-
1
-
-
0028143212
-
Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis
-
Elliott M.J., Maini R.N., Feldmann M., Long-Fox A., Charles P., Bijl H., and Woody J.N. Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis. Lancet 344 (1994) 1125-1127
-
(1994)
Lancet
, vol.344
, pp. 1125-1127
-
-
Elliott, M.J.1
Maini, R.N.2
Feldmann, M.3
Long-Fox, A.4
Charles, P.5
Bijl, H.6
Woody, J.N.7
-
2
-
-
0013511183
-
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
-
Moreland L.W., Baumgartner S.W., Schiff M.H., Tindall E.A., Fleischmann R.M., Weaver A.L., Ettlinger R.E., Cohen S., Koopman W.J., Mohler K., et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 337 (1997) 141-147
-
(1997)
N Engl J Med
, vol.337
, pp. 141-147
-
-
Moreland, L.W.1
Baumgartner, S.W.2
Schiff, M.H.3
Tindall, E.A.4
Fleischmann, R.M.5
Weaver, A.L.6
Ettlinger, R.E.7
Cohen, S.8
Koopman, W.J.9
Mohler, K.10
-
3
-
-
0031660364
-
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
-
Maini R.N., Breedveld F.C., Kalden J.R., Smolen J.S., Davis D., Macfarlane J.D., Antoni C., Leeb B., Elliott M.J., Woody J.N., et al. Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 41 (1998) 1552-1563
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1552-1563
-
-
Maini, R.N.1
Breedveld, F.C.2
Kalden, J.R.3
Smolen, J.S.4
Davis, D.5
Macfarlane, J.D.6
Antoni, C.7
Leeb, B.8
Elliott, M.J.9
Woody, J.N.10
-
4
-
-
0037231533
-
Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial
-
Weinblatt M.E., Keystone E.C., Furst D.E., Moreland L.W., Weisman M.H., Birbara C.A., Teoh L.A., Fischkoff S.A., and Chartash E.K. Adalimumab, a fully human anti-tumor necrosis factor alpha monoclonal antibody, for the treatment of rheumatoid arthritis in patients taking concomitant methotrexate: the ARMADA trial. Arthritis Rheum 48 (2003) 35-45
-
(2003)
Arthritis Rheum
, vol.48
, pp. 35-45
-
-
Weinblatt, M.E.1
Keystone, E.C.2
Furst, D.E.3
Moreland, L.W.4
Weisman, M.H.5
Birbara, C.A.6
Teoh, L.A.7
Fischkoff, S.A.8
Chartash, E.K.9
-
5
-
-
38549176118
-
Tumor necrosis factor antagonist mechanisms of action: a comprehensive review
-
Extensive and complete review covering all aspects of anti-TNF therapy.
-
Tracey D., Klareskog L., Sasso E.H., Salfeld J.G., and Tak P.P. Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. Pharmacol Ther 117 (2008) 244-279. Extensive and complete review covering all aspects of anti-TNF therapy.
-
(2008)
Pharmacol Ther
, vol.117
, pp. 244-279
-
-
Tracey, D.1
Klareskog, L.2
Sasso, E.H.3
Salfeld, J.G.4
Tak, P.P.5
-
6
-
-
33744950980
-
Scientific and regulatory considerations on the immunogenicity of biologics
-
Shankar G., Shores E., Wagner C., and Mire-Sluis A. Scientific and regulatory considerations on the immunogenicity of biologics. Trends Biotechnol 24 (2006) 274-280
-
(2006)
Trends Biotechnol
, vol.24
, pp. 274-280
-
-
Shankar, G.1
Shores, E.2
Wagner, C.3
Mire-Sluis, A.4
-
7
-
-
0037434552
-
Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
-
Baert F., Noman M., Vermeire S., Van Assche G., D' Haens G., Carbonez A., and Rutgeerts P. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med 348 (2003) 601-608
-
(2003)
N Engl J Med
, vol.348
, pp. 601-608
-
-
Baert, F.1
Noman, M.2
Vermeire, S.3
Van Assche, G.4
D' Haens, G.5
Carbonez, A.6
Rutgeerts, P.7
-
8
-
-
17644378667
-
Immunogenicity of engineered antibodies
-
Hwang W.Y., and Foote J. Immunogenicity of engineered antibodies. Methods 36 (2005) 3-10
-
(2005)
Methods
, vol.36
, pp. 3-10
-
-
Hwang, W.Y.1
Foote, J.2
-
9
-
-
17044432625
-
Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profiles
-
Anderson P.J. Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profiles. Semin Arthritis Rheum 34 (2005) 19-22
-
