Current concepts in the management of Clostridium tetani infection

Expert Review of Anti-Infective Therapy

Volumn 6, Issue 3, 2008, Pages 327-336

  Brook, Itzhak ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clostridium tetani; Magnesium; Metronidazole; Spasm; Tetanospasmin; Tetanus

Indexed keywords

BACLOFEN; BARBITURIC ACID DERIVATIVE; DIAZEPAM; DOXACURIUM; IMMUNOGLOBULIN; MAGNESIUM SULFATE; METRONIDAZOLE; MORPHINE SULFATE; NEUROMUSCULAR BLOCKING AGENT; PANCURONIUM; PENICILLIN G; PHENOTHIAZINE DERIVATIVE; PLACEBO; PROPOFOL; SUCRALFATE; TETANUS ANTIBODY; TETANUS TOXOID; VECURONIUM; METALLOPROTEINASE; TETANOSPASMIN; TETANUS TOXIN;

ACTIVE IMMUNIZATION; ANTIMICROBIAL THERAPY; ASSISTED VENTILATION; CLINICAL TRIAL; CLOSTRIDIUM TETANI; CONTINUOUS INFUSION; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG INDICATION; DYSAUTONOMIA; GASTROINTESTINAL HEMORRHAGE; HOSPITAL INFECTION; HUMAN; INCIDENCE; INTENSIVE CARE; LACTIC ACIDOSIS; MAINTENANCE DRUG DOSE; MUSCLE RELAXATION; MUSCLE SPASM; MUSCLE STIFFNESS; NEWBORN TETANUS; OPISTHOTONUS; PARENTERAL NUTRITION; PASSIVE IMMUNIZATION; PATHOPHYSIOLOGY; PROGNOSIS; RECOMMENDED DRUG DOSE; REVIEW; RHABDOMYOLYSIS; SEDATION; TETANUS; TETANUS PROPHYLAXIS; TRACHEA STENOSIS; TRACHEOSTOMY; WOUND CARE; ADULT; IMMUNIZATION; IMMUNOLOGY; INFANT; METABOLISM; MICROBIOLOGY; NEWBORN; PATHOGENICITY;

ADULT; CLOSTRIDIUM TETANI; HUMANS; IMMUNIZATION; INFANT; INFANT, NEWBORN; METALLOENDOPEPTIDASES; TETANUS; TETANUS TOXIN; TETANUS TOXOID;

EID: 48449105665     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/14787210.6.3.327     Document Type: Review

References (48)

