A cunning stunt: An alternative mechanism of eukaryotic translation initiation

Science Signaling

Volumn 1, Issue 25, 2008, Pages

  Morley, Simon J ^a   Coldwell, Mark J ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA;

ARTICLE; BIOLOGICAL MODEL; CELL DIVISION; CELL FUNCTION; GENETICS; HUMAN; MECHANICAL STRESS; PHYSIOLOGY; PROTEIN SYNTHESIS; RIBOSOME; RNA TRANSLATION; SIGNAL TRANSDUCTION;

CELL DIVISION; CELL PHYSIOLOGY; EUKARYOTIC INITIATION FACTOR-2B; HUMANS; MODELS, GENETIC; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, MESSENGER; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 48649109385     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.125pe32     Document Type: Review

References (20)

1. S. J. Morley, M. J. Coldwell, Matters of life and death: Translation initiation during apoptosis, in Translational Control in Biology and Medicine, M. B. Mathew, J. W. B. Hershey, N. Sonenberg, Eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 2007), pp. 433-458.
2. K. W. Sherrill, R. E. Lloyd, Translation of cIAP2 mRNA is mediated exclusively by a stress-modulated ribosome shunt. Mol. Cell. Biol. 28, 2011-2022 (2008).
3. S. M. Srinivasula, J. D. Ashwell, IAPs: What's in a name. Mol. Cell 30, 123-135 (2008).
4. B. P. Eckelman, G. S. Salvesen, The human antiapoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J. Biol. Chem. 281, 3254-3260 (2006).
5. H. Zhou, M. Q. Du, V. M. Dixit, Constitutive NF-κB activation by the t(11:18)(q21;2q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity. Cancer Cell 7, 425-431 (2005).
6. K. A. Spriggs, M. Stoneley, M. Bushell, A. E. Willis, Re-programming of translation following cell stress allows IRES-mediated translation to predominate. Biol. Cell 100, 27-38 (2008).
7. C. G. Proud, Signalling to translation: How signal transduction pathways control the protein synthetic machinery. Biochem. J. 403, 217-234 (2007).
8. M. Holcik, N. Sonenberg, Translational control in stress and apoptosis. Nat. Rev. Mol. Cell Biol. 6, 318-327 (2005).
9. T. A. Poyry, A. Kaminski, E. J. Connell, C. S. Fraser, R. J. Jackson, The mechanism of an exceptional case of reinitiation after translation of a long ORF reveals why such events do not generally occur in mammalian mRNA translation. Genes Dev. 21, 3149-3162 (2007).
10. D. R. Morris, A. P. Geballe, Upstream open reading frames as regulators of mRNA translation. Mol. Cell. Biol. 20, 8635-8642 (2000).
11. L. A. Ryabova, T. Hohn, Ribosome shunting in the cauliflower mosaic virus 35S RNA leader is a special case of reinitiation of translation functioning in plant and animal systems. Genes Dev. 14, 817-829 (2000).
12. M. Hemmings-Mieszczak, T. Hohn, A stable hairpin preceded by a short open reading frame promotes nonlinear ribosome migration on a synthetic mRNA leader.RNA 5, 1149-1157 (1999).
13. A. Yueh, R. J. Schneider, Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells. Genes Dev. 10, 1557-1567 (1996).
14. S. de Breyne, V. Simonet, T. Pelet, J. Curran, Identification of a cis-acting element required for shunt-mediated translational initiation of the Sendai virus Y proteins. Nucleic Acids Res. 31, 608-618 (2003).
15. M. M. Pooggin, L. A. Ryabova, X. He, J. Futterer, T. Hohn, Mechanism of ribosome shunting in Rice tungro bacilliform pararetrovirus. RNA 12, 841-850 (2006).
16. H. S. Park, A. Himmelbach, K. S. Browning, T. Hohn, L. A. Ryabova, A plant viral "reinitiation" factor interacts with the host translational machinery. Cell 106, 723-733 (2001).
17. H. S. Park, K. S. Browning, T. Hohn, L. A. Ryabova, Eucaryotic initiation factor 4B controls eIF3- mediated ribosomal entry of viral reinitiation factor. EMBO J. 23, 1381-1391 (2004).
18. A. Yueh, R. J. Schneider, Translation by ribosome shunting on adenovirus and hsp70 mRNAs facilitated by complementarity to 18S rRNA. Genes Dev. 14, 414-421 (2000).
19. E. Damoc, C. S. Fraser, M. Zhou, H. Videler, G. L. Mayeur, J.W. Hershey, J. A. Doudna, C. V. Robinson, J. A. Leary, Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol. Cell. Proteomics 6, 1135-1146 (2007).
20. S. A. Chappell, J. Dresios, G. M. Edelman, V. P. Mauro, Ribosomal shunting mediated by a translational enhancer element that base pairs to 18S rRNA. Proc. Natl. Acad. Sci. U.S.A. 103, 9488-9493 (2006).