Elevated expression of phospholipid transfer protein in bone marrow derived cells causes atherosclerosis

PLoS ONE

Volumn 3, Issue 5, 2008, Pages

  van Haperen, Rien ^a   Samyn, Hannelore ^a   Moerland, Matthijs ^a   van Gent, Teus ^a   Peeters, Marian ^a   Grosveld, Frank ^a   van Tol, Arie ^a   de Crom, Rini ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN RECEPTOR; PHOSPHOLIPID TRANSFER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL ISOLATION; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOKINE PRODUCTION; HOMOZYGOSITY; IMMUNOHISTOCHEMISTRY; LIPID BLOOD LEVEL; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; GENETICS; MACROPHAGE; METABOLISM; PHYSIOLOGY;

MUS; MUS MUSCULUS;

ANIMALS; ATHEROSCLEROSIS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHOLIPID TRANSFER PROTEINS; RECEPTORS, LDL;

EID: 48249142373     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002255     Document Type: Article

References (53)

1. Tall AR (1980) Studies on the transfer of phosphatidylcholine from unilamellar vesicles into plasma high density lipoproteins in the rat. J Lipid Res 21: 354-363.
2. Damen J, Regts J, Scherphof G (1982) Transfer of [14C]phosphatidylcholine between liposomes and human plasma high density lipoprotein. Partial purification of a transfer-stimulating plasma factor using a rapid transfer assay. Biochim Biophys Acta 712: 444-452.
3. Tall AR, Abreu E, Shuman J (1983) Separation or a plasma phospholipid transfer protein from cholesterol ester/phospholipid exchange protein. J Biol Chem 258: 2174-2180.
4. Albers JJ, Cheung MC (2004) Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism. Curr Opin Lipidol 15: 255-260.
5. Kostner GM, Oettl K, Jauhiainen M, Ehnholm C, Esterbauer H, et al. (1995) Human plasma phospholipid transfer protein accelerates exchange/ transfer of alpha-tocopherol between lipoproteins and cells. Biochem J 305: 659-667.
6. Tu AY, Nishida HI, Nishida T (1993) High density lipoprotein conversion mediated by human plasma phospholipid transfer protein. J Biol Chem 268: 23098-23105.
7. Jauhiainen M, Metso J, Pahlman R, Blomqvist S, van Tol A, et al. (1993) Human plasma phospholipid transfer protein causes high density lipoprotein conversion. J Biol Chem 268: 4032-4036.
8. Assmann G, Gotto AM Jr (2004) HDL cholesterol and protective factors in atherosclerosis. Circulation 109: III8-14.
9. Ausell BJ, Navab M, Watson KE, Fonarow GC, Fogelman AM (2004) Anti-inflammatory properties of HDL. Rev Endocr Metab Disord 5: 351-358.
10. Barter PJ, Nicholls S, Rye KA, Anantharamaiah GM, Navab M, et al. (2004) Antiinflammatory properties of HDL. Circ Res 95: 764-772.
11. Huuskonen J, Olkkonen VM, Jauhiainen M, Ehnholm C (2001) The impact of phospholipid transfer protein (PLTP) on HDL metabolism. Atherosclerosis 155: 269-281.
12. van Tol A (2002) Phospholipid transfer protein. Curr Opin Lipidol 13: 135-139.
13. Jiang XC, Bruce C, Mar J, Lin M, Ji Y, et al. (1999) Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest 103: 907-914.
14. van Haperen R, van Tol A, Vermeulen P, Jauhiainen M, van Gent T, et al. (2000) Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice. Arterioscler Thromb Vasc Biol 20: 1082-1088.
15. Fielding CJ, Fielding PE (2001) Cellular cholesterol efflux. Biochim Biophys Acta 1533: 175-189.
16. Jiang XC, Qin S, Qiao C, Kawano K, Lin M, et al. (2001) Apolipoprotein B secretion and atherosclerosis are decreased in mice with phospholipid-transfer protein deficiency. Nat Med 7: 847-852.
