Liver HIF-1 Alpha Induction Precedes Apoptosis Following Normothermic Ischemia-Reperfusion in Rats

Transplantation Proceedings

Volumn 40, Issue 6, 2008, Pages 2042-2045

  Cursio, R ^a,b   Miele, C ^c,d   Filippa, N ^c   Van Obberghen, E ^c   Gugenheim, J ^a,b  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^c INSERM   (France)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIVER EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; LIVER ISCHEMIA; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; REPERFUSION INJURY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IN SITU NICK-END LABELING; LIVER; MALE; RATS; RATS, INBRED LEW; REPERFUSION INJURY;

EID: 48049099965     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2008.05.037     Document Type: Article

References (16)

1. Selzner N., Rudiger H., Graf R., et al. Protective strategies against ischemic injury of the liver. Gastroenterology 125 (2003) 917
2. Farmer D.G., Amersi F., and Kupiec-Weglinski J.W. Current status of ischemia and reperfusion injury in the liver. Transplant Rev 14 (2000) 106
3. Cursio R., Gugenheim J., Ricci J.E., et al. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis. FASEB J 13 (1999) 253
4. Hoglen N.C., Anselmo D.M., Katori M., et al. A caspase inhibitor, IDN-6556, ameliortaes early hepatic injury in an ex vivo model of warm and cold ischemia. Liver Transpl 13 (2007) 361
5. Baskin-Bey E.S., Washburn K., Feng S., et al. Clinical trial of the pan-caspase inhibitor, IDN-6556, in human liver preservation injury. Am J Transplant 7 (2007) 218
6. Boros P., Tarcsafalvi A., Wang L., et al. Intrahepatic expression and release of vascular endothelial growth factor following orthotopic liver transplantation in the rat. Transplantation 72 (2001) 805
7. Tsurui Y., Sho M., Kuzumoto Y., et al. Dual role of vascular endothelial growth factor in hepatic ischemia-reperfusion injury. Transplantation 79 (2005) 1110
8. Cursio R., Filippa N., Miele C., et al. Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury. Br J Surg 93 (2006) 752
9. Tacchini L., Radice L., and Bernelli-Zazzera A. Differential activation of some transcription factors during rat liver ischemia, reperfusion, and heat shock. J Cell Physiol 180 (1999) 255
10. Tacchini L., Fusar Poli D., Bernelli-Zazzera A., et al. Transferrin receptor gene expression and transferrin-bound iron uptake are increased during postischemic rat liver reperfusion. Hepatology 36 (2002) 103
11. Semenza G.L. Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Exp Physiol 91 (2006) 803
12. Piret J.-P., Mottet D., Raes M., and Michiels C. Is HIF-1α a pro- or an anti-apoptotic protein?. Biochem Pharmacol 64 (2002) 889
13. Cursio R., Filippa N., Miele C., et al. Fas ligand expression following normothermic liver ischemia-reperfusion. J Surg Res 125 (2005) 30
14. Forsyte J.A., Jiang B.H., Iyer N.V., et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16 (1996) 4604
15. Ozaki H., Yu A.Y., Della N., et al. Hypoxia inducible factor-1alpha is increased in ischemic retina: temporal and spatial correlation with VEGF expression. Invest Ophthalmol Vis Sci 40 (1999) 182
16. Cursio R., Miele C., Filippa N., et al. Alterations in protein tyrosine kinase pathways in rat liver following normothermic ischemia-reperfusion. Transplant Proc 38 (2006) 3362