An usual case of acute brucellosis presenting with coombs-positive autoimmune hemolytic anemia

Internal Medicine

Volumn 47, Issue 11, 2008, Pages 1043-1045

  Sari, Ismail ^a   Kocyigit, Ismail ^b   Altuntäs, Fevzi ^b   Kaynar, Leylagul ^b   Eser, Bulent ^b  

^a PAMUKKALE UNIVERSITY   (Turkey)

^b ERCIYES UNIVERSITY   (Turkey)

Author keywords

Autoimmune hemolytic anemia; Brucella; Brucellosis; Coombs positive

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CORTICOSTEROID; DOXYCYCLINE; HEMOGLOBIN; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE; RIFAMPICIN;

ACUTE DISEASE; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOIMMUNE HEMOLYTIC ANEMIA; BILIRUBIN BLOOD LEVEL; BRUCELLA MELITENSIS; BRUCELLOSIS; CASE REPORT; COOMBS POSITIVE HEMOLYTIC ANEMIA; DRUG PULSE THERAPY; FEMALE; FEVER; FOLLOW UP; HEPATOMEGALY; HOSPITAL ADMISSION; HUMAN; JAUNDICE; LACTATE DEHYDROGENASE BLOOD LEVEL; LYMPHADENOPATHY; MAINTENANCE THERAPY; PHYSICAL EXAMINATION; RETICULOCYTE; WEAKNESS; BLOOD; COOMBS TEST; DIFFERENTIAL DIAGNOSIS; THROMBOCYTE COUNT;

ACUTE DISEASE; ADULT; ANEMIA, HEMOLYTIC, AUTOIMMUNE; BRUCELLOSIS; COOMBS' TEST; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; PLATELET COUNT;

EID: 48249128764     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.47.1000     Document Type: Article

References (17)

1. Corbel MJ, Beeching NJ. Brucellosis. In: Harrison's Principles of Internal Medicine. 16th ed. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, Eds. McGraw-Hill, New York, 2005: 914-917.
2. Pappas G, Papadimitriou P, Akriditis N, Christou L, Tsianos EV. The new global map of human brucellosis. Lancet Infect Dis 6: 91-99, 2006.
3. Summaries of Infectious Diseases. In: Red Book: Report of the Committee on Infectious Diseases. 24th ed. Peter G, Ed. American Academy of Pediatrics, Elk Grove Village, IL, 1997: 157-159.
4. Colmenero JD, Reguera JM, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 75: 195-211, 1996.
5. Crosby E, Hosa L, Miro Quesada M, et al. Hematologic changes in brucellosis. J Infect Dis 150: 419-424, 1984.
6. Al-Eissa Y, al-Nasser M. Haematological manifestations of childhood brucellosis. Infection 21: 23-26, 1993.
7. Young ES. Brucella species. In: Principles and Practice of Infectious Diseases. 4th ed. Mandell GL, Bennet JE, Dolin R, Eds. Churchill Livingstone, New York, 1995: 2053-2060.
8. Sari I, Altuntas F, Hacioglu S, et al. A multicenter retrospective study defining the clinical and hematological manifestations of brucellosis and pancytopenia in a large series: Hematological malignancies, the unusual cause of pancytopenia in patients with brucellosis. Am J Hematol 83: 334-339, 2008.
9. Altuntas F, Yildiz O, Sari I, Eser B, Cetin M, Unal A. Intravenous gamma globulin is effective as an urgent treatment in Brucella-induced severe thrombocytopenic purpura. Am J Hematol 80: 204-206, 2005.
10. Altuntas F, Eser B, Sari I, Yildiz O, Cetin M, Unal A. Severe thrombotic microangiopathy associated with brucellosis: Successful treatment with plasmapheresis. Clin Appl Thromb Hemost 11: 105-108, 2005.
11. Gotuzzo E, Bocanegra TS, Alarcon GS, Carrilo C, Espinoza LR. Humoral immune abnormalities in human brucellosis. Allegrol Immunopathol 13: 417-424, 1985.
12. Cannat A, Escande A, Peraldi F, Serre A. Induction of autoantibodies in circulating immune complexes in mice after injection of Brucella fraction "PI" or inoculation with live Brucella suis. Ann Immunol (Paris) 134: 43-53, 1983.
13. Benecos P, Spingou T, Galanakis E, Lapatsanis PD. Thrombocytopenic purpura secondary to brucellosis. Eur J Pediatr 157: 698, 1998.
14. Todd KH, Lyde PB. Brucellosis and thrombocytopenic purpura: case report and review. Tex Med 85: 37-38, 1989.
15. Yaramis A, Kervancioglu M, Yildirim I, Soker M, Derman O, Tas MA. Severe microangiopathic hemolytic anemia and thrombocytopenia in a child with Brucella infection. Ann Hematol 80: 546-548, 2001.
16. Murrin RJ, Murray JA. Thrombotic thrombocytopenic purpura: aetiology, pathophysiology and treatment. Blood Rev 20: 51-60, 2006.
17. Jefferies LC. Transfusion therapy in autoimmune hemolytic anemia. Hematol Oncol Clin North Am 8: 1087-1104, 1994.