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Volumn 87, Issue 9, 2008, Pages 727-734

Prolonged haematological toxicity from the hyper-CVAD regimen: Manifestations, frequency, and natural history in a cohort of 125 consecutive patients

Author keywords

Hyper CVAD; Therapy related acute myeloid leukaemia; Therapy related myelodysplasia

Indexed keywords

ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOTOXIC AGENT; DEXAMETHASONE; DOXORUBICIN; ERYTHROPOIETIN; MERCAPTOPURINE; METHOTREXATE; PREDNISOLONE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RITUXIMAB; VINCRISTINE;

EID: 48649106035     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-008-0488-6     Document Type: Article
Times cited : (14)

References (30)
  • 9
    • 33845693025 scopus 로고    scopus 로고
    • The hyper-CVAD-rituximab chemotherapy programme followed by high-dose busulfan, melphalan and autologous stem cell transplantation produces excellent event-free survival in patients with previously untreated mantle cell lymphoma
    • Ritchie DS, Seymour JF, Grigg AP, Roberts AW, Hoyt R, Thompson S, Szer J, Prince HM (2007) The hyper-CVAD-rituximab chemotherapy programme followed by high-dose busulfan, melphalan and autologous stem cell transplantation produces excellent event-free survival in patients with previously untreated mantle cell lymphoma. Ann Hematol 86:101-105
    • (2007) Ann Hematol , vol.86 , pp. 101-105
    • Ritchie, D.S.1    Seymour, J.F.2    Grigg, A.P.3    Roberts, A.W.4    Hoyt, R.5    Thompson, S.6    Szer, J.7    Prince, H.M.8
  • 10
    • 0042424858 scopus 로고    scopus 로고
    • Complete remission in advanced blastic NK-cell lymphoma/leukemia in elderly patients using the hyper-CVAD regimen
    • (S-Plus 2000 User's Guide, Data Analysis Products Division, MathSoft, Seattle, WA)
    • Shapiro M, Wasik MA, Junkins-Hopkins JM, Rook AH, Vittorio CC, Itakura H, Frankel MC, Georgala S, Schuster SJ (2003) Complete remission in advanced blastic NK-cell lymphoma/leukemia in elderly patients using the hyper-CVAD regimen. Am J Hematol 74:46-51 (S-Plus 2000 User's Guide, Data Analysis Products Division, MathSoft, Seattle, WA)
    • (2003) Am J Hematol , vol.74 , pp. 46-51
    • Shapiro, M.1    Wasik, M.A.2    Junkins-Hopkins, J.M.3    Rook, A.H.4    Vittorio, C.C.5    Itakura, H.6    Frankel, M.C.7    Georgala, S.8    Schuster, S.J.9
  • 11
    • 33749243130 scopus 로고    scopus 로고
    • The hyper-CVAD chemotherapy regimen has an adverse long-term impact on the ability to mobilise peripheral blood stem cells, which can be readily circumvented by using the early cycles for mobilisation
    • Keane C, Gibbs S, Seymour JF, Mills AK, Grimmett K, Van Kuilenberg R, Saal R, Gill D, Prince HM, Marlton P, Mollee P (2006) The hyper-CVAD chemotherapy regimen has an adverse long-term impact on the ability to mobilise peripheral blood stem cells, which can be readily circumvented by using the early cycles for mobilisation. Hematol Oncol 24:159-163
    • (2006) Hematol Oncol , vol.24 , pp. 159-163
    • Keane, C.1    Gibbs, S.2    Seymour, J.F.3    Mills, A.K.4    Grimmett, K.5    Van Kuilenberg, R.6    Saal, R.7    Gill, D.8    Prince, H.M.9    Marlton, P.10    Mollee, P.11
  • 13
    • 0038305924 scopus 로고    scopus 로고
    • Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: The University of Chicago series
