Poly(Lactic-co-glycolic Acid) nanospheres and microspheres for short- and long-term delivery of bioactive ciliary neurotrophic factor

Biotechnology and Bioengineering

Volumn 100, Issue 5, 2008, Pages 1010-1019

  Nkansah, Michael K ^a   Tzeng, Stephany Y ^a   Holdt, Adam M ^b   Lavik, Erin B ^a  

^a Yale University   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

CNTF; Microspheres; Nanospheres; Neural stem cells; PLGA

Indexed keywords

CENTRAL NERVOUS SYSTEM; CILIARY NEUROTROPHIC FACTOR; CNTF; LOCAL DELIVERY; MATURE CELLS; NEURAL STEM CELLS; NEUROPROTECTION; PLGA; POLY-DL-LACTIC-CO-GLYCOLIC ACID; POLY-LACTIC-CO-GLYCOLIC ACID; PROCESSING VARIABLES; PROTEIN ENCAPSULATION; SIDE EFFECTS; SIMILAR DEGREE; SYSTEMIC ADMINISTRATION;

CELLS; CONCENTRATION (PROCESS); ENCAPSULATION; MICROSPHERES; NANOSPHERES; NANOSTRUCTURED MATERIALS; NANOSTRUCTURES;

NEUROLOGY;

CILIARY NEUROTROPHIC FACTOR; GLYCOLIC ACID DERIVATIVE; MICROSPHERE; NANOSPHERE; LACTIC ACID; NANOMATERIAL; POLYGLYCOLIC ACID; POLYLACTIC ACID POLYGLYCOLIC ACID COPOLYMER; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; ASTROCYTE; CELL MATURATION; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG RELEASE; ENCAPSULATION; HUMAN; HUMAN CELL; NEURAL STEM CELL; OLIGODENDROGLIA; CELL CULTURE; CELL DIFFERENTIATION; CHEMISTRY; CYTOLOGY; DELAYED RELEASE FORMULATION; DRUG EFFECT; MATERIALS TESTING; MICROCAPSULE; NERVE CELL; PARTICLE SIZE; STEM CELL; ULTRASTRUCTURE;

CAPSULES; CELL DIFFERENTIATION; CELLS, CULTURED; CILIARY NEUROTROPHIC FACTOR; DELAYED-ACTION PREPARATIONS; HUMANS; LACTIC ACID; MATERIALS TESTING; NANOSTRUCTURES; NEURONS; PARTICLE SIZE; POLYGLYCOLIC ACID; STEM CELLS;

EID: 48449094740     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.21822     Document Type: Article

References (52)

