A comparison between in vitro rat and human and in vivo rat skin absorption studies

Human and Experimental Toxicology

Volumn 23, Issue 9, 2004, Pages 421-430

  van Ravenzwaay, Bennard ^a   Leibold, E ^a  

^a BASF SE   (Germany)

Author keywords

Absorption; Human; In vitro; In vivo; Rat; Skin

Indexed keywords

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; EXPOSURE; FREQUENCY ANALYSIS; HUMAN; HUMAN TISSUE; HYDROPHILICITY; IN VITRO STUDY; IN VIVO STUDY; INTERMETHOD COMPARISON; LIPOPHILICITY; MATHEMATICAL COMPUTING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; SKIN ABSORPTION; SKIN PENETRATION; SKIN PERMEABILITY; SKIN TOXICITY; SPECIES DIFFERENCE; STATISTICAL SIGNIFICANCE; TOXICITY TESTING;

ANIMALS; DERMIS; EPIDERMIS; HUMANS; HYDROPHOBICITY; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RATS; RISK ASSESSMENT; SKIN; SKIN ABSORPTION;

EID: 4844223252     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327104ht471oa     Document Type: Article

References (18)

1. Dugard PH, Scott RC. Absorption through skin. In Baden HP ed. Chemotherapy of psoriasis. Oxford: Pergamon Press, 1984: 125-44.
2. Dugard PH, Walker M, Mawdsley SJ, Scott RC. Absorption of some glycol ethers through human skin in vitro. Env Health Persp 1984; 57: 193-97.
3. ECETOC. Percutaneous absorption. Monograph No. 20 1993; Brussels, Belgium.
4. Steiling W, Kreutz J, Hofer H. Percutaneous penetration/dermal absorption of hair dyes in vitro. Toxicol In Vitro 2001; 15: 565-70.
5. OECD. Test guideline no. 427, Skin absorption: in vivo method. Paris: Organisation for Economic Co-operation and Development, 2003.
6. OECD. Test guideline no. 428, Skin absorption: in vitro method. Paris: Organisation for Economic Co-operation and Development, 2003.
7. Scott RC, Batten PL, Clowes HM, Jones BK, Ramsey JD. Further validation of an in vitro method to reduce the need for in vivo studies for measuring the absorption of chemicals through rat skin. Fundam Appl Toxicol 1992; 19: 484-92.
8. Scott RC, Carmichael NG, Huckles KR, Needham D, Savage T. Methods for measuring dermal penetration of pesticides. Food Chem Toxicol 1993; 31: 523-29.
9. Diembeck W, Beck H, Benech-Kieffer F, Courtelle-month P, Dupuis J, Lovell W, Paye M, Spengler J, Steiling W. Test guidelines for in vitro assessment of dermal absorption and percutaneous penetration of cosmetic ingredients. Food Chem Toxicol 1999; 37: 191-205.
10. Franz T. Percutaneous absorption. On the relevance of in vitro data. J Invest Dermatol 1975; 64: 190-95.
11. OECD. Principles of good laboratory practice. Paris: Organisation for Economic Co-operation and Development, 1981.
12. Hotchkiss SAM, Hewitt P, Caldwell J. Percutaneous absorption of nicotinic acid, phenol, benzoic acid and triclopyr butoxyethyl ester through rat and human skin in vitro: further validation of an in vitro model by comparison with in vivo data. Food Chem Toxicol 1992; 30: 891-99.
13. Kemppainen BW, Reifenrath WG, Stafford RG, Mehta M. Methods for in vitro skin absorption studies of a lipophilic toxin produced by red tide. Toxicology 1991; 66: 1-17.
14. Ross JH, Dong MH, Krieger MI. Conservatism in pesticide exposure assessment. Regul Toxicol Pharmacol 2000; 31: 53-58.
15. van de Sandt JJM, Meuling WJA, Elliott GR, Cnubben NHP, Hakkert BC, Comparative in vitro-in vivo percutaneous absorption of the pesticide propoxur. Toxicol Sci 2000; 58: 15-22.
16. United States Environmental Protection Agency. Heath effects guideline OPPTS 870.7600 Dermal penetration. Washington, DC: USEPA, 1998.
17. European Union, Scientific Committee on Cosmetic Products and Non-Food Products. Opinion concerning basic criteria for the in vitro assessment of dermal absorption of cosmetic ingredients, October 2003, SCCNFP/075/03.
18. Ramsey JD, Woollen BH, Auton TR, Scott RC. The predictive accuracy of in vitro measurements for the dermal absorption of a lipophilic penetrant (fluazifopbutyl) through rat and human skin. Fundam Appl Toxicol 1994; 23: 230-36.