1. Matzkin H, Regev S. Naturally acquired immunity to tetanus in an isolated community. Infect. Immun. 48, 267-268 (1985).
2. Furste W. Tetanus statistics. JAMA 228, 28 (1974).
3. Bardenheier B, Prevots DR, Khetsuriani N et al. Tetanus surveillance - united states, 1995-1997. MMWR Morb. Mortal. Wkly Rep. 47, 1-13 (1998).
4. Vandelaer J, Birmingham M, Gasse F, Kurian M, Shaw C, Garnier S. Tetanus in developing countries: an update on the Maternal and Neonatal Tetanus Elimination Initiative. Vaccine 21, 3442-3445 (2003).
5. Sanders RK. The management of tetanus 1996. Trop. Doct. 26, 107-115 (1996).
6. Scher KS, Baldera A, Wheeler WE, Walker R, Jones CW. Inadequate tetanus protection among the rural elderly. South Med. J. 78, 153-156 (1985).
7. LaForce FM, Young LS, Bennett JV. Tetanus in the United States (1965-1966): epidemiologic and clinical features. N. Engl. J. Med. 280, 569-574 (1969).
8. Fischer MGW, Sunakorn P, Duangman C. Otogenous tetanus: a sequelae of chronic ear infections. Am. J. Dis. Child. 131, 445-446 (1977).
9. Nourmand A. Clinical studies on tetanus: notes on 42 cures in southern Iran with special emphasis on portal of entry. Clin. Pediatr. 12, 652-653 (1973).
10. Montecucco C, Schiavo G. Mechanism of action of tetanus and botulinum neurotoxins. Mol. Microbiol. 13, 1-8 (1994).
11. Weinstein L. Tetanus. N. Engl. J. Med. 289, 293-296 (1973).
12. Kerr JH, Corbett JL, Prys-Roberts C, Smith AC, Spalding JM. Involvement of the sympathetic nervous system in tetanus: studies on 82 cases. Lancet 2, 236-241 (1968).
13. Turton K, Chaddock JA, Acharya KR. Botulinum and tetanus neurotoxins: structure, function and therapeutic utility. Trends Biochem Sci. 27, 552-558 (2002).
14. Collingridge GL, Davies J. The in vitro inhibition of GABA release by tetanus toxin. Neuropharmacology 21, 851-855 (1982).
15. Farrar JJ, Yen LM, Cook T et al. Tetanus. J. Neurol. Neurosurg. Psychiatry 69, 292-301 (2000).
16. Goulon M, Girard O, Grosbuis S, Desormeau JP, Capponi MF. Antitetanus antibodies. Assay before anatoxinotherapy in 64 tetanus patients. Nouv. Presse Med. 1, 3049-3050 (1972).
17. Henderson DK. Infectious disease emergencies: the clostridial syndromes. West. J. Med. 129, 101-106 (1978).
18. Tseuda K, Oliver PB, Richter RW. Cardio-vascular manifestations of tetanus. Anesthesiology 40, 588-592 (1974).
19. Rose AG. Catecholamine-induced myocardial damage associated with phaeochromocytomas and tetanus. S. Afr. Med. J. 48, 1285-1289 (1974).
20. Hollow VM, Clarke GM. Autonomic manifestations of tetanus. Anaesth. Intensive Care 3, 142-147 (1975).
21. Idema CD, Harris BN, Ogunbanjo GA, Durrheim DN. Neonatal tetanus elimination in Mpumalanga province, South Africa. Trop. Med. Int. Health 7, 622-624 (2002).
22. Ablett JJL. Analysis and main experience in 82 patients treated in the Leeds Tetanus Unit. Symposium on Tetanus in Great Britain. National Lending Library, Boston spa, UK (1967).
23. Yen LM, Dao LM, Day NP et al. Role of quinine in the high mortality of intramuscular injection tetanus. Lancet 17(344), 786-787 (1994).
24. Apte NM, Karnad D. Short report: the spatula test: a simple bedside test to diagnose tetanus. Am. J. Trop. Med. Hyg. 53, 386-387 (1995).
25. Clarke G, Hill RG. Effects of a focal penicillin lesion on responses of rabbit cortical neurones to putative neurotransmitters. Br. J. Pharmacol. 44, 435-441 (1972).
26. Brook I. Presence of β-lactamase-producing bacteria and β-lactamase activity in abscesses. Am. J. Clin. Pathol. 8, 97-101 (1986).
27. Ahmadsyah I, Salim A. Treatment of tetanus: an open study to compare the efficacy of procaine penicillin and metronidazole. Br. Med. J. Clin. Res. Ed. 291, 648-650 (1985).
28. Yen LM, Dao LM, Day NPJ. Management of tetanus: a comparison of penicillin and metronidazole. Presented at: Symposium of Antimicrobial Resistance in Southern Viet Nam. Ho Chi Minh City, Vietnam 1997.
29. Abrutyn E, Berlin JA. Intrathecal therapy in tetanus. A meta-analysis. JAMA 266, 2262-2267 (1991).
30. Kapoor W, Carey P, Karpf M. Induction of lactic acidosis with intravenous diazepam in a patient with tetanus. Arch. Intern. Med. 141, 944-945 (1981).
31. Powles AB, Ganta R. Use of vecuronium in the management of tetanus. Anaesthesia 40, 879-881 (1985).
32. Engrand N, Guerot E, Rouamba A, Vilain G. The efficacy of intrathecal baclofen in severe tetanus. Anesthesiology 90, 1773-1776 (1999).
33. Santos ML, Mota-Miranda A, Alves-Pereira A, Gomes A, Correia J, Marçal N. Intrathecal baclofen for the treatment of tetanus. Clin. Infect. Dis. 38, 321-328 (2004).
34. Engrand N, Vilain G, Rouamba A, Benhamou, D. Value of intrathecal baclofen in the treatment of severe tetanus in the tropical milieu. Med Trop. 60, 385-388 (2000).
35. Buchanan N, Smit L, Cane RD, De Andrade M. Sympathetic over activity in tetanus: fatality associated with propranolol. Br. Med. J. 2, 254-255 (1978).
36. Rocke DA, Wesley AG, Pather M, Calvet AD, Hariparsad D. Morphine in tetanus - the management of sympathetic nervous system overactivity. S. Afr. Med. J. 70, 666-668 (1986).
37. Thwaites CL, Yen LM, Loan HT et al. Magnesium sulphate for treatment of severe tetanus: a randomised controlled trial. Lancet 368, 1436-1443 (2006).
38. Attygalle D, Rodrigo N. Magnesium as first line therapy in the management of tetanus: a prospective study of 40 patients. Anaesthesta 57, 811 (2002).
39. James MF, Manson ED. The use of magnesium sulphate infusions in the management of very severe tetanus. Intensive Care Med. 11, 5-12 (1985).
40. Ceneviva GD, Thomas NJ, Kees-Folts D. Magnesium sulfate fbr control of muscle rigidity and spasms and avoidance of mechanical ventilation in pediatric tetanus. Pediatr. Crit. Care Med. 4, 480-484 (2003).
41. Lipman J, James MF, Erskine J, Plit ML, Eidelman J, Esser JD. Autonomic dysfunction in severe tetanus: magnesium sulfate as an adjunct to deep sedation. Crit. Care Med. 15, 987-988 (1987).
42. Lishajko F. Releasing effect of calcium and phosphate on catecholamines, ATP, and protein from chromaffin cell granules. Acta Physiol. Scand. 79, 575-584 (1970).
43. 2+ on noradrenaline release and uptake in adrenergic nerve granules in differential media. Acta Physiol. Scand. 99, 415-422 (1973).
44. Sun KO, Chan YW, Cheung RT, So PC, Yu YL, Li PC. Management of tetanus: a review of 18 cases. J. R. Soc. Med. 87, 135-137 (1994).
45. Thayaparan B, Nicoll A. Prevention and control of tetanus in childhood. Curr. Opin. Pediatr. 10, 4-8 (1998).
46. American Academy of Pediatrics. Tetanus (lockjaw). In: 2006 Red Book: Report of the Committee on Infectious Diseases (27th Edition). Pickering LK (Ed.). Elk Grove Village, IL, USA 650 (2006).
47. Roper M, Vandelaer J, Gasse F. Maternal and noenatal tetanus. Lancet 370, 1947-1959 (2007).
48. WHO, UNICEF AND UNFPA. Maternal and neonatal tetanus elimination by 2005: strategies for achieving and maintaining elimination. WHO/V&B/ 02.09, WHO, United Nations Childrees Fund, United Nations Population Fund, Geneva, Switzerland (2000).