Phosphatidylserine prevents UV-induced decrease of type I procollagen and increase of MMP-1 in dermal fibroblasts and human skin in vivo

Journal of Lipid Research

Volumn 49, Issue 6, 2008, Pages 1235-1245

  Cho, Soyun ^a,b,c   Kim, Hyeon Ho ^a,b,c   Lee, Min Jung ^a,b,c   Lee, Serah ^a,b,c   Park, Chang Seo ^d   Nam, Sang June ^e   Han, Jeong Jun ^e   Kim, Jin Wook ^e   Chung, Jin Ho ^a,b,c  

^a Seoul National University College of Medicine   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University   (South Korea)

^d Dongguk University   (South Korea)

^e Doosan Biotech Division   (South Korea)

Author keywords

Intrinsic aging; Matrix metalloproteinase 1; Photoaging; Ultraviolet

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHATIDYLSERINE; MESSENGER RNA; N ACETYL PHYTOSPHINGOSINE; PHOSPHATIDYLSERINE; PROCOLLAGEN; SPHINGOSINE DERIVATIVE; TETRAACETYL PHYTOSPHINGOSINE; UNCLASSIFIED DRUG; COLLAGEN TYPE 1; INTERLEUKIN 1ALPHA; PRIMER DNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; AGING; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CUTANEOUS PARAMETERS; DERMIS; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INHIBITION KINETICS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SKIN; SKIN FIBROBLAST; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION; WESTERN BLOTTING; CELL CULTURE; CYTOLOGY; ENZYMOLOGY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

BASE SEQUENCE; BLOTTING, WESTERN; CELLS, CULTURED; COLLAGEN TYPE I; CYCLOOXYGENASE 2; DNA PRIMERS; FIBROBLASTS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1ALPHA; INTERLEUKIN-6; MATRIX METALLOPROTEINASE 1; PHOSPHATIDYLSERINES; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SKIN; TUMOR NECROSIS FACTOR-ALPHA; ULTRAVIOLET RAYS;

EID: 48549103705     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700581-JLR200     Document Type: Article

References (29)

