Stability in urine of authentic phenylglyoxylic and mandelic acids as urinary markers of occupational exposure to styrene

Journal of Occupational Health

Volumn 50, Issue 3, 2008, Pages 221-228

  Eitaki, Yoko ^a   Kawai, Toshio ^a   Kishi, Reiko ^b   Sakurai, Haruhiko ^a   Ikeda, Masayuki ^c  

^a JAPAN INDUSTRIAL SAFETY AND HEALTH ASSOCIATION   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYOTO INDUSTRIAL HEALTH ASSOCIATION   (Japan)

Author keywords

Mandelic acid; PH; Phenylgyoxylic acid; Stability; Urine

Indexed keywords

BIOLOGICAL MARKER; GLYOXYLIC ACID DERIVATIVE; MANDELIC ACID; MANDELIC ACID DERIVATIVE; PHENYLGLYOXYLIC ACID; STYRENE;

ADULT; ARTICLE; CHEMICAL INDUSTRY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LABORATORY DIAGNOSIS; MALE; METHODOLOGY; MIDDLE AGED; OCCUPATIONAL EXPOSURE; PH; REPRODUCIBILITY; TEMPERATURE; TIME; URINE;

ADULT; BIOLOGICAL MARKERS; CHEMICAL INDUSTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; GLYOXYLATES; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MANDELIC ACIDS; MIDDLE AGED; OCCUPATIONAL EXPOSURE; REPRODUCIBILITY OF RESULTS; SPECIMEN HANDLING; STYRENE; TEMPERATURE; TIME FACTORS;

EID: 48249145738     PISSN: 13419145     EISSN: 13489585     Source Type: Journal    
DOI: 10.1539/joh.L7133     Document Type: Article

References (25)

1. Ikeda M, Imamura T, Hayashi M, Tabuchi T and Hara I: Evaluation of hippuric, phenylglyoxylic and mandelic acids in urine as indices of styrene exposure. Int Arch Arbeitsmed 32, 93-101 (1974)
2. Samoto H, Fukui Y, Ukai H, Okamoto S, Takada S, Ohashi F, Moriguchi J, Ezaki T and Ikeda M: Field survey on types of organic solvents used in enterprises of various sizes. Int Arch Occup Environ Health 79, 558-567 (2006)
3. Ikeda M, Koizumi A, Miyasaka M and Watanabe T: Styrene exposure and biologic monitoring in FRP boat production plants. Int Arch Occup Environ Health 49, 325-339 (1982)
4. Watanabe T, Endo A, Sato K, Ohtsuki T, Miyasaka M, Koizumi A and Ikeda M: Mutagenic potential of styrene in man. Ind Health 19, 37-45 (1981)
5. Watanabe T, Endo A, Kumai M and Ikeda M: Chromosome aberrations and sister chromatid exchanges in styrene-exposed workers with reference to their smoking habits. Environ Mutagenesis 5, 299-309 (1983)
6. Kawai T, Yasugi T, Mizunuma K, Horiguchi S, Morioka I, Miyashita K, Uchida Y and Ikeda M: Monitoring of workers exposed to a mixture of toluene, styrene and methanol vapours by means of diffusive air sampling, blood analysis and urinalysis. Int Arch Occup Environ Health 63, 429-435 (1992)
7. Kawai T, Mizunuma K, Yasugi T, Horiguchi S and Ikeda M: Effective prevention of styrene monomer exposure by protective respirators in fiber-reinforced plastics work. Occup Hyg 1, 153-161 (1994)
8. Kawai T, Mizunuma K, Yasugi T, Horiguchi S, Moon C-S, Zhang Z-W, Miyashita K, Takeda S and Ikeda M: Effects of methanol on styrene metabolism among workers occupationally exposed at low concentrations. Arch Environ Contam Toxicol 28, 543-546 (1995)
9. Mizunuma K, Yasugi T, Kawai T, Horiguchi S and Ikeda M: Exposure-excretion relationship of styrene and acetone in factory workers: a comparison of a lipophilic solvent and a hydrophilic solvent. Arch Environ Contam Toxicol 25, 129-133 (1993)
10. Ong CN, Shi CY, Chia SE, Chua SC, Ong HY, Lee BL, Ng TP and Teramoto K: Biological monitoring of exposure to low concentrations of styrene. Am J Ind Med 25, 719-730(1994)
11. Shi C-Y, Chua S-C, Lee B-L, Ong H-Y, Jeyaratnam J and Ong C-N: Kinetics of styrene urinary metabolites; a study in a low-level occupational exposure setting in Singapore. Int Arch Occup Environ Health 65, 319-323 (1994)
12. Jang J-Y, Droz PO and Berode M: Ethnic differences in biological monitoring of several organic solvents. I. Human exposure experiment. Int Arch Occup Environ Health 69, 343-349(1997)
13. Symanski E, Bergamaschi E and Mutti A: Inter- and intra-individual sources of variation in levels of urinary styrene metabolites. Int Arch Occup Environ Health 74,336-344(2001)
14. American Conference of Governmental Industrial Hygienists. 2007 TLVs® and BEIs® based on the documentation of the threshold limit values for chemical substances and physical agents, and biological exposure indices. Cincinnati: ACGIH, 2007.
15. Deutsche Forschungsgemeinschaft: List of MAK and BAT values 2006. Weinheim: Wiley-VCH, 2006.
16. Japan Society for Occupational Health: Recommendation of occupational exposure limits (2007-2008). J Occup Health 49, 328-344 (2007)
17. Huyser ES and Neckers DC: The photochemical reactions of alkyl phenylglyoxalates in alcohols. J Org Chem 29, 276-278(1963)
18. Guillemin MP and Bauer D: Human exposure to styrene. II. Quantitative and specific gaschromatographic analysis of urinary mandelic and phenylglyoxylic acids as an index of styrene exposure. Int Arch Occup Environ Health 37, 57-64 (1976)
19. Guillemin MP and Bauer D: Human exposure to styrene. III. Elimination kinetics of urinary mandelic and phenylglyoxylic acids after single experimental exposure. Int Arch Occup Environ Health 44, 249-263 (1979)
20. Kivistö H, Pekari K and Aitio A: Analysis and stability of phenylglyoxylic and mandelic acids in the urine of styrene-exposed people. Int Arch Occup Environ Health 64, 399-403 (1993)
21. Flek J and Šedivec V: Simultaneous gas chromatographic determination of urinary mandelic and phenylglyoxylic acids using diazomethane derivatization. IntArch Occup Environ Health 45, 181-188(1980)
22. Inoue O, Seiji K, Kudo S, Jin C, Cai S-X, Liu S-J, Watanabe T, Nakatsuka H and Ikeda M: A sensitive HPLC method for determination of mandelic acid in urine, and its application to biological monitoring of ethylbenzene-exposed Chinese workers. Int J Occup Environ Health 1, 245-251 (1995)
23. Guillemin MP and Bauer D (1978) Biological monitoring of exposure to styrene by analysis of combined urinary mandelic and phenylglyoxylic acids. Am Ind Hyg Ass J 39, 873-879.
24. Wigaeus E, Löf A, Bjurström R and Nordqvist MB (1983) Exposure to styrene; uptake, distribution, metabolism and elimination in man. Scand J Work Environ Health 9, 479-488.
25. Šperlingová I, Dabrowská L, Stránský V and Kučera J (2004) Human urine certified reference material CZ 6009; creatinine, styrene metabolites (mandelic acid and phenylglyoxylic acid). Anal Bioanal Chem 378, 1208-1212.