Preparation of MBHA resin by benzotriazole-mediated amidoalkylation

Tetrahedron Letters

Volumn 49, Issue 37, 2008, Pages 5380-5382

  Lee, Tae Kyung ^a   Choi, Jeong Hyun ^a   Byun, Jang Woong ^a   Lee, Yoon Sik ^a  

^a Seoul National University   (South Korea)

Author keywords

1 Benzotriazole; Amidoalkylation; MBHA resin; Solid phase peptide synthesis

Indexed keywords

4 METHYLBENZYLHYDRYLAMINEN [(BENZOTRIAZOL 1 YL)(4 TOYL)METHYL]FORMAMIDE; 4 METHYLBENZYLHYDRYLAMINEN RESIN; BENZOTRIAZOLE DERIVATIVE; FORMAMIDE; N [(BENZOTRIAZOL 1 YL)(4 TOYL)METHYL]FORMAMIDE; N [FORMAMIDO(4 TOYL)METHYL]FORMAMIDE;

ALKYLATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 48149115841     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.06.110     Document Type: Article

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16. f = 0.17), N-[phenyl(p-tolyl)methyl]formamide (2) was obtained as white solid (0.10 g, 12% yield).
17. -1, N analysis: 1.695%, the loading level 1.21 mmol/g resin.