Protective effect of liposome-mediated glial cell line-derived neurotrophic factor gene transfer in vivo on motoneurons following spinal cord injury in rats

Chinese Journal of Traumatology - English Edition

Volumn 7, Issue 5, 2004, Pages 275-279

  Lu, Kai Wu ^a   Chen, Zhe Yu ^a   Hou, Tie Sheng ^a  

^a FIRST MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Gene therapy; Liposome; Motor neurons; Spinal cord injury

Indexed keywords

ACID PHOSPHATASE; CHOLINESTERASE; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; LIPOSOME; NEUROTROPHIC FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR HORN CELL; ARTICLE; CELL COUNT; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; FUNCTIONAL ASSESSMENT; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE TRANSFER; GLIA CELL; HINDLIMB; HISTOCHEMISTRY; IN VIVO STUDY; LOCOMOTION; MALE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPROTECTION; NISSL STAINING; NONHUMAN; RAT; RATING SCALE; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD INJURY; SPINAL CORD MOTONEURON;

EID: 4844226749     PISSN: 10081275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Tuszynski MH, Peterson DA, Ray J, et al . Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp Neurol 1994;126:1-14
2. Henderson CE, Phillips HS, Pollock RA, et al. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 1994;266:1062-1064.
3. Yang K, Clifton GL, Hayes RL. Gene therapy for central nervous injury: the use of cationic liposomes: an invited review. J Neurotrauma 1997;14:281-297.
4. Nystrom B, Berglund JE, Bergquist E. Methodological analysis of an experimental spinal cord compression model in the rat. Acta Neurol Scand 1988;78:460-466.
5. Basso DM, Beattie MS, Bresnahan JC, et al. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. J Neurotrauma 1996;13:343-359.
6. Lin LF, Doherty DH, Lile JD, et al. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 1993;260:1130-1132.
7. Cheng H, Wu JP, Tzeng SF. Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury. J Neurosci Res 2002;69:397-405.
8. Watabe K, Ohashi T, Sakamoto T, et al. Rescue of lesioned adult rat spinal moloneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor. J Neuro Sci Res 2000;60:511-519.
9. Iannotti C, Li H, Yan P, et al. Glial cell line-derived neurotrophic factor-enriched bridging transplants promote propriospinal axonal regeneration and enhance myelination after spinal cord injury. Exp Neurol 2003;183:379-393.
10. Dolbeare D, Houle JD. Restriction of axonal retraction and promotion of axonal regeneration by chronically injured neurons after intraspinal treatment with glial cell line-derived neurotrophic factor (GDNF). J Neurotrauma 2003;20:1251-1261.
11. Yang K, Mu XS, Hayes RL, et al. DC-Chol liposome-mediated gene transfer in rat spinal cord. Neuroreport 1997;8: 2355-2358.