Long-Term Treatment With Finasteride Results in a Clinically Significant Reduction in Total Prostate Volume Compared to Placebo Over the Full Range of Baseline Prostate Sizes in Men Enrolled in the MTOPS Trial

Journal of Urology

Volumn 180, Issue 3, 2008, Pages 1030-1033

  Kaplan, Steven A ^a   Roehrborn, Claus G ^b   McConnell, John D ^b   Meehan, Alan G ^c   Surynawanshi, Shailaja ^c   Lee, Jeannette Y ^d   Rotonda, Jennifer ^c   Kusek, John W ^e   Nyberg Jr , Leroy M ^e  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

combined modality therapy; doxazosin; finasteride; prostatic hyperplasia; urinary tract

Indexed keywords

DOXAZOSIN; FINASTERIDE; PLACEBO;

ADULT; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DEMOGRAPHY; HUMAN; LONG TERM CARE; LOWER URINARY TRACT SYMPTOM; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; ORGAN SIZE; PRIORITY JOURNAL; PROSTATE HYPERTROPHY; TRANSRECTAL ULTRASONOGRAPHY; TREATMENT OUTCOME;

ADRENERGIC ALPHA-ANTAGONISTS; AGED; DOXAZOSIN; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; FINASTERIDE; HUMANS; MALE; MIDDLE AGED; PROSTATE; PROSTATIC HYPERPLASIA; TIME FACTORS;

EID: 48649099681     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.juro.2008.05.004     Document Type: Article

References (3)

1. McConnell J.D., Roehrborn C.G., Bautista O.M., Andriole Jr. G.L., Dixon C.M., Kusek J.W., et al. The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. N Engl J Med 349 (2003) 2387
2. AUA Practice Guidelines Committee. AUA guideline on management of benign prostatic hyperplasia (2003). Chapter 1: Diagnosis and treatment recommendations. J Urol 170 (2003) 530
3. Bautista O.M., Kusek J.W., Nyberg L.M., McConnell J.D., Bain R.P., Miller G., et al. Study design of the Medical Therapy of Prostatic Symptoms (MTOPS) trial. Control Clin Trials 24 (2003) 224