1. Aebischer P, Schluep M, Deglon N, Joseph JM, Hirt L, Heyd B, Goddard M, Hammang JP, Zurn AD, Kato AC, Regli F, Baetge EE. 1996. Intrathecal delivery of CNTF using encapsulated genetically modified xenogeneic cells in amyotrophic lateral sclerosis patients. Nat Med 2(6):696-699.
2. ALS CNTF Treatment Study Group. 1996. A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group. Neurology 46(5):1244-1249.
3. Athanasiou KA, Niederauer GG, Agrawal CM. 1996. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polygly-colic acid copolymers. Biomaterials 17(2):93-102.
4. Bae YH, Mikos AG. 2000. Cells for drug delivery platforms. Adv Drug Deliv Rev 42(l-2):l-2.
5. Berkland C, Pollauf E, Raman C, Silverman R, Kim K, Pack DW. 2007. Macromolecule release from monodisperse PLG microspheres: Control of release rates and investigation of release mechanism. J Pharm Sci 96(5):1176-1191.
6. Bilati U, Allemann E, Doelker E. 2005. Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and micro-particles. Eur J Pharm Biopharm 59(3):375-388.
7. Bodmer D, Kissel T, Traechslin E. 1992. Factors influencing the release of peptides and proteins from biodegradable parenteral depot systems. J Control Release 21(1-3):129-138.
8. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME. 1997. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science 278(5337):477-483.
9. Burdick JA, Ward M, Liang E, Young MJ, Langer R. 2006. Stimulation of neurite outgrowth by neurotrophins delivered from degradable hydrogels. Biomaterials 27(3):452-459.
10. Chung HJ, Kim HK, Yoon JJ, Park TG. 2006a. Heparin immobilized porous PLGA microspheres for angiogenic growth factor delivery. Pharm Res 23(8):1835-1841.
11. Chung TW, Tsai YL, Hsieh JH, Tsai WJ. 2006b. Different ratios of lactide and glycolide in PLGA affect the surface property and protein delivery characteristics of the PLGA microspheres with hydrophobic additives. J Microencapsul 23(1):15-27.
12. Clatterbuck RE. 1993. Cliliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system. Proc Natl Acad Sci USA 90:2222-2226.
13. Dittrich F, Thoenen H, Sendtner M. 1994. Ciliary neurotrophic factor: Pharmacokinetics and acute-phase response in rat. Ann Neurol 35(2): 151-163.
14. Edlund U, Albertsson AC. 2001. Degradable polymer microspheres for controlled drug delivery. Degrad Aliphat Polyesters 157:67-112.
15. Emerich DF, Winn SR, Hantraye PM, Peschanski M, Chen EY, Chu Y, McDermott P, Baetge EE, Kordower JH. 1997. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature 386(6623):395-399.
16. Fu K, Harrell R, Zinski K, Urn C, Jaklenec A, Frazier J, Lotan N, Burke P, Klibanov AM, Langer R. 2003. A potential approach for decreasing the burst effect of protein from PLGA microspheres. J Pharm Sci 92(8): 1582-1591.
17. Griebenow K, Klibanov AM. 1996. On protein denaturation in aqueous-organic mixtures but not in pure organic solvents. J Am Chem Soc 118(47):11695-11700.
18. Hagg T, Varon S. 1993. Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc Natl Acad Sci USA 90(13):6315-6319.
19. Hora MS, Rana RK, Nunberg JH, Tice TR, Gilley RM, Hudson ME. 1990. Release of human serum albumin from polylactide-co-glycolide microspheres. Pharm Res 7:1190-1194.
20. Jaraswekin S, Prakongpan S, Bodmeier R. 2007. Effect of poly(lactide-co-glycolide) molecular weight on the release of dexamethasone sodium phosphate from microparticles. J Microencapsul 24(2): 117-128.
21. Jeon O, Kang SW, Lim HW, Hyung Chung J, Kim BS. 2006. Long-term and zero-order release of basic fibroblast growth factor from heparin-conjugated poly(L-lactide-co-glycolide) nanospheres and fibrin gel. Biomaterials 27(8):1598-1607.
22. Johe KK, Hazel TG, Muller T, Dugich-Djordjevic MM, McKay RD. 1996. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system. Genes Dev 10(24):3129-3140.
23. Kang SW, Jeon O, Kim BS. 2005. Poly(lactic-co-glycolic acid) microspheres as an injectable scaffold for cartilage tissue engineering. Tissue Eng 11(3-4):438-447.
24. Lachyankar MB, Condon PJ, Quesenberry PJ, Litofsky NS, Recht LD, Ross AH. 1997. Embryonic precursor cells that express Trk receptors: Induction of different cell fates by NGF, BDNF, NT-3, and CNTF. Exp Neurol 144(2);350-360.
25. Lecaroz C, Gamazo C, Renedo MJ, Blanco-Prieto MJ. 2006. Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin. J Microencapsul 23(7):782-792.
26. Lee JE, Kim KE, Kwon IC, Ahn HJ, Lee SH, Cho H, Kim HJ, Seong SC, Lee MC. 2004. Effects of the controlled-released TGF-beta 1 from chitosan microspheres on chondrocytes cultured in a collagen/chitosan/glyco-saminoglycan scaffold. Biomaterials 25(18):4163-4173.