17. Van Haperen R, Van Tol A, Van Gent T, Scheek L, Visser P, et al. (2002) Increased risk of atherosclerosis by elevated plasma levels of phospholipid transfer protein. J Biol Chem 277: 48938-48943.
18. Lie J, De Crom R, Van Gent T, Van Haperen R, Scheek L, et al. (2002) Elevation of plasma phospholipid transfer protein in transgenic mice increases VLDL secretion. J Lipid Res 43: 1875-1880.
19. Jiang XC, Tall AR, Qin S, Lin M, Schneider M, et al. (2002) Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem 277: 31850-31856.
20. Day JR, Albers JJ, Lofton-Day CE, Gilbert TL, Ching AF, et al. (1994) Complete cDNA encoding human phospholipid transfer protein from human endothelial cells. J Biol Chem 269: 9388-9391.
21. Albers JJ, Wolfbauer G, Cheung MC, Day JR, Ching AF, et al. (1995) Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies. Biochim Biophys Acta 1258: 27-34.
22. Laffitte BA, Joseph SB, Chen M, Castrillo A, Repa J, et al. (2003) The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Mol Cell Biol 23: 2182-2191.
23. O'Brien KD, Vuletic S, McDonald TO, Wolfbauer G, Lewis K, et al. (2003) Cell-Associated and Extracellular Phospholipid Transfer Protein in Human Coronary Atherosclerosis. Circulation.
24. Okabe M, Ikawa M, Kominami K, Nakanishi T, Nishimune Y (1997) 'Green mice' as a source of ubiquitous green cells. FEBS Lett 407: 313-319.
25. Peeters M, Ling KW, Oziemlak A, Robin C, Dzierzak E (2005) Multipotential hematopoietic progenitor cells from embryos developed in vitro engraft unconditioned W41/W41 neonatal miceB. Haematologica 90: 734-739.
26. van Haperen R, de Waard M, van Decl E, Mees B, Kutryk M, et al. (2002) Reduction of blood pressure, plasma cholesterol, and afherosclerosis by elevated endothelial nitric oxide. J Biol Chem 277: 18803-18807.
27. Bouma G, Nikolic T, Coppens JM, van Helden-Meeuwsen CG, Leenen PJ, et al. (2005) NOD mice have a severely impaired ability to recruit leukocytes into sites of inflammation. Eur J Immunol 35: 225-235.
28. Rothblat GH, Bamberger M, Phillips MC (1986) Reverse cholesterol transport. Methods Enzymol 129: 628-644.
29. Basu SK, Goldstein JL, Anderson GW, Brown MS (1976) Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc Natl Acad Sci U S A 73: 3178-3182.
30. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
31. Lie J, De Crom R, Van Gent T, Van Haperen R, Scheek L, et al. (2004) Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis in spite of lowering apolipoprotein B containing lipoproteins. J Lipid Res 45: 805-811.
32. Desrumaux CM, Mak PA, Boisvert WA, Masson D, Stupack D, et al. (2003) Phospholipid transfer protein is present in human atherosclerotic lesions and is expressed by macrophages and foam cells. J Lipid Res 44: 1453-1461.
33. Stein O, Stein Y (2005) Lipid transfer proteins (LTP) and atherosclerosis. Atherosclerosis 178: 217-230.
34. Colhoun HM, Taskinen MR, Otvos JD, Van Den Berg P, O'Connor J, et al. (2002) Relationship of Phospholipid Transfer Protein Activity to HDL and Apolipoprotein B-Containing Lipoproteins in Subjects With and Without Type 1 Diabetes. Diabetes 51: 3300-3305.
35. Riemens SC, van Tol A, Sluiter WJ, Dullaart RP (1998) Plasma phospholipid transfer protein activity is related to insulin resistance: impaired acute lowering by insulin in obese Type II diabetic patients. Diabetologia 41: 929-934.
36. Desrumaux C, Athias A, Bessede G, Verges B, Farnier M, et al. (1999) Mass concentration of plasma phospholipid transfer protein in normolipidemic, type IIa hyperlipidemic, type IIb hyperlipidemic, and non-insulin-dependent diabetic subjects as measured by a specific ELISA. Arterioscler Thromb Vasc Biol 19: 266-275.
