Label-free differential leukocyte counts using a microfabricated, single-cell impedance spectrometer

Proceedings of IEEE Sensors

Volumn , Issue , 2007, Pages 1452-1455

  Holmes, David ^a   Sun, Tao ^a   Morgan, Hywel ^a   Holloway, Judith ^a   Cakebread, Julie ^a   Davies, Donna ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MATERIALS; BLOOD; CELL CULTURE; CHEMICAL SENSORS; CYTOLOGY; ELECTRIC IMPEDANCE; ELECTRIC NETWORK ANALYSIS; ELECTRIC PROPERTIES; FLUORESCENCE; INTEGRATED CIRCUITS; MATERIALS PROPERTIES; NANOFLUIDICS; POPULATION STATISTICS; SENSORS;

BIOLOGICAL CELLS; BLOOD CELLS; CELL IMPEDANCE; CELL SORTING; CELL SUSPENSIONS; ELECTRICAL PROPERTIES; FLOW-THROUGH; FLUORESCENCE ANALYSIS; HIGH SPEEDS; HUMAN BLOODS; IMPEDANCE ANALYSIS; IMPEDANCE MEASUREMENTS; IMPEDANCE PROPERTIES; IMPEDANCE SPECTROSCOPIES; LABEL-FREE; MICRO-FLUIDIC DEVICES; NON-INVASIVE; SINGLE CELLS; SPECIFIC FREQUENCIES; SUB-POPULATIONS;

CELLS;

EID: 48349115887     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ICSENS.2007.4388687     Document Type: Conference Paper

References (14)

1. H. Morgan and N. G. Green, AC Elelectrokinetics: colloid and nanoparticles, Research Studies Press, England, 2003.
2. H. E. Ayliffe, A. B. Frazier and R. D. Rabbit Noble, "Electric impedance spectroscopy using microchannel with integrated electrodes," IEEE Microelectromechan, Sys., vol.8, pp. 50-57, 1999.
3. S. Gawad, L. Schild and Ph. Renaud, "Micromachined impedance spectroscopy flow cytometer for cell analysis and particle sizing," Lab Chip, vol.1, pp.76-82, 2001.
4. D. Holmes, M. E. Sandison, N. G. Green, and H. Morgan, "On-chip high-speed sorting of micron-sized particles for high-throughput analysis," IEE Proc. Nanobiotechnology, vol.152, pp.129-135, 2005.
5. H. Morgan, D. Holmes, and N.G. Green, " High speed simultaneous single particle impedance and fluorescence analysis on a chip," Cur. Appl. Phys. vol.6, pp.367-370, 2006.
6. H. Morgan, T. Sun, D. Holmes, S. Gawad and N. G. Green, "Single cell dielectric spectroscopy," J. Phy. D: Appl. Phys, vol.40, pp.61-70, 2007.
7. J. Clerk Maxwell, A Treatise on Electricity and Magnetism, New York: Dover, 1935.
8. K. R. Foster and H. P. Schwan, "Dielectric properties of tissues and biological materials: A critical review," Crit. Rev. Biomed. Eng., vol.17, pp.25-104, 1989.
9. J. O' M. Bockris and A. K. N. Reddy, Modern Electrochemistry, Plenum Press, New York, 1973.
10. H. P. Schwan, " Electrical properties of tissue and cell suspensions," Adv. Biol. Med. Phys., vol. 5, pp. 147-209, 1957.
11. H. Pauly and H. P.Schwan, "Uber die Impedanz einer Suspension von kugelformigen Teilchen mit einer Schale," Z.Naturforsch, vol.14B, pp.125-132, 1959.
12. T. Sun, S. Gawad, N. G. Green and H. Morgan, "Dielectric spectroscopy of single cells: time domain analysis using Maxwell's mixture equation," J. Phys. D: Appl. Phys., vol. 40, pp.1-8, 2007.
13. D. Holmes, H. Morgan, N. G. Green, "High throughput particle analysis: combining dielectrophoretic particle focussing with confocal optical detection," Biosensors and Bioelectronics, vol.21, pp.1621-1630, 2006.
14. D. Holmes, J. K. She, P. L. Roach and H. Morgan, "Bead-based immunoassays using a micro-chip flow cytometer," Lab Chip, vol.7, pp.1048-1056, 2007.