Multiple tumors in a child with germ-line mutations in TP53 and PTEN

New England Journal of Medicine

Volumn 359, Issue 5, 2008, Pages 537-539

  Plon, Sharon E ^a   Pirics, Michael L ^a   Nuchtern, Jed ^a   Hicks, John ^a   Russell, Heidi ^a   Agrawal, Shipra ^b   Zbuk, Kevin ^b   Eng, Charis ^b   Hegde, Madhuri ^c   Chin, Ephrem Lip Hon ^c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P53;

ABDOMINAL WALL LIPOMA; ANAMNESIS; CANCER STAGING; CASE REPORT; CLINICAL FEATURE; FAMILIAL CANCER; FEMALE; GENE MUTATION; GERM LINE; GRANULOSA CELL TUMOR; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; INHERITANCE; LETTER; LIPOMA; MULTIPLE CANCER; NEUROBLASTOMA; OVARY TUMOR; PRIORITY JOURNAL; SCHOOL CHILD;

EID: 48249117488     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc0800627     Document Type: Letter

References (5)

1. Birch JM, Alston RD, McNally RJ, et al. Relative frequency and morphology of cancers in carriers of germline TP53 mutations. Oncogene 2001;20:4621-8.
2. Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004;22:2954-63.
3. Knudson AG. Two genetic hits (more or less) to cancer. Nat Rev Cancer 2001;1:157-62.
4. Freeman DJ, Li AG, Wei G, et al. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell 2003;3:117-30.
5. Hisada M, Garber JE, Fung CY, Fraumeni JF Jr, Li FP. Multiple primary cancers in families with Li-Fraumeni syndrome. J Natl Cancer Inst 1998;90:606-11.