Biorelevant refinement of the Caco-2 cell culture model to assess efficacy of paracellular permeability enhancers

Journal of Pharmaceutical Sciences

Volumn 97, Issue 5, 2008, Pages 1977-1992

  Tippin, Timothy K ^a,b   Thakker, Dhiren R ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

absorption enhancer; Caco 2 cells; hexadecylphosphocholine; in vivo in vitro correlations (IVIVC); intestinal absorption; palmitoylcarnitine chloride; paracellular permeability enhancer; paracellular transport; sodium caprate; tight junction

Indexed keywords

3 NITROCOUMARIN; BUFFER; CARNITINE; CARNITINE DERIVATIVE; COUMARIN DERIVATIVE; DECANOATE SODIUM; EDETIC ACID; MANNITOL; MILTEFOSINE; PALMITOYL CARNITINE CHLORIDE; SODIUM DERIVATIVE; UNCLASSIFIED DRUG; WATER; DRUG DERIVATIVE; PALMITOYLCARNITINE; PHOSPHORYLCHOLINE;

AGITATION; ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; INTESTINE FLUID; MONOLAYER CULTURE; SERUM; SIMULATION; DRUG EFFECT; IMPEDANCE; INTESTINE ABSORPTION; METABOLISM; PERMEABILITY;

CACO-2 CELLS; ELECTRIC IMPEDANCE; HUMANS; INTESTINAL ABSORPTION; PALMITOYLCARNITINE; PERMEABILITY; PHOSPHORYLCHOLINE;

EID: 48549105857     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21118     Document Type: Article

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