(2005)
Semin Arthritis Rheum
, vol.34
, pp. 19-22
-
-
Anderson, P.J.1
-
10
-
-
0028867151
-
Localization of an Fc-binding reactivity to the constant region of human IgG4. Implications for the pathogenesis of rheumatoid arthritis
-
Zack D.J., Stempniak M., Wong A.L., and Weisbart R.H. Localization of an Fc-binding reactivity to the constant region of human IgG4. Implications for the pathogenesis of rheumatoid arthritis. J Immunol 155 (1995) 5057-5063
-
(1995)
J Immunol
, vol.155
, pp. 5057-5063
-
-
Zack, D.J.1
Stempniak, M.2
Wong, A.L.3
Weisbart, R.H.4
-
11
-
-
0001743382
-
Anti-gamma-globulin factors in human sera revealed by enzymatic splitting of anti-Rh antibodies
-
Osterland C.K., Harboe M., and Kunkel H.G. Anti-gamma-globulin factors in human sera revealed by enzymatic splitting of anti-Rh antibodies. Vox Sang 8 (1963) 133-152
-
(1963)
Vox Sang
, vol.8
, pp. 133-152
-
-
Osterland, C.K.1
Harboe, M.2
Kunkel, H.G.3
-
12
-
-
0013855906
-
Observations on antigamma globulin factors in human sera and antibodies against autologous gamma globulins produced in rabbits
-
Williams R.C., and Kunkel H.G. Observations on antigamma globulin factors in human sera and antibodies against autologous gamma globulins produced in rabbits. Ann NY Acad Sci 124 (1965) 860-864
-
(1965)
Ann NY Acad Sci
, vol.124
, pp. 860-864
-
-
Williams, R.C.1
Kunkel, H.G.2
-
13
-
-
0021838045
-
Anti-Fab antibodies in humans. Predominance of minor immunoglobulin G subclasses in rheumatoid arthritis
-
Persselin J.E., and Stevens R.H. Anti-Fab antibodies in humans. Predominance of minor immunoglobulin G subclasses in rheumatoid arthritis. J Clin Invest 76 (1985) 723-730
-
(1985)
J Clin Invest
, vol.76
, pp. 723-730
-
-
Persselin, J.E.1
Stevens, R.H.2
-
14
-
-
33847167546
-
Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis
-
Zhou H., Jang H., Fleischmann R.M., Bouman-Thio E., Xu Z., Marini J.C., Pendley C., Jiao Q., Shankar G., Marciniak S.J., et al. Pharmacokinetics and safety of golimumab, a fully human anti-TNF-alpha monoclonal antibody, in subjects with rheumatoid arthritis. J Clin Pharmacol 47 (2007) 383-396
-
(2007)
J Clin Pharmacol
, vol.47
, pp. 383-396
-
-
Zhou, H.1
Jang, H.2
Fleischmann, R.M.3
Bouman-Thio, E.4
Xu, Z.5
Marini, J.C.6
Pendley, C.7
Jiao, Q.8
Shankar, G.9
Marciniak, S.J.10
-
16
-
-
34548694517
-
Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange
-
van der Neut Kolfschoten M., Schuurman J., Losen M., Bleeker W.K., Martínez-Martínez P., Vermeulen E., den Bleker T.H., Wiegman L., Vink T., Aarden L.A., et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science 317 (2007) 1554-1557
-
(2007)
Science
, vol.317
, pp. 1554-1557
-
-
van der Neut Kolfschoten, M.1
Schuurman, J.2
Losen, M.3
Bleeker, W.K.4
Martínez-Martínez, P.5
Vermeulen, E.6
den Bleker, T.H.7
Wiegman, L.8
Vink, T.9
Aarden, L.A.10
-
17
-
-
0020700160
-
Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response
-
Aalberse R.C., van der Gaag R., and van Leeuwen J. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol 130 (1983) 722-726
-
(1983)
J Immunol
, vol.130
, pp. 722-726
-
-
Aalberse, R.C.1
van der Gaag, R.2
van Leeuwen, J.3
-
18
-
-
48549102797
-
Immunogenicity of anti-TNF antibodies
-
van de Weert M., and Møller E.H. (Eds), Springer
-
Bendtzen K. Immunogenicity of anti-TNF antibodies. In: van de Weert M., and Møller E.H. (Eds). Immunogenicity of Biopharmaceuticals (2008), Springer 189-203
-
(2008)
Immunogenicity of Biopharmaceuticals
, pp. 189-203
-
-
Bendtzen, K.1
-
19
-
-
33644931095
-
Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis
-
First demonstration in rheumatoid arthritis patients that antibodies to the TmAb interfere with clinical efficacy.
