Liposomal co-entrapment of CD40mAb induces enhanced IgG responses against bacterial polysaccharide and protein

PLoS ONE

Volumn 3, Issue 6, 2008, Pages

  Hatzifoti, Caterina ^a   Bacon, Andrew ^b   Marriott, Helen ^c   Laing, Peter ^b   Heath, Andrew W ^a,c  

^a Adjuvantix Ltd   (United Kingdom)

^b Lipoxen Technologies Ltd   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; DIPHTHERIA VACCINE; IMMUNOGLOBULIN G; LIPOSOME; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD40; PNEUMOCOCCUS POLYSACCHARIDE; PNEUMOCOCCUS VACCINE; TETANUS TOXOID; CD40 ANTIGEN; LIPOPOLYSACCHARIDE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; ENCAPSULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNOGENICITY; LIPOSOMAL DELIVERY; MOUSE; NONHUMAN; SPLENOMEGALY; STREPTOCOCCUS PNEUMONIAE; TOXICITY TESTING; ANIMAL; BAGG ALBINO MOUSE; IMMUNOLOGY;

BACTERIA (MICROORGANISMS); MUS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; BACTERIAL PROTEINS; FEMALE; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDES; LIPOSOMES; MICE; MICE, INBRED BALB C;

EID: 48649094879     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002368     Document Type: Article

References (21)

1. Xu J, Foy TM, Laman JD, Elliott EA, Dunn JJ, et al. (1994) Mice deficient for the CD40 ligand. Immunity 1: 423-431.
2. Grewal IS, Flavell RA (1996) The role of CD40 ligand in costimulation and T-cell activation. Immunol Rev 153: 85-106.
3. Grewal IS, Xu J, Flavell RA (1995) Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378: 617-620.
4. Dullforce P, Sutton DC, Heath AW (1998) Enhancement of T cell-independent immune responses in vivo by CD40 antibodies. Nat Med 4: 88-91.
5. Barr TA, Heath AW (1999) Enhanced in vivo immune responses to bacterial lipopolysaccharide by exogenous CD40 stimulation. Infect Immun 67: 3637-3640.
6. Barr TA, McCormick AL, Carlring J, Heath AW (2003) A potent adjuvant effect of CD40 antibody attached to antigen. Immunology 109: 87-92.
7. Carlring J, Barr TA, McCormick AL, Heath AW (2004) CD40 antibody as an adjuvant induces enhanced T cell responses. Vaccine 22: 3323-3328.
8. Barr TA, Carlring J, Heath AW (2005) CD40 antibody as a potent immunological adjuvant: CD40 antibody provides the CD40 signal to B cells, but does not substitute for T cell help in responses to TD antigens. Vaccine 23: 3477-3482.
9. Allison AG, Gregoriadis G (1974) Liposomes as immunological adjuvants. Nature 252: 252.
10. Garner CV, Pier GB (1989) Immunologic considerations for the development of conjugate vaccines. Contrib Microbiol Immunol 10: 11-17.
11. Weinberg GA, Granoff DM (1988) Polysaccharide-protein conjugate vaccines for the prevention or Haemophilus influerizae type b disease. J Pediatr 113: 621-631.
12. Klugman KP, Madhi SA, Huebner RE, Kohberger R, Mbelle N, et al. (2003) A trial of a 9-valent pneumococcal conjugate vaccine in children with and those without HIV infection. N Engl J Med 349: 1341-1348.
13. Wessels MR, Kasper DL (1989) Antibody recognition of the type 14 pneumococcal capsule. Evidence for a conformational epitope in a neutral polysaccharide. J Exp Med 169: 2121-2131.
14. Lee CJ, Fraser BA, Szu S, Lin KT (1981) Chemical structure or and immune response to polysaccharides or streptococcus pneumoniae. Rev Infect Dis 3: 323-331.
15. Tutt AL, O'Brien L, Hussain A, Crowther GR, French RR, et al. (2002) T cell immunity to lymphoma following treatment with anti-CD40 monoclonal antibody. J Immunol 168: 2720-2728.
16. Berner V, Liu H, Zhou Q, Alderson KL, Sun K, et al. (2007) IFN-gamma mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful ini ial immunotherapy. Nat Med 13: 351-360.
17. Barr TA, Carlring J, Heath AW (2006) Co-stimulatory agonists as immunological adjuvants. Vaccine 24: 3399-3407.
18. Barr TA, Heath AW (2001) Functional activity of CD40 antibodies correlates to the position of binding relative to CD154. Immunology 102: 39-43.
19. Presky DH, Minetti LJ, Gillessen S, Gubler U, Chizzonite R, et al. (1996) Evidence for multiple sites of interaction between IL-12 and its receptor. Ann N Y Acad Sci 795: 390-393.
20. Kirby CJ, Gregoriadis G (1984) Preparation of liposomes containing factor VIII for oral treatment of haemophilia. J Microencapsul 1: 33-45.
21. Randall TD, Heath AW, Santos-Argumedo L, Howard MC, Weissman IL, et al. (1998) Arrest or B lymphocyte terminal differentiation by CD40 signaling: mechanism for lack of antibody-secreting cells in germinal centers. Immunity 8: 733-742.