Metabolite profiling in human urine by LC-MS/MS: Method optimization and application for glucuronides from dextromethorphan metabolism

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 871, Issue 2, 2008, Pages 349-356

  Lutz, Ursula ^a   Bittner, Nataly ^a   Lutz, Roman W ^b   Lutz, Werner K ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

CYP2D6; Dextromethorphan; Drug metabolism; Humans; Liquid chromatography; Mass spectrometry; Metabolite profiling; Metabolomics; Multivariate analysis; Phenotyping; Polymorphism; Urine

Indexed keywords

ANIMAL CELL CULTURE; ARSENIC COMPOUNDS; BIOCHEMISTRY; BIOMOLECULES; BODY FLUIDS; CHEMOTHERAPY; CHROMATOGRAPHIC ANALYSIS; CONCENTRATION (PROCESS); CUSTOMER SATISFACTION; DATA HANDLING; DISCRIMINANT ANALYSIS; DRUG DELIVERY; DRUG DOSAGE; DRUG PRODUCTS; ENZYME ACTIVITY; EXTRACTION; FINANCIAL DATA PROCESSING; FOOD ADDITIVES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; OPTIMIZATION; PLASMAS; PRINCIPAL COMPONENT ANALYSIS; PROBLEM SOLVING; QUALITY ASSURANCE; QUALITY FUNCTION DEPLOYMENT; SENSITIVITY ANALYSIS; SPECTROMETRY; TOTAL QUALITY MANAGEMENT;

ANALYTES; ANIMAL EXPERIMENTATION; BIO-FLUIDS; BIOMONITORING; COLUMN SWITCHING; CONTROL SAMPLES; CREATININE CONCENTRATION; CYTOCHROME P450 (CYP); DATA MATRICES; DATA TRANSFORMATIONS; DEXTROMETHORPHAN (DM); DRUG DEVELOPMENTS; ENVIRONMENTAL EXPOSURES; GLUCURONIDE; GLUCURONIDES; HIGH SENSITIVITY (HS); HUMAN URINE; INDIVIDUAL DIFFERENCES; ION SUPPRESSIONS; LARGE SAMPLE; LC-MS/MS; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC MS MS); METABOLIC PATHWAYS; METABOLITE PROFILING; METABOLIZERS; MULTIPLE REACTION MONITORING; PHARMACOTHERAPY; PRECURSOR ION SCAN; PRINCIPAL COMPONENT ANALYSIS (PCA); REPRODUCIBILITY; RETENTION TIMES; SCALING PROCEDURES; URINE SAMPLES;

QUALITY CONTROL;

CREATININE; CYTOCHROME P450 2D6; DEXTROMETHORPHAN; GLUCURONIDE;

ARTICLE; CLINICAL TRIAL; CREATININE BLOOD LEVEL; DISCRIMINANT ANALYSIS; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME ACTIVITY; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLOMICS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; URINALYSIS;

BIOLOGICAL MARKERS; CHROMATOGRAPHY, LIQUID; CREATININE; DEXTROMETHORPHAN; FEMALE; GLUCURONIDES; HUMANS; MALE; MULTIVARIATE ANALYSIS; TANDEM MASS SPECTROMETRY;

ANIMALIA;

EID: 48749091970     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.04.018     Document Type: Article

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