    • Smith SM, Le Beau MM, Hou D, Karrison T, Sobecks RM, Anastasi J, Vardiman JW, Rowley JD, Larson RA (2003) Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: The University of Chicago series. Blood 102:43-52
    • (2003) Blood , vol.102 , pp. 43-52
    • Smith, S.M.1    Le Beau, M.M.2    Hou, D.3    Karrison, T.4    Sobecks, R.M.5    Anastasi, J.6    Vardiman, J.W.7    Rowley, J.D.8    Larson, R.A.9
  • 14
    • 0034210220 scopus 로고    scopus 로고
    • Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation
    • Pedersen-Bjergaard J, Andersen MK, Christiansen DH (2000) Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation. Blood 95:3273-3279
    • (2000) Blood , vol.95 , pp. 3273-3279
    • Pedersen-Bjergaard, J.1    Andersen, M.K.2    Christiansen, D.H.3
  • 15
    • 16244362857 scopus 로고    scopus 로고
    • Moderate increase of secondary hematologic malignancies after myeloablative radiochemotherapy and autologous stem-cell transplantation in patients with indolent lymphoma: Results of a prospective trial of the German low grade lymphoma study group
    • Lenz G, Dreyling M, Scheignitz E, Haferlach T, Hasford J, Unterhalt M, Hiddemann W (2004) Moderate increase of secondary hematologic malignancies after myeloablative radiochemotherapy and autologous stem-cell transplantation in patients with indolent lymphoma: Results of a prospective trial of the German low grade lymphoma study group. J Clin Oncol 22:4926-4933
    • (2004) J Clin Oncol , vol.22 , pp. 4926-4933
    • Lenz, G.1    Dreyling, M.2    Scheignitz, E.3    Haferlach, T.4    Hasford, J.5    Unterhalt, M.6    Hiddemann, W.7
  • 16
    • 16844382731 scopus 로고    scopus 로고
    • Insights into leukemogenesis from therapy-related leukemia
    • Pedersen-Bjergaard J (2005) Insights into leukemogenesis from therapy-related leukemia. N Engl J Med 352:1591-1594
    • (2005) N Engl J Med , vol.352 , pp. 1591-1594
    • Pedersen-Bjergaard, J.1
  • 18
    • 48649090776 scopus 로고    scopus 로고
    • Cancer Council Victoria. Available from: (accessed April 22)
    • Cancer Council Victoria. Clinical trials reference information. Available from: http://www.cancervic.org.au/trials/details.asp?ContentID= nhl11 (accessed April 22, 2007)
    • (2007) Clinical Trials Reference Information
  • 19
    • 33750432899 scopus 로고    scopus 로고
    • Safety and efficacy of pegfilgrastim compared to granulocyte colony stimulating factor (G-CSF) supporting a dose-intensive, rapidly cycling anti-metabolite containing chemotherapy regimen (hyper-CVAD) for lymphoid malignancy
    • Lane SW, Crawford J, Kenealy M, Cull G, Seymour JF, Prince HM, Marlton P, Gill D, Mollee PN (2006) Safety and efficacy of pegfilgrastim compared to granulocyte colony stimulating factor (G-CSF) supporting a dose-intensive, rapidly cycling anti-metabolite containing chemotherapy regimen (hyper-CVAD) for lymphoid malignancy. Leuk Lymphoma 47:1813-1817
    • (2006) Leuk Lymphoma , vol.47 , pp. 1813-1817
    • Lane, S.W.1    Crawford, J.2    Kenealy, M.3    Cull, G.4    Seymour, J.F.5    Prince, H.M.6    Marlton, P.7    Gill, D.8    Mollee, P.N.9
  • 22
    • 0029851283 scopus 로고    scopus 로고
    • A note on quantifying follow-up in studies of failure time
    • Schemper M, Smith TL (1996) A note on quantifying follow-up in studies of failure time. Control Clin Trials 17:343-346
    • (1996) Control Clin Trials , vol.17 , pp. 343-346
    • Schemper, M.1    Smith, T.L.2
