Hemodiafiltration and high-flux hemodialysis significantly reduce serum valproate levels inducing epileptic seizures: Case report

Blood Purification

Volumn 26, Issue 4, 2008, Pages 379-380

  Gubensek, Jakob ^a   Buturovic Ponikvar, Jadranka ^a   Ponikvar, Rafael ^a   Cebular, Bostjan ^a  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

Author keywords

[No Author keywords available]

Indexed keywords

ETIRACETAM; KEPRA; PERFLUOROBUTYLTETRAHYDROFURAN; UNCLASSIFIED DRUG; VALPROIC ACID;

ADULT; ANTICONVULSANT THERAPY; ARTIFICIAL KIDNEY; CASE REPORT; COMPLEX PARTIAL SEIZURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EPILEPSY; FEMALE; FOCAL GLOMERULOSCLEROSIS; HEMODIAFILTRATION; HEMODIALYSIS; HUMAN; LETTER; PRIORITY JOURNAL; TREATMENT OUTCOME;

ADULT; EPILEPSY; FEMALE; HEMODIAFILTRATION; HUMANS; PIRACETAM; RENAL DIALYSIS; VALPROIC ACID;

EID: 48349105862     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000135677     Document Type: Letter

References (7)

1. Israni RK, Kasbekar N, Haynes K, Berns JS: Use of antiepileptic drugs in patients with kidney disease. Semin Dial 2006;19:408-416.
2. Marbury TC, Lee CS, Bruni J, Wilder BJ: Hemodialysis of valproic acid in uremic patients. Dial Transplant 1980;9:961-964.
3. Kandrotas RJ, Love JM, Gal P, Oles KS: The effect of hemodialysis and hemoperfusion on serum valproic acid concentration. Neurology 1990;40:1456-1458.
4. Kane SL, Constantiner M, Staubus AE, Meinecke CD, Sedor JR: High-flux hemodialysis without hemoperfusion is effective in acute valproic acid overdose. Ann Pharmacother 2000;34:1146-1151.
5. Hicks LK, McFarlane PA: Valproic acid overdose and haemodialysis. Nephrol Dial Transplant 2001;16:1483-1486.
6. Zaccara G, Messori A, Moroni F: Clinical pharmacokinetics of valproic acid - 1988. Clin Pharmacokinet 1988;15:367-389.
7. Bruni J, Wang LH, Marbury TC, Lee CS, Wilder BJ: Protein binding of valproic acid in uremic patients. Neurology 1980;30:557-559.