37. Dullaart RP, Sluiter WJ, Dikkeschei LD, Hoogenberg K, Van Tol A (1991) Effect of adiposity on plasma lipid transfer protein activities: a possible link between insulin resistance and high density lipoprotein metabolism. Eur J Clin Invest 24: 188-194.
38. Cheung MC, Knopp RH, Retzlaff B, Kennedy H, Wolfbauer G, et al. (2002) Association of plasma phospholipid transfer protein activity with IDL and buoyant LDL: impact of gender and adiposity. Biochim Biophys Acta 1587: 53-59.
39. Kaser S, Sandhofer A, Foger B, Ebenbichler CF, Igelseder B, et al. (2001) Influence of obesity and insulin sensitivity on phospholipid transfer protein activity. Diabetologia 44: 1111-1117.
40. Murdoch SJ, Carr MC, Hokanson JE, Brunzell JD, Albers JJ (2000) PLTP activity in premenopausal women. Relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance. J Lipid Res 41: 237-244.
41. Murdoch SJ, Kahn SE, Albers JJ, Brunzell JD, Purnell JQ (2003) PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity. J Lipid Res 44: 1705-1712.
42. de Vries R, Dallinga-Thie GM, Smit AJ, Wolffenbuttel BH, van Tol A, et al. (2006) Elevated plasma phospholipid transfer protein activity is a determinant of carotid intima-media thickness in type 2 diabetes mellitus. Diabetologia 49: 398-404.
43. Foger B, Santamarina-Fojo S, Shamburek RD, Parrot CL, Talley GD, et al. (1997) Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL. J Biol Chem 272: 27393-27400.
44. Ehnholm S, van Dijk KW, van 't Hof B, van der Zee A, Olkkonen VM, et al. (1998) Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice. J Lipid Res 39: 1248-1253.
45. Yan D, Navab M, Bruce C, Fogelman AM, Jiang XC (2004) PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activity. J Lipid Res 45: 1852-1858.
46. Schlitt A, Liu J, Yan D, Mondragon-Escorpizo M, Norin AJ, et al. (2005) Anti-inflammatory effects of phospholipid transfer protein (PLTP) deficiency in mice. Biochim Biophys Acta 1733: 187-191.
47. Cheung MC, Brown BG, Marino Larsen EK, Frutkin AD, O'Brien KD, et al. (2005) Phospholipid transfer protein activity is associated with inflammatory markers in patients with cardiovascular disease. Biochim Biophys Acta 1762: 131-137.
48. Karkkainen M, Oka T, Olkkonen VM, Metso J, Hattori H, et al. (2002) Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP). J Biol Chem 277: 15413-15418.
49. Valenta DT, Ogier N, Bradshaw G, Black AS, Bonnet DJ, et al. (2006) Atheroprotective Potential of Macrophage-Derived Phospholipid Transfer Protein in Low-Density Lipoprotein Receptor-Deficient Mice Is Overcome by Apolipoprotein AI Overexpression. Arterioscler Thromb Vasc Biol.
50. Vikstedt R, Ye D, Metso J, Hildebrand RB, Van Berkel TJ, et al. (2007) Macrophage phospholipid transfer protein contributes significantly to total plasma phospholipid transfer activity and its deficiency leads to diminished atherosclerotic lesion development. Arterioscler Thromb Vasc Biol 27: 378-386.
51. Valenta DT, Bulgrien JJ, Bonnet DJ, Curtiss LK (2008) Macrophage PLTP is atheroprotective in LDLr-deficient mice with systemic PLTP deficiency. J Lipid Res 49: 24-32.
52. Lie J, Moerland M, van Gent T, van Haperen R, Scheek I, et al. (2006) Sex differences in atherosclerosis in mice with elevated phospholipid transfer protein activity are related to decreased plasma high density lipoproteins and not to increased production of triglycerides. Biochim Biophys Acta 1761: 1070-1077.
53. Jordan CT, Lemischka IR (1990) Clonal and systemic analysis of long-term hematopoiesis in the mouse. Genes Dev 4: 220-232.