1. Gilchrest, B. 1989. Skin aging and photoaging: an overview. J. Am. Acad. Dermatol. 21: 610-613.
2. Fisher, G., Z. Wang, S. Datta, J. Varani, S. Kang, and J. Voorhees. 1997. Pathophysiology of premature skin aging induced by ultraviolet light. N. Engl. J. Med. 337: 1419-1428.
3. Fisher, G., S. Datta, H. Talwar, Z. Wang, J. Varani, S. Kang, and J. Voorhees. 1996. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature. 379: 335-339. (Pubitemid 26033074)
4. Gupta, A. K., G. J. Fisher, J. T. Elder, B. J. Nickoloff, and J. J. Voorhees. 1988. Sphingosine inhibits phorbol ester-induced inflammation, ornithine decarboxylase activity, and activation of protein kinase C in mouse skin. J. Invest. Dermatol. 91: 486-491.
5. Kim, S., I. Hong, J. S. Hwang, J. K. Choi, H. S. Rho, D. H. Kim, I. Chang, S. H. Lee, M. O. Lee, and J. S. Hwang. 2006. Phytosphingosine stimulates the differentiation of human keratinocytes and inhibits TPA-induced inflammatory epidermal hyperplasia in hairless mouse skin. Mol Med. 12: 17-24. (Pubitemid 44128374)
6. Goetzl, E. J., and S. An. 1998. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J. 12: 1589-1598.
7. Balazs, L., J. Okolicany, M. Ferrebee, B. Tolley, and G. Tigyi. 2001. Topical application of the phospholipid growth factor lysophosphatidic acid promotes wound healing in vivo. Am. J. Physiol. 280: R466-R472.
8. Ryu, S. B., and J. P. Palta. 2000. Specific inhibition of rat brain phospholipase D by lysophospholipids. J. Lipid Res. 41: 940-944. (Pubitemid 30434325)
9. Vance, J., and R. Steenbergen. 2005. Metabolism and functions of phosphatidylserine. Prog. Lipid Res. 44: 207-234.
10. Shvedova, A., J. Tyurina, K. Kawai, V. Tyurin, C. Kommineni, V. Castranova, J. Fabisiak, and V. Kagan. 2002. Selective peroxidation and externalization of phosphatidylserine in normal human epidermal keratinocytes during oxidative stress induced by cumene hydroperoxide. J. Invest. Dermatol. 118: 1008-1018.
11. Martin, S. J., C. P. Reutelingsperger, A. J. McGahon, J. A. Rader, R. C. van Schie, D. M. LaFace, and D. R. Green. 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182: 1545-1556.
12. Fadok, V. A., D. L. Bratton, D. M. Rose, A. Pearson, R. A. Ezekewitz, and P. M. Henson. 2000. A receptor for phosphatidylserine-specific clearance of apoptotic cells. Nature. 405: 85-90. (Pubitemid 30321820)
13. Dacaranhe, C. D., and J. Terao. 2001. A unique antioxidant activity of phosphatidylserine on iron-induced lipid peroxidation of phospholipid bilayers. Lipids. 36: 1105-1110. (Pubitemid 33143964)
14. Van Veldhoven, P. P., G. P. Mannaerts, P. Declercq, and M. Baes. 2000. Do sphingoid bases interact with the peroxisome proliferator activated receptor alpha (PPAR-alpha)? Cell. Signal. 12: 475-479.
15. Kuenzli, S., and J. H. Saurat. 2003. Peroxisome proliferator-activated receptors in cutaneous biology. Br. J. Dermatol. 149: 229-236.
16. Kippenberger, S., S. M. Loitsch, M. Grundmann-Kollmann, S. Simon, T. A. Dang, K. Hardt-Weinelt, R. Kaufmann, and A. Bernd. 2001. Activators of peroxisome proliferator-activated receptors protect human skin from ultraviolet-B-light-induced inflammation. J. Invest. Dermatol. 117: 1430-1436.
17. Seo, J. Y., E. K. Kim, S. H. Lee, K. C. Park, K. H. Kim, H. C. Eun, and J. H. Chung. 2003. Enhanced expression of cylooxygenase-2 by UV in aged human skin in vivo. Mech. Ageing Dev. 124: 903-910.
18. Seo, J. Y., S. H. Lee, C. S. Youn, H. R. Choi, G. E. Rhie, K. H. Cho, K. H. Kim, K. C. Park, H. C. Eun, and J. H. Chung. 2001. Ultraviolet radiation increases tropoelastin mRNA expression in the epidermis of human skin in vivo. J. Invest. Dermatol. 116: 915-919.
19. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25: 402-408. (Pubitemid 34164012)
20. Son, E. D., J. Y. Lee, S. Lee, M. S. Kim, B. G. Lee, I. S. Chang, and J. H. Chung. 2005. Topical application of 17beta-estradiol increases extracellular matrix protein synthesis by stimulating tgf-Beta signaling in aged human skin in vivo. J. Invest. Dermatol. 124: 1149-1161.
21. Kim, H. J., H. J. Kim, S. C. Lim, S. H. Kim, and T. Y. Kim. 2003. Induction of apoptosis and expression of cell cycle regulatory proteins in response to a phytosphingosine derivative in HaCaT human keratinocyte cells. Mol. Cells. 16: 331-337.
22. Varani, J., R. L. Warner, M. Gharaee-Kermani, S. H. Phan, S. Kang, J. H. Chung, Z. Q. Wang, S. C. Datta, G. J. Fisher, and J. J. Voorhees. 2000. Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin. J. Invest. Dermatol. 114: 480-486.
23. Kang, S., G. J. Fisher, and J. J. Voorhees. 2001. Photoaging: pathogenesis, prevention, and treatment. Clin. Geriatr. Med. 17: 643-659.
24. Huynh, M. L., V. A. Fadok, and P. M. Henson. 2002. Phosphatidylserine- dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J. Clin. Invest. 109: 41-50.
25. Kupper, T. S. 1989. Mechanisms of cutaneous inflammation. Interactions between epidermal cytokines, adhesion molecules, and leukocytes. Arch. Dermatol. 125: 1406-1412.
26. Urbanski, A., T. Schwarz, P. Neuner, J. Krutmann, R. Kirnbauer, A. Kock, and T. A. Luger. 1990. Ultraviolet light induces increased circulating interleukin-6 in humans. J. Invest. Dermatol. 94: 808-811.
27. Oxholm, A., P. Oxholm, B. Staberg, and K. Bendtzen. 1988. Immunohistological detection of interleukin I-like molecules and tumour necrosis factor in human epidermis before and after UVB-irradiation in vivo. Br. J. Dermatol. 118: 369-376.
28. Sheu, M. Y., A. J. Fowler, J. Kao, M. Schmuth, K. Schoonjans, J. Auwerx, J. W. Fluhr, M. Q. Man, P. M. Elias, and K. R. Feingold. 2002. Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J. Invest. Dermatol. 118: 94-101.
29. Delerive, P., K. De Bosscher, S. Besnard, W. Vanden Berghe, J. M. Peters, F. J. Gonzalez, J. C. Fruchart, A. Tedgui, G. Haegeman, and B. Staels. 1999. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP-1. J. Biol. Chem. 274: 32048-32054.