-
Wolbink G.J., Vis M., Lems W., Voskuyl A.E., de Groot E., Nurmohamed M.T., Stapel S., Tak P.P., Aarden L., and Dijkmans B. Development of antiinfliximab antibodies and relationship to clinical response in patients with rheumatoid arthritis. Arthritis Rheum 54 (2006) 711-715. First demonstration in rheumatoid arthritis patients that antibodies to the TmAb interfere with clinical efficacy.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 711-715
-
-
Wolbink, G.J.1
Vis, M.2
Lems, W.3
Voskuyl, A.E.4
de Groot, E.5
Nurmohamed, M.T.6
Stapel, S.7
Tak, P.P.8
Aarden, L.9
Dijkmans, B.10
-
20
-
-
33845660797
-
Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab
-
Bendtzen K., Geborek P., Svenson M., Larsson L., Kapetanovic M.C., and Saxne T. Individualized monitoring of drug bioavailability and immunogenicity in rheumatoid arthritis patients treated with the tumor necrosis factor alpha inhibitor infliximab. Arthritis Rheum 54 (2006) 3782-3789
-
(2006)
Arthritis Rheum
, vol.54
, pp. 3782-3789
-
-
Bendtzen, K.1
Geborek, P.2
Svenson, M.3
Larsson, L.4
Kapetanovic, M.C.5
Saxne, T.6
-
21
-
-
34548192177
-
Decreased clinical response to infliximab in ankylosing spondylitis is correlated with anti-infliximab formation
-
de Vries M.K., Wolbink G.J., Stapel S.O., de Vrieze H., van Denderen J.C., Dijkmans B.A., Aarden L.A., and van der Horst-Bruinsma I.E. Decreased clinical response to infliximab in ankylosing spondylitis is correlated with anti-infliximab formation. Ann Rheum Dis 66 (2007) 1252-1254
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 1252-1254
-
-
de Vries, M.K.1
Wolbink, G.J.2
Stapel, S.O.3
de Vrieze, H.4
van Denderen, J.C.5
Dijkmans, B.A.6
Aarden, L.A.7
van der Horst-Bruinsma, I.E.8
-
22
-
-
34347267600
-
Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis
-
Bartelds G.M., Wijbrandts C.A., Nurmohamed M.T., Stapel S., Lems W.F., Aarden L., Dijkmans B.A., Tak P.P., and Wolbink G.J. Clinical response to adalimumab: relationship to anti-adalimumab antibodies and serum adalimumab concentrations in rheumatoid arthritis. Ann Rheum Dis 66 (2007) 921-926
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 921-926
-
-
Bartelds, G.M.1
Wijbrandts, C.A.2
Nurmohamed, M.T.3
Stapel, S.4
Lems, W.F.5
Aarden, L.6
Dijkmans, B.A.7
Tak, P.P.8
Wolbink, G.J.9
-
23
-
-
48549105288
-
-
de Vries MK, van der Horst-Bruinsma IE, Nurmohamed MT, Aarden LA, Stapel SO, Peters MJ, Van Denderen JC, Dijkmans BA, Wolbink GJ: Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis (AS). Ann Rheum Dis 2008, in press.
-
de Vries MK, van der Horst-Bruinsma IE, Nurmohamed MT, Aarden LA, Stapel SO, Peters MJ, Van Denderen JC, Dijkmans BA, Wolbink GJ: Immunogenicity does not influence treatment with etanercept in patients with ankylosing spondylitis (AS). Ann Rheum Dis 2008, in press.
-
-
-
-
24
-
-
8644234910
-
Antibody pharmacokinetics and pharmacodynamics
-
Lobo E.D., Hansen R.J., and Balthasar J.P. Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci 93 (2004) 2645-2668
-
(2004)
J Pharm Sci
, vol.93
, pp. 2645-2668
-
-
Lobo, E.D.1
Hansen, R.J.2
Balthasar, J.P.3
-
25
-
-
33846855387
-
Imaging and serum analysis of immune complex formation of radiolabelled infliximab and anti-infliximab in responders and non-responders to therapy for rheumatoid arthritis
-
In this study the fate of 99Tc-labeled infliximab is studied in RA patients with and without HACAs.
