Successful treatment of extensive infantile hemangiomatosis of the small bowel in a 3-month-old with thalidomide and somatostatin analog

Journal of Pediatric Gastroenterology and Nutrition

Volumn 46, Issue 5, 2008, Pages 593-597

  Jarvi, Kristiina ^a   Roebuck, Derek J ^a   Sebire, Neil J ^a   Lindley, Keith ^a   Shah, Neil ^a   Salomon, Julie ^a   Curry, Joe I ^a  

^a GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPEPTIN; ERYTHROCYTE TC 99M; GLUCOSE TRANSPORTER 1; HEMOGLOBIN; THALIDOMIDE; ANGIOGENESIS INHIBITOR; DRUG DERIVATIVE; SOMATOSTATIN;

ARTICLE; BIOPSY; BLOOD SAMPLING; BLOOD TRANSFUSION; CASE REPORT; COLONOSCOPY; DRUG WITHDRAWAL; ECCHYMOSIS; ERYTHEMA; ERYTHROCYTE SEDIMENTATION RATE; FECES ANALYSIS; FEMALE; GASTROINTESTINAL ENDOSCOPY; GASTROINTESTINAL TRACT SCINTISCANNING; HEMANGIOMATOSIS; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; ILEUM; IMMUNOHISTOCHEMISTRY; INFANT; INTESTINE BIOPSY; JEJUNUM; LAPAROSCOPY; PRIORITY JOURNAL; SMALL INTESTINE; SUPERIOR MESENTERIC ANGIOGRAPHY; HEMANGIOMA; INTESTINE TUMOR; TREATMENT OUTCOME;

ANGIOGENESIS INHIBITORS; FEMALE; HEMANGIOMA; HUMANS; INFANT; INTESTINAL NEOPLASMS; SOMATOSTATIN; THALIDOMIDE; TREATMENT OUTCOME;

EID: 48249102719     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e31814794ce     Document Type: Article

References (12)

1. Varma JD, Hill MC, Harvey LA. Hemangioma of the small intestine manifesting as gastrointestinal bleeding. Radiographics 1998;18: 1029-33.
2. Morgan DR, Mylankal K, El Barghouti N, et al. Small bowel haemangioma with local lymph node involvement presenting as intussusception. J Clin Pathol 2000;53:552-3.
3. Fishman SJ, Burrows PE, Leichtner AM, et al. Gastrointestinal manifestations of vascular anomalies in childhood: varied etiologies require multiple therapeutic modalities. J Pediatr Surg 1998;33: 1163-7.
4. Gampper TJ, Morgan RE Vascular anomalies: hemangiomas. Plast Reconstr Surg 2002;110:572-85.
5. Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg 1982;69:412-22.
6. Puig S, Casati B, Staudenherz A, et al. Vascular low-flow malformations in children: current concepts for classification, diagnosis, and therapy. Eur J Radiol 2005;53:35-45.
7. North PE, Waner M, Mizeracki A, et al. GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol 2000;31:11-22.
8. Yabu T, Tomimoto H, Taguchi Y, et al. Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1 -phosphate. Blood 2005;106:125-34.
9. Florio T, Morini M, Villa V, et al. Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3 -mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities. Endocrinology 2003;144: 1574-84.
10. Frieden IJ, Haggstrom AN, Drolet BA, et al. Infantile hemangiomas: current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas. Pediatr Dermatol 2005;22:383-406.
11. Facchini S, Candusso M, Martelossi S, et al. Efficacy of long-term treatment of thalidomide in children and young adults with Crohn disease: preliminary results. J Pediatr Gastroenterol Nutr 2001;32: 178-81.
12. Kieran MW, Turner CD, Rubin JB, et al. A feasibility trial of antiangiogenic (metronomic) chemotherapy in pediatric patients with recurrent or progressive cancer. J Pediatr Hematol Oncol 2005;27:573-81.