 2342557286 scopus 로고    scopus 로고
    • Resveratrol structure and ceramide-associated growth inhibition in prostate cancer cells
    • Sala, G., Minutolo, F., Macchia, M. et al. (2003) Resveratrol structure and ceramide-associated growth inhibition in prostate cancer cells. Drugs Exp. Clin. Res. 29, 263.
    • (2003) Drugs Exp. Clin. Res , vol.29 , pp. 263
    • Sala, G.1    Minutolo, F.2    Macchia, M.3
  • 40
    • 0038777473 scopus 로고    scopus 로고
    • Resveratrol induces downregulation in survivin expression and apoptosis in HTLV-1-infected cell lines: A prospective agent for adult T cell leukemia chemotherapy
    • Hayashibara, T., Yamada, Y., Nakayama, S. et al. (2002) Resveratrol induces downregulation in survivin expression and apoptosis in HTLV-1-infected cell lines: a prospective agent for adult T cell leukemia chemotherapy. Nutr. Cancer 44, 193.
    • (2002) Nutr. Cancer , vol.44 , pp. 193
    • Hayashibara, T.1    Yamada, Y.2    Nakayama, S.3
  • 41
    • 4644327128 scopus 로고    scopus 로고
    • Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol
    • Fulda, S. and Debatin, K.M. (2004) Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 23, 6702.
    • (2004) Oncogene , vol.23 , pp. 6702
    • Fulda, S.1    Debatin, K.M.2
  • 42
    • 14744268831 scopus 로고    scopus 로고
    • Aziz, M.H., Afaq, E and Ahmad, N. (2005) Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in surviving. Photochem. Pho-tobiol. 81,25.
    • Aziz, M.H., Afaq, E and Ahmad, N. (2005) Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in surviving. Photochem. Pho-tobiol. 81,25.
  • 43
    • 0037157069 scopus 로고    scopus 로고
    • Plant foods and herbal sources of resveratrol
    • Burns, J., Yokota, T., Ashihara, H. et al. (2002) Plant foods and herbal sources of resveratrol. J. Agric. Food Chem. 50, 3337.
    • (2002) J. Agric. Food Chem , vol.50 , pp. 3337
    • Burns, J.1    Yokota, T.2    Ashihara, H.3
  • 44
    • 0037082355 scopus 로고    scopus 로고
    • The "French Paradox" and beyond: Neuroprotective effects of polyphenols
    • Sun, A.Y., Simonyi, A. and Sun, G.Y (2002) The "French Paradox" and beyond: neuroprotective effects of polyphenols. Free Radic. Biol. Med. 32, 314.
    • (2002) Free Radic. Biol. Med , vol.32 , pp. 314
    • Sun, A.Y.1    Simonyi, A.2    Sun, G.Y.3
  • 45
    • 5644283296 scopus 로고    scopus 로고
    • Role of chemopreventive agents in cancer therapy
    • Dorai, T. and Aggarwal, B.B. (2004) Role of chemopreventive agents in cancer therapy. Cancer Lett. 215, 129.
    • (2004) Cancer Lett , vol.215 , pp. 129
    • Dorai, T.1    Aggarwal, B.B.2
  • 46
    • 5144223780 scopus 로고    scopus 로고
    • Molecular basis of chemo-prevention by resveratrol: NF-kappaB and AP-1 as potential targets
    • Kundu, J.K. and Surh, Y.J. (2004) Molecular basis of chemo-prevention by resveratrol: NF-kappaB and AP-1 as potential targets. Mutat. Res. 555, 65.
    • (2004) Mutat. Res , vol.555 , pp. 65
    • Kundu, J.K.1    Surh, Y.J.2
  • 47
    • 0346074656 scopus 로고    scopus 로고
    • Cancer chemo-prevention by resveratrol: In vitro and in vivo studies and the underlying mechanisms
    • Aziz, M.H., Kumar, R. and Ahmad, N. (2003) Cancer chemo-prevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms. Int. J. Oncol. 23, 17.
    • (2003) Int. J. Oncol , vol.23 , pp. 17
    • Aziz, M.H.1    Kumar, R.2    Ahmad, N.3
  • 48
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur, J.A. and Sinclair, D.A. (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5, 493.
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 493
    • Baur, J.A.1    Sinclair, D.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.