-
Van der Laken C.J., Voskuyl A.E., Roos J.C., Stigter van Walsum M., de Groot E.R., Wolbink G., Dijkmans B.A., and Aarden L.A. Imaging and serum analysis of immune complex formation of radiolabelled infliximab and anti-infliximab in responders and non-responders to therapy for rheumatoid arthritis. Ann Rheum Dis 66 (2007) 253-256. In this study the fate of 99Tc-labeled infliximab is studied in RA patients with and without HACAs.
-
(2007)
Ann Rheum Dis
, vol.66
, pp. 253-256
-
-
Van der Laken, C.J.1
Voskuyl, A.E.2
Roos, J.C.3
Stigter van Walsum, M.4
de Groot, E.R.5
Wolbink, G.6
Dijkmans, B.A.7
Aarden, L.A.8
-
26
-
-
24344448252
-
An acid dissociation bridging ELISA for detection of antibodies directed against therapeutic proteins in the presence of antigen
-
Patton A., Mullenix M.C., Swanson S.J., and Koren E. An acid dissociation bridging ELISA for detection of antibodies directed against therapeutic proteins in the presence of antigen. J Immunol Methods 304 (2005) 189-195
-
(2005)
J Immunol Methods
, vol.304
, pp. 189-195
-
-
Patton, A.1
Mullenix, M.C.2
Swanson, S.J.3
Koren, E.4
-
27
-
-
30844473493
-
Detection of neutralizing anti-therapeutic protein antibodies in serum or plasma samples containing high levels of the therapeutic protein
-
Lofgren J.A., Wala I., Koren E., Swanson S.J., and Jing S. Detection of neutralizing anti-therapeutic protein antibodies in serum or plasma samples containing high levels of the therapeutic protein. J Immunol Methods 308 (2006) 101-108
-
(2006)
J Immunol Methods
, vol.308
, pp. 101-108
-
-
Lofgren, J.A.1
Wala, I.2
Koren, E.3
Swanson, S.J.4
Jing, S.5
-
28
-
-
34548861488
-
An affinity capture elution (ACE) assay for detection of anti-drug antibody to monoclonal antibody therapeutics in the presence of high levels of drug
-
Bourdage J.S., Cook C.A., Farrington D.L., Chain J.S., and Konrad R.J. An affinity capture elution (ACE) assay for detection of anti-drug antibody to monoclonal antibody therapeutics in the presence of high levels of drug. J Immunol Methods 327 (2007) 10-17
-
(2007)
J Immunol Methods
, vol.327
, pp. 10-17
-
-
Bourdage, J.S.1
Cook, C.A.2
Farrington, D.L.3
Chain, J.S.4
Konrad, R.J.5
-
29
-
-
36048943918
-
Detection of antibodies against therapeutic proteins in the presence of residual therapeutic protein using a solid-phase extraction with acid dissociation (SPEAD) sample treatment prior to ELISA
-
Smith H.W., Butterfield A., and Sun D. Detection of antibodies against therapeutic proteins in the presence of residual therapeutic protein using a solid-phase extraction with acid dissociation (SPEAD) sample treatment prior to ELISA. Regul Toxicol Pharmacol 49 (2007) 230-237
-
(2007)
Regul Toxicol Pharmacol
, vol.49
, pp. 230-237
-
-
Smith, H.W.1
Butterfield, A.2
Sun, D.3
-
30
-
-
41949096282
-
Improvement of drug tolerance in immunogenicity testing by acid treatment on Biacore
-
Sickert D., Kroeger K., Zickler C., Chokote E., Winkler B., Grenet J.M., Legay F., and Zaar A. Improvement of drug tolerance in immunogenicity testing by acid treatment on Biacore. J Immunol Methods 334 (2008) 29-36
-
(2008)
J Immunol Methods
, vol.334
, pp. 29-36
-
-
Sickert, D.1
Kroeger, K.2
Zickler, C.3
Chokote, E.4
Winkler, B.5
Grenet, J.M.6
Legay, F.7
Zaar, A.8
-
31
-
-
33845574138
-
Titration of infliximab treatment in rheumatoid arthritis patients based on response patterns
-
Flendrie M., Creemers M.C., and van Riel P.L. Titration of infliximab treatment in rheumatoid arthritis patients based on response patterns. Rheumatology (Oxford) 46 (2007) 146-149
-
(2007)
Rheumatology (Oxford)
, vol.46
, pp. 146-149
-
-
Flendrie, M.1
Creemers, M.C.2
van Riel, P.L.3
|