27. Maysinger D, Krieglstein K, Filipovic-Grcic J, Sendtner M, Unsicker K, Richardson P. 1996. Microencapsulated ciliary neurotrophic factor: Physical properties and biological activities. Exp Neurol 138(2):177-188.
28. Mehta RC, Thanoo BC, DeLuca PP. 1996. Peptide containing microspheres from low molecular weight and hydrophilic poly(D,r-lactide-a)-glycolide). J Control Release 41:249-257.
29. Moioli EK, Hong L, Guardado J, Clark PA, Mao JJ. 2006. Sustained release of TGFbeta3 from PLGA microspheres and its effect on early osteogenic differentiation of human mesenchymal stem cells. Tissue Eng 12(3): 537-546.
30. Niwa T, Takeuchi H, Hino T, Kunou N, Kawashima Y. 1993. Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with -lactide/glycolide copolymer by a novel spontaneous emulsifica-tion solvent diffusion method, and the drug release behavior. J Control Release 25(l-2):89-98.
31. Oldham JB, Lu L, Zhu X, Porter BD, Hefferan TE, Larson DR, Currier BL, Mikos AG, Yaszemski MJ. 2000. Biological activity of rhBMP-2 released from PLGA microspheres. J Biomech Eng 122(3):289-292.
32. Peltonen L, Koistinen P, Karjalainen M, Hakkinen A, Hirvonen J. 2002. The effect of cosolvents on the formulation of nanoparticles from low-molecular-weight poly(1)lactide. AAPS PharmSciTech 3(4):E32.
33. Perets A, Baruch Y, Weisbuch F, Shoshany G, Neufeld G, Cohen S. 2003. Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J Biomed Mater Res A 65(4):489-497.
34. Perez C, Castellanos IJ, Costantino HR, Al-Azzam W, Griebenow K. 2002. Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers. J Pharm Pharmacol 54(3):301-313.
35. Rajan P, McKay RD. 1998. Multiple routes to astrocytic differentiation in the CNS. J Neurosci 18(10):3620-3629.
36. Ravivarapu HB, Burton K, DeLuca PP. 2000. Polymer and microsphere blending to alter the release of a peptide from PLGA microspheres. Eur J Pharm Biopharm 50(2):263-270.
37. Richardson TP, Peters MC, Ennett AB, Mooney DJ. 2001. Polymeric system for dual growth factor delivery. Nat Biotechnol 19(11):1029-1034.
38. Sendtner M, Schmalbruch H, Stockli KA, Carroll P, Kreutzberg GW, Thoenen H. 1992. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358(6386):502-504.
39. Sendtner M, Carroll P, Holtmann B, Hughes RA, Thoenen H. 1994. Ciliary neurotrophic factor. J Neurobiol 25(11): 1436-1453.
40. Shatos MA, Mizumoto K, Mizumoto H, Kurimoto Y, Klassen H, Young MJ. 2001. Multipotent stem cells from the brain and retina of green mice. E-Biomed J Regen Med 2(3):13-15.
41. Stankoff B, Aigrot MS, Noel F, Wattilliaux A, Zalc B, Lubetzki C. 2002. Ciliary neurotrophic factor (CNTF) enhances myelin formation: A novel role for CNTF and CNTF-related molecules. J Neurosci 22(21): 9221-9227.
42. Tabata Y, Gutta S, Langer R. 1993. Controlled delivery systems for proteins using polyanhydride microspheres. Pharm Res 10(4):487-496.
43. Tan SA, Deglon N, Zurn AD, Baetge EE, Bamber B, Kato AC, Aebischer P. 1996. Rescue of motoneurons from axotomy-induced cell death by polymer encapsulated cells genetically engineered to release CNTF. Cell Transplant 5(5):577-587.
44. Tao W, Wen R, Goddard MB, Sherman SD, O'Rourke PJ, Stabila PF, Bell WJ, Dean BJ, Kauper KA, Budz VA. et al. 2002. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 43(10): 3292-3298.
45. Thomson R, Wake M, Yaszemski M, Mikos A. 1995. Biodegradable polymer scaffolds to regenerate organs. Biopolymers II 122:245-274.
46. Tracy MA, Ward KL, Firouzabadian L, Wang Y, Dong N, Qian R, Zhang Y. 1999. Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro. Biomaterials 20(11): 1057-1062.
47. Tresco PA, Biran R, Noble MD. 2000. Cellular transplants as sources for therapeutic agents. Adv Drug Deliv Rev 42(l-2):3-27.
48. van de Weert M, Hennink WE, Jiskoot W. 2000. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm Res 17( 10):1159-1167.
49. Visscher GE, Robison RL, Maulding HV, Fong JW, Pearson JE, Argentieri GJ. 1986. Biodegradation of and tissue reaction to poly(DL-lactide) microcapsules. J Biomed Mater Res 20(5):667-676.
50. Vivek Ranjan S, Ashu A, Aman T. 2004. Biodegradable PEGylated Microspheres and Nanospheres. Am J Drug Delivery 2:157-171.
51. Yoo JY, Kim JM, Seo KS, Jeong YK, Lee HB, Khang G. 2005. Characterization of degradation behavior for PLGA in various pH condition by simple liquid chromatography method. Biomed Mater Eng 15(4):279-288.
52. Zhang JX, Zhu KJ, Chen D. 2005. Preparation of bovine serum albumin loaded poly (D, L-lactic-co-glycolic acid) microspheres by a modified phase separation technique. J Microencapsul 22(2):117-126.