Epigenetic epidemiology of obesity: Application of epigenomic technology

Nutrition Reviews

Volumn 66, Issue SUPPL.1, 2008, Pages

  Waterland, Robert A ^a  

^a CHILDREN S NUTRITION RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; GENE CONTROL; GENE EXPRESSION; GENE MAPPING; GENE MUTATION; GENETIC VARIABILITY; GENOME IMPRINTING; HUMAN; MICROARRAY ANALYSIS; NONHUMAN; OBESITY; PREVALENCE; RISK ASSESSMENT;

ANIMALS; ENVIRONMENT; EPIGENESIS, GENETIC; FEMALE; HUMANS; HYPOTHALAMUS; LACTATION; OBESITY; PREGNANCY; PREGNANCY COMPLICATIONS;

EID: 48349134698     PISSN: 00296643     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2008.00060.x     Document Type: Conference Paper

References (12)

1. Waterland RA, Garza C. Potential mechanisms of metabolic imprinting that lead to chronic disease. Am J Clin Nutr. 1999 69 : 179 197.
2. Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet. 2003 33 (Suppl S245 S254.
3. Waterland RA, Jirtle RL. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition. 2004 20 : 63 68.
4. Waterland RA. Does nutrition during infancy and early childhood contribute to later obesity via metabolic imprinting of epigenetic gene regulatory mechanisms? In : Hernell O Schmitz J, ed. Feeding During Late Infancy and Early Childhood: Impact on Health. Vevey : Nestec 2005 : 157 174.
5. Levin BE. The obesity epidemic: metabolic imprinting on genetically susceptible neural circuits. Obes Res. 2000 8 : 342 347.
6. Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science. 2004 304 : 108 110.
7. Rankinen T, Zuberi A, Chagnon YC, et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring). 2006 14 : 529 644.
8. Melzner I, Scott V, Dorsch K, et al. Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. J Biol Chem. 2002 277 : 45420 45427.
9. Newell-Price J, King P, Clark AJ. The CpG island promoter of the human proopiomelanocortin gene is methylated in nonexpressing normal tissue and tumors and represses expression. Mol Endocrinol. 2001 15 : 338 348.
10. Waterland RA, Michels KB. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr. 2007 27 : 363 388.
11. Shen L, Kondo Y, Guo Y, et al. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genet. 2007 3 : 2023 2036.
12. Shen L, Guo Y, Chen X, Ahmed S, Issa JP. Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis. Biotechniques. 2007 42 : 48, 50, 52 passim.