Effect of 150-mg vs 300-mg loading doses of clopidogrel on platelet function in Japanese patients undergoing coronary stent placement

Circulation Journal

Volumn 72, Issue 8, 2008, Pages 1282-1284

  Fukushima, Kenichi ^a   Kobayashi, Yoshio ^a   Kitahara, Hideki ^a   Iwata, Yo ^a   Nakayama, Takashi ^a   Kuroda, Nakabumi ^a   Ooyama, Masayuki ^a   Nomura, Fumio ^a   Komuro, Issei ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Antiplatelet therapy; Stent; Stent thrombosis

Indexed keywords

ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITRATE; PROTON PUMP INHIBITOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CORONARY STENT; DRUG DOSE COMPARISON; DRUG EFFECT; FEMALE; HUMAN; HUMAN TISSUE; JAPANESE; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; THROMBOSIS;

ADENOSINE DIPHOSPHATE; AGED; ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; ASIAN CONTINENTAL ANCESTRY GROUP; CORONARY ARTERY DISEASE; CORONARY THROMBOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; JAPAN; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; STENTS; TICLOPIDINE; TIME FACTORS; TREATMENT OUTCOME;

EID: 48749096406     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.72.1282     Document Type: Article

References (12)

1. Gawaz M, Seyfaith M, Müller I, Rüdiger S, Pogatsa-Murray G, Wolf B, et al. Comparison of effects of clopidogrel versus ticlopidine on platelet function in patients undergoing coronary stent placement. Am J Cardiol 2001; 87: 332-336.
2. Müller I, Seyfarth M, RüdigerS, Wolf B, Pogatsa-Murray G, Schömig A, et al. Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement. Heart 2001; 85: 92-93.
3. von Beckerath N, Taubert D, Pogatsa-Murray G, Schomig E, Kastrati A, Schömig A. Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: Results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial. Circulation 2005; 112: 2946-2950.
4. Gurbel PA, Bliden KP, Hayes KM, Yoho JA, Herzog WR, Tantry US. The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting. J Am Coll Cardiol 2005; 45: 1392-1396.
5. Moussa I, Oetgen M, Roubin G, Colombo A, Wang X, Iyer S, et al. Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation. Circulation 1999; 99: 2364-2366.
6. Fukushima K, Kobayashi Y, Okuno T, Nakamura Y, Sakakibara M, Nakayama T, et al. Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation. Circ J 2007; 71: 617-619.
7. Iakovou I, Schmidt T, Bonizzoni E, Ge L, Sangiorgi GM, Stankovic G, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 2005; 293: 2126-2130.
8. Grines CL, Bonow RO, Casey DE Jr, Gardner TJ, Lockhart PB, Moliterno DI, et al. Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents. Circulation 2007; 115: 813-818.
9. Colombo A, Hall P, Nakamura S, Almagor Y, Maiello L, Martini G, et al. Intracoronary stenting without anticoagulation accomplished with intravascular ultrasound guidance. Circulation 1995; 91: 1676-1688.
10. Kitahara H, Kobayashi Y, FujimotoY, Nakamura Y, Nakayama T, Kuroda N, et al. Late stent thrombosis in patients receiving ticlopidine and aspirin after sirolimus-eluting stent implantation. Circ J 2007; 72: 168-169.
11. Denninger MH, Necciari I, Serre-Lacroix E, Sissmann J. Clopidogrel antiplatelet activity is independent of age and presence of atherosclerosis. Semin Thromb Hemost 1999; 25(Suppl 2): 41-45.
12. Angiolillo DJ, Alfonso F. Clopidogrel statin interaction. J Am Coll Cardiol 2007; 50: 296-298.