The new renin antagonist: Aliskiren

U.S. Pharmacist

Volumn 33, Issue 2, 2008, Pages 38-42

  Butler, Lakesha ^a   Lynch, Chris ^a  

^a SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALISKIREN; AMLODIPINE; ANGIOTENSIN; ATORVASTATIN; CYTOCHROME P450 3A4; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FUROSEMIDE; HYDROCHLOROTHIAZIDE; IRBESARTAN; KETOCONAZOLE; PLACEBO; POTASSIUM; RAMIPRIL; RENIN; VALSARTAN; WARFARIN;

ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; COMORBIDITY; DIARRHEA; DIASTOLIC BLOOD PRESSURE; DRUG ABSORPTION; DRUG CONTRAINDICATION; DRUG COST; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG SAFETY; HUMAN; HYPERTENSION; MONOTHERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATIENT COMPLIANCE; PATIENT COUNSELING; PLASMA RENIN ACTIVITY; POTASSIUM BLOOD LEVEL; PREGNANCY; REBOUND; RENIN RELEASE; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; WITHDRAWAL SYNDROME;

EID: 48249087717     PISSN: 01484818     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (8)

1. Tekturna (aliskiren) package insert. East Hanover, NJ: Novartis; March 2007.
2. Villamil A, Chrysant SG, Calhoun D, et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with HCTZ. J Hypertens. 2007; 25:217-226.
3. Tektuma (aliskiren) Formulary Submission Dossier. Prepared by Novartis US Clinical Development and Medical Affairs. Release date: March 16, 2007.
4. Pool JL, Schmieder RE, Azizi M, et al. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens. 2007;20:11-20.
5. Uresin Y, Taylor A, Kilo C, et al. Aliskiren, a novel renin inhibitor, has greater BP lowering than ramipril and additional BP-lowering when combined with ramipril in patients with diabetes and hypertension. J Hypertens. 2006;24(suppl 4):S82.
6. Jordan J, Engeli S, Boye SW, et al. Direct renin inhibition with aliskiren in obese patients wfth arterial hypertension. Hypertension, 2007;49:1047-1655.
7. Prescription price. Tektuma. Available at: www.drugstore.com. Accessed December 14, 2007.
8. Tekturna HCT (aliskiren and hydrochlorothiazide) package insert. East Hanover, NJ: Novartis; January 2008.