Review article: Treatment of perianal fistulizing Crohn's disease

Alimentary Pharmacology and Therapeutics, Supplement

Volumn 20, Issue 4, 2004, Pages 106-110

  Rutgeerts, P ^a,b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; AZATHIOPRINE; BECLOMETASONE DIPROPIONATE; CIPROFLOXACIN; CYCLOSPORIN; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METRONIDAZOLE; SALAZOSULFAPYRIDINE; TACROLIMUS;

ABSCESS DRAINAGE; ANTIBIOTIC THERAPY; ANUS FISTULA; CLINICAL PROTOCOL; CLINICAL TRIAL; CROHN DISEASE; DISEASE ACTIVITY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; ENDOSCOPIC ECHOGRAPHY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION CONTROL; MAINTENANCE THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; PERIANAL FISTULIZING CROHN DISEASE; PRIORITY JOURNAL; PROGNOSIS; RECTUM RESECTION; REVIEW; SEPSIS; SHORT COURSE THERAPY; SKIN FISTULA;

ALGORITHMS; ANTI-BACTERIAL AGENTS; ANUS DISEASES; CROHN DISEASE; GASTROINTESTINAL AGENTS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PROGNOSIS; RECTAL FISTULA;

EID: 4844225774     PISSN: 09530673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (23)

1. Crohn BB, Ginzburg L, Oppenheimer GD. Regional ileitis; a pathologic and clinical entity. J Am Med Assoc 1932; 99: 1323-9.
2. Bissell AD. Localized chronic ulcerative ileitis. Ann Surg 1934; 99: 957-66.
3. Morson BC, Lockhart-Mummery HE. Anal lesions in Crohn's disease. Lancet 1959; 2: 1122-3.
4. Lockhart-Mummery HE, Morson BC. Crohn's disease of the large intestine. Gut 1964; 5: 493-509.
5. Gray BK, Lockhart-Mummery HE, Morson BC. Crohn's disease of the anal region. Gut 1965; 6: 515-24.
6. Hughes LE, Taylor BA. Perianal lesions in Crohn's disease. In: Allan RN, Keighley MRB, Alexander-Williams J, Hawkins C, eds. Inflammatory Bowel Diseases. New York: Churchill Livingstone, 1990: 351-61.
7. Hellers G, Bergstrand O, Ewerth S, Holmstrom B. Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease. Gut 1980; 21: 525-7.
8. Cohen Z. An approach to perirectal disease in inflammatory bowel disease. Inflamm Bowel Dis 1999; 5: 228-30.
9. Borley NR, Mortensen NJ, Jewell DP. MRI scanning in perianal Crohn's disease: an important diagnostic adjunct. Inflamm Bowel Dis 1999; 5: 231-3.
10. Hughes LE, Donaldson DR, Williams JG, Taylor BA, Young HL. Local depot methylprednisolone injection for painful anal Crohn's disease. Gastroenterology 1988; 94: 709-11.
11. Bernstein LH, Frank MS, Brandt LJ, Boley SJ. Healing of perineal Crohn's disease with metronidazole. Gastroenterology 1980; 79: 357-65.
12. Brandt LJ, Bernstein LH, Boley SJ, Frank MS. Metronidazole therapy for perineal Crohn's disease: a follow-up study. Gastroenterology 1982; 83: 383-7.
13. Jakobovits J, Schuster MM. Metronidazole therapy for Crohn's disease and associated fistulae. Am J Gastroenterol 1984; 79: 533-40.
14. Solomon MJ, McLeod RS, O'Connor BI, Steinhart AH, Greenberg GR, Cohen Z. Combination ciprofloxacin and metronidazole in severe perianal Crohn's disease. Can J Gastroenterol 1993; 7: 571-3.
15. Hanauer SB, Smith MB. Rapid closure of Crohn's disease fistulas with continuous intravenous cyclosporin A. Am J Gastroenterol 1993; 88: 646-9.
16. Present DH, Lichtiger S. Efficacy of cyclosporine in treatment of fistula of Crohn's disease. Dig Dis Sci 1994; 39: 374-80.
17. Egan LJ, Sandborn W, Tremaine WJ. Clinical outcome following treatment of refractory inflammatory and fistulizing Crohn's disease with intravenous cyclosporine. Am J Gastroenterol 1998; 93: 442-8.
18. Markowitz J. Cyclosporin lacks therapeutic efficacy in highly destructive perianal disease associated with Crohn's disease. Am J Gastroenterol 1993: 88: 1620-4.
19. Sandborn WJ, Present DH, Isaacs KL, et al. Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized placebo-controlled trial. Gastroenterology 2003; 125: 380-8.
20. Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 1980; 302: 981-7.
21. O'Brien JJ, Bayless TM, Bayless JA. Use of azathioprine or 6-mercaptopurine in the treatment of Crohn's disease. Gastroenterology 1991; 101(1): 39-46.
22. Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340: 1398-405.
23. Sands B, van Deventer S, Bernstein C, et al. Long-term treatment of fistulizing Crohn's disease: response to infliximab in the Accent II trial through 54 weeks. Gastroenterology 2002; 122: A81.