The effect of indomethacin on systemic and renal hemodynamics in neonatal piglets during experimental endotoxemia

Pediatric Surgery International

Volumn 24, Issue 8, 2008, Pages 907-911

  Furtado, Nicholas ^a   Beier, Ulf H ^a   Gorla, Sema Rao ^a   Fornell, Linda ^a   Lumpaopong, Adisorn ^a   Radhakrishnan, Jayant ^a   John, Eunice ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Endotoxin; Gram negative sepsis; Indomethacin; Renal function

Indexed keywords

4 AMINOHIPPURIC ACID; ENDOTOXIN; INDOMETACIN; PROSTAGLANDIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL GAS; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFECT; ENDOTOXEMIA; GLOMERULUS FILTRATION RATE; HEART INDEX; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY PERFUSION; KIDNEY VASCULAR RESISTANCE; MEAN ARTERIAL PRESSURE; NEPHROTOXICITY; NEWBORN; NONHUMAN; PIGLET; PRIORITY JOURNAL; SEPSIS; SYSTEMIC CIRCULATION; URINE VOLUME;

ANIMALS; ANIMALS, NEWBORN; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD FLOW VELOCITY; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; ESCHERICHIA COLI INFECTIONS; GLOMERULAR FILTRATION RATE; HEART RATE; INDOMETHACIN; RENAL CIRCULATION; SWINE; TREATMENT OUTCOME;

EID: 48549097668     PISSN: 01790358     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00383-008-2175-z     Document Type: Article

References (17)

1. E Larson JP Cimiotti J Haas M Nesin A Allen P Della-Latta L Saiman 2005 Gram-negative bacilli associated with catheter-associated and non-catheter-associated bloodstream infections and hand carriage by healthcare workers in neonatal intensive care units Pediatr Crit Care Med 6 4 457 461
2. S Heyman D Darmon M Goldfarb H Bitz A Shina S Rosen M Brezis 2000 Endotoxin-induced renal failure. I. A role for altered renal microcirculation Exp Nephrol 8 4-5 266 274
3. F Stapleton DP Jones RS Green 1987 Acute renal failure in neonates: incidence, etiology and outcome Pediatr Nephrol 1 3 314 320
4. J Cohen 2002 The immunopathogenesis of sepsis Nature 420 6917 885 891
5. T van der Poll SJ van Deventer 1999 Cytokines and anticytokines in the pathogenesis of sepsis Infect Dis Clin North Am 13 2 413 426 ix
6. BL Short 1981 Indomethacin improves survival in gram-negative sepsis Adv Shock Res 6 27 36
7. A Azab 2006 Inhibition of prostaglandins does not reduce the cardiovascular changes during endotoxemia in rats Prostaglandins Leukot Essent Fatty Acids 74 2 135 142
8. S Ishise BL Pegram J Yamamoto Y Kitamura ED Frohlich 1980 Reference sample microsphere method: cardiac output and blood flows in conscious rat Am J Physiol 239 4 H443 H449
9. P Gallay 1993 Short time exposure to lipopolysaccharide is sufficient to activate human monocytes J Immunol 150 11 5086 5093
10. C Natanson WD Hoffman AF Suffredini PQ Eichacker RL Danner 1994 Selected treatment strategies for septic shock based on proposed mechanisms of pathogenesis Ann Intern Med 120 9 771 783
11. KJ Peevy 1986 Prostaglandin synthetase inhibition in group B streptococcal shock: hematologic and hemodynamic effects Pediatr Res 20 9 864 866
12. JC Stoclet 1999 Induction of nitric oxide synthase and dual effects of nitric oxide and cyclooxygenase products in regulation of arterial contraction in human septic shock Circulation 100 2 107 112
13. T Yamada 2003 Thromboxane A2 regulates vascular tone via its inhibitory effect on the expression of inducible nitric oxide synthase Circulation 108 19 2381 2386
14. J Osterberg M Ljungdahl U Haglund 2006 Influence of cyclooxygenase inhibitors on gut immune cell distribution and apoptosis rate in experimental sepsis Shock 25 2 147 154
15. JJ Boffa 2004 Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice J Am Soc Nephrol 15 9 2358 2365
16. M Dunn 1987 The role of arachidonic acid metabolites in renal homeostasis. Non-steroidal anti-inflammatory drugs renal function and biochemical, histological and clinical effects and drug interactions Drugs 33 Suppl 1 56 66
17. W Wang 2007 Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice Am J Physiol Renal Physiol 293 4 F1131 F1136