  • 24
    • 33746277276 scopus 로고    scopus 로고
    • Delayed-onset peripheral blood cytopenias after rituximab: Frequency and risk factor assessment in a consecutive series of 77 treatments
    • Cattaneo C, Spedini P, Casari S, Re A, Tucci A, Corlenghi E, Ungari M, Ruggeri G, Rossi G (2006) Delayed-onset peripheral blood cytopenias after rituximab: Frequency and risk factor assessment in a consecutive series of 77 treatments. Leuk Lymphoma 47:1013-1017
    • (2006) Leuk Lymphoma , vol.47 , pp. 1013-1017
    • Cattaneo, C.1    Spedini, P.2    Casari, S.3    Re, A.4    Tucci, A.5    Corlenghi, E.6    Ungari, M.7    Ruggeri, G.8    Rossi, G.9
  • 25
    • 0021883355 scopus 로고
    • Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas: Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents
    • Pedersen-Bjergaard J, Ersboll J, Sorensen HM, Keiding M, Larsen SO, Philip P, Larsen MS, Schultz H, Nissen NI (1985) Risk of acute nonlymphocytic leukemia and preleukemia in patients treated with cyclophosphamide for non-Hodgkin's lymphomas: Comparison with results obtained in patients treated for Hodgkin's disease and ovarian carcinoma with other alkylating agents. Ann Intern Med 103:195-200
    • (1985) Ann Intern Med , vol.103 , pp. 195-200
    • Pedersen-Bjergaard, J.1    Ersboll, J.2    Sorensen, H.M.3    Keiding, M.4    Larsen, S.O.5    Philip, P.6    Larsen, M.S.7    Schultz, H.8    Nissen, N.I.9
  • 26
    • 0020458993 scopus 로고
    • Post-therapeutic acute malignant myeloproliferative syndrome and acute nonlymphocytic leukemia in non-Hodgkin's lymphoma
    • Gomez GA, Aggarwal KK, Han T (1982) Post-therapeutic acute malignant myeloproliferative syndrome and acute nonlymphocytic leukemia in non-Hodgkin's lymphoma. Cancer 50:2285-2288
    • (1982) Cancer , vol.50 , pp. 2285-2288
    • Gomez, G.A.1    Aggarwal, K.K.2    Han, T.3
  • 27
    • 33747061875 scopus 로고    scopus 로고
    • Risk factors before autologous stem-cell transplantation for lymphoma predict for secondary myelodysplasia and acute myelogenous leukemia
    • Kalaycio M, Rybicki L, Pohlman B, Sobecks R, Andresen S, Kuczkowski E, Bolwell B (2006) Risk factors before autologous stem-cell transplantation for lymphoma predict for secondary myelodysplasia and acute myelogenous leukemia. J Clin Oncol 24:3604-3610
    • (2006) J Clin Oncol , vol.24 , pp. 3604-3610
    • Kalaycio, M.1    Rybicki, L.2    Pohlman, B.3    Sobecks, R.4    Andresen, S.5    Kuczkowski, E.6    Bolwell, B.7
  • 29
    • 0025836549 scopus 로고
    • Treatment of adult acute lymphoblastic leukaemia with intensive cyclical chemotherapy: A follow-up report
    • Linker CA, Levitt LJ, O'Donnell M, Forman SJ, Ries CA (1991) Treatment of adult acute lymphoblastic leukaemia with intensive cyclical chemotherapy: A follow-up report. Blood 78:2814-2822
    • (1991) Blood , vol.78 , pp. 2814-2822
    • Linker, C.A.1    Levitt, L.J.2    O'Donnell, M.3    Forman, S.J.4    Ries, C.A.5
  • 30
    • 0037092959 scopus 로고    scopus 로고
    • Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukaemia
    • Linker C, Damon L, Ries C, Navarro W (2002) Intensified and shortened cyclical chemotherapy for adult acute lymphoblastic leukaemia. J Clin Oncol 20:2464-2471
    • (2002) J Clin Oncol , vol.20 , pp. 2464-2471
    • Linker, C.1    Damon, L.2    Ries, C.3    Navarro, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.