Improved mass determination of poly(ethylene glycols) by electrospray ion-mobility time-of-flight mass spectrometry coupled with ion-molecule reactions

Pharmaceutical Technology

Volumn 32, Issue 7, 2008, Pages 80-87

  Chakraborty, Asish B ^a   Chen, Weibin ^a   Gebler, John C ^a  

^a WATERS CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC COMPOUNDS; ELECTROSPRAY IONIZATION; ETHYLENE; ETHYLENE GLYCOL; GLYCOLS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION OF GASES; MASS SPECTROMETERS; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOLECULAR WEIGHT DISTRIBUTION; MOLECULES; NEGATIVE IONS; POLYETHYLENE GLYCOLS; SEPARATION; SPECTROMETERS; SPECTROMETRY; SPECTRUM ANALYSIS;

AVERAGE MOLECULAR; CHARGE STATES; ELECTROSPRAY (ES); GAS PHASE; ION MOBILITIES; ION MOLECULE REACTIONS; MASS DETERMINATION; MULTIPLY CHARGED IONS; SPECTRAL CONGESTION; SYNTHETIC POLYMERS; TIME-OF-FLIGHT MASS SPECTROMETER (TOFMS); TIME-OF-FLIGHT MASS SPECTROMETRY (TOF-MS); WEIGHT DISTRIBUTIONS;

IONS;

MACROGOL;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; ELECTROSPRAY MASS SPECTROMETRY; GAS; MASS SPECTROMETRY; MOLECULAR WEIGHT; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 48249135461     PISSN: 15432521     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. J.M. Harris, Introduction to Biotechnical and Biomedical Applications of Poly(Ethylene Glycol) in Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications (Topics in Applied Chemistry), J.M. Harris, Ed. (Plenum, New York, 1992).
2. A. Kozlowski and J. M. Harris, "Improvements in Protein PEGylation: Pegylated Interferons for Treatment of Hepatitis C," J. Controlled Release 72, 217-224 (2001).
3. D.J. Winzor. "Analytical Exclusion Chromatography," J. Biochem. Biophys. Methods 56 (1-3), 15-52 (2003).
4. J.Y. Shey and C.M. Sun, "Liquid-Phase Combinatorial Reaction Monitoring by Conventional 1H NMR Spectroscopy,"Tetrahedron Lett. 43, 1725-1729 (2002).
5. J.L. Koenig and A.C. Angood, "Raman Spectra of Poly(ethylene glycols) in Solution," J. Polymer Sci. Part A-2: Polymer Physics 8 (10), 1787-1796 (1970).
6. P.B. O'Connor and F.W. McLafferty, "Oligomer Characterization of 4-23 kDa Polymers by Electrospray Fourier Transform Mass Spectrometry," J. Am. Chem. Soc. 117, 12826-12831 (1995).
7. S.D. Hanton, "Mass Spectrometry of Polymers and Polymer Surfaces," Chem. Rev. 101 (2), 527-570 (2001).
8. C.G. de Koster et al. "Endgroup analysis of Polyethylene Glycol Polymers by Matrix-Assisted Laser Desorption/Ionization Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry," Rapid Commun. Mass Spectrom. 9 (10), 957-962 (1995).
9. L.M. Nuwaysir, C.L. Wilkins, and W.J. Simonsick, Jr., "Analysis of Copolymers by Laser Desorption Fourier Transform Mass Spectrometry," J. Am. Soc. Mass Spectrom. 1, 66-71 (1990).
10. E.P. Maziarz, III, G.A. Baker, and T.D. Wood. "Capitalizing on the High Mass Accuracy of Electrospray Ionization Fourier Transform Mass Spectrometry for Synthetic Polymer Characterization: A Detailed Investigation of Poly(dimethylsiloxane)," Macromolecules 32, 4411-4418 (1999).
11. M.W.F. Nielen, "MALDI Time-of-Flight Mass Spectrometry of Synthetic Polymers," Mass Spectrom. Rev. 18, 309-344 (1999).
12. T. Nohmi and J.B. Fenn "Electrospray Mass Spectrometry of Poly(ethylene glycols) with Molecular Weights up to Five Million" J. Am. Chem. Soc. 114, 3241-3246 (1992).
13. J.J. Palmgred et al.,"Liquid Chromatographic-Electrospray Ionization Mass Spectrometric Analysis of Neutral and Charged Polyethylene Glycols," J. Chromatogr. A 976, 165-170 (2002).
14. J.D. Lennon, S.P. Cole, and G.L. Glish, "Ion-Molecule Reactions To Chemically Deconvolute the Electrospray Ionization MassSpectra of Synthetic Polymers," Anal. Chem. 78, 8472-8476 (2006).
15. D. Bagal, H. Zhang, and P.D. Schnier, "Gas-Phase Proton-Transfer Chemistry Coupled with TOF Mass Spectrometry and Ion Mobility-MS for the Facile Analysis of Poly(ethylene glycols) and PEGylated Polypeptide Conjugates," Anal. Chem. 80, 2408-2418 (2008).
16. J.L. Stephenson and S.A. McLuckey, "Reactions of Poly(ethylene glycol) Cations with Iodide and Perfluorocarbon Anions," J. Am. Soc. Mass Spectrom. 9, 957-9651, (1998).
17. S. D. Pringle et al., "An Investigation of the Mobility Separation of Some Peptide and Protein Ions Using a New Hybrid Quadrupole/Travelling Wave IMS/oa-TOF Instrument." Int. J. Mass Spectrom. 261, 1-12 (2007).
18. K. Giles et al., "Applications of a travelling Wave-Based Radio-Frequency Only Stacked Ring Ion Guide," Rapid Commun. Mass Spectrom. 18, 2401-2414 (2004).