Paroxetine for patients with undifferentiated somatoform disorder: A prospective, open-label, 8-week pilot study

Current Therapeutic Research - Clinical and Experimental

Volumn 69, Issue 3, 2008, Pages 221-231

  Han, Changsu ^a,b   Marks, David M ^b   Pae, Chi Un ^b,c   Lee, Bun Hee ^a   Ko, Young Hoop ^a   Masand, Prakash S ^b   Patkar, Ashwin A ^b   Jung, In Kwa ^a  

^a Korea University College of Medicine   (South Korea)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c The Catholic University of Korea   (South Korea)

Author keywords

paroxetine; Patient Health Questionnaire; pilot study; undifferentiated somatoform disorder

Indexed keywords

ALPRAZOLAM; IBUPROFEN; LORAZEPAM; PARACETAMOL; PAROXETINE;

ADULT; ANXIETY DISORDER; ARTICLE; BLOOD CELL COUNT; CLINICAL ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE SEVERITY; DIZZINESS; DRUG EFFECT; DRUG TOLERABILITY; FEMALE; FOLLOW UP; HEADACHE; HUMAN; LABORATORY TEST; MALE; NAUSEA; OUTPATIENT CARE; PILOT STUDY; PREGNANCY TEST; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUESTIONNAIRE; SIDE EFFECT; SOMATOFORM DISORDER; SOMNOLENCE; SWEATING; VITAL SIGN; XEROSTOMIA; YAWNING;

EID: 48049099922     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.curtheres.2008.06.004     Document Type: Article

References (31)

1. Khan A., Khan A., Harezlak J., et al. Somatic symptoms in primary care: Etiology and outcome. Psychosomatics 44 (2003) 471-478
2. Katon W Lin E., Von Korff M., et al. Somatization: A spectrum of severity. Am J Psychiatry 148 (1991) 34-40
3. Smith Jr. G., Monson R., and Ray D. Patients with multiple unexplained symptoms. Their characteristics, functional health, and health care utilization. Arch Intern Med 146 (1986) 69-72
4. Kroenke K. Patients presenting with somatic complaints: Epidemiology, psychiatric comorbidity and management. Int J Methods Psychiatr Res 12 (2003) 34-43
5. O'Malley P., Jackson J., Santoro J., et al. Antidepressant therapy for unexplained symptoms and symptom syndromes. J Fam Pract 48 (1999) 980-990
6. O'Malley P., Balden E., Tomkins G., et al. Treatment of fibromyalgia with antidepressants: A meta-analysis. J Gen Intern Med 15 (2000) 659-666
7. Saarto T., and Wiffen P. Antidepressants for neuropathic pain. Cochrane Database Syst Rev 4 (2007) CD005454
8. Tomkins G., Jackson J., O'Malley P., et al. Treatment of chronic headache with antidepressants: A meta-analysis. Am J Med 111 (2001) 54-63
9. Spitzer R., Kroenke K., and Williams J. Validation and utility of a self-report version of PRIME-MD: The PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA 282 (1999) 1737-1744
10. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (1994), American Psychiatric Association Press, Washington, DC
11. Kroenke K., Spitzer R., and Williams J. The PHQ-15: Validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med 64 (2002) 258-266
12. Beck A., Ward C., Mendelson M., et al. An inventory for measuring depression. Arch Gen Psychiatry 4 (1961) 561-571
13. Goldberg D., and Blackwell B. Psychiatric illness in general practice. A detailed study using a new method of case identification. Br Med J 1 (1970) 439-443
14. Rabkin J., Markowitz J., Ocepek-Welikson K., and Wager S. General versus systematic inquiry about emergent clinical events with SAFTEE: Implications for clinical research. J Clin Psychopharmacol 12 (1992) 3-10
15. Kroenke K., Messina III N., Benattia I., et al. Venlafaxine extended release in the short-term treatment of depressed and anxious primary care patients with multisomatoform disorder. J Clin Psychiatry 67 (2006) 72-80
16. De Wilde J., Spiers R., Mertens C., et al. A double-blind, comparative, multicentre study comparing paroxetine with fluoxetine in depressed patients. Acta Psychiatr Scand 87 (1993) 141-145
17. Fabre L. A 6-week, double-blind trial of paroxetine, imipramine, and placebo in depressed outpatients. J Clin Psychiatry 53 Suppl (1992) 40-43
18. Tignol J. A double-blind, randomized, fluoxetine-controlled, multicenter study of paroxetine in the treatment of depression. J Clin Psychopharmacol 13 Suppl 2 (1993) 18S-22S
19. Cohn J., Crowder J., Wilcox C., and Ryan P. A placebo- and imipramine-controlled study of paroxetine. Psychopharmacol Bull 26 (1990) 185-189
20. Doraiswamy P., Varia I., Hellegers C., et al. A randomized controlled trial of paroxetine for noncardiac chest pain. Psychopharmacol Bull 39 (2006) 15-24
21. Patkar A., Masand P., Krulewicz S., et al. A randomized, controlled, trial of controlled release paroxetine in fibromyalgia. Am J Med 120 (2007) 448-454
22. Creed F., Fernandes L., Guthrie E., et al., for the North of England IBS Research Group. The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome. Gastroenterology 124 (2003) 303-317
23. Bird H., and Broggini M. Paroxetine versus amitriptyline for treatment of depression associated with rheumatoid arthritis: A randomized, double blind, parallel group study. J Rheumatol 27 (2000) 2791-2797
24. Masand P., Narasimhan M., and Patkar A. Paroxetine for somatic pain associated with physical illness: A review. Prim Care Companion J Clin Psychiatry 8 (2006) 122-130
25. Greco T., Eckert G., and Kroenke K. The outcome of physical symptoms with treatment of depression. J Gen Intern Med 19 (2004) 813-818
26. Panerai A., Monza G., Movilia P., et al. A randomized, within-patient, cross-over, placebocontrolled trial on the efficacy and tolerability of the tricyclic antidepressants chlorimipramine and nortriptyline in central pain. Acta Neurol Scand 82 (1990) 34-38
27. Onghena P., and Van Houdenhove B. Antidepressant-induced analgesia in chronic non-malignant pain: A meta-analysis of 39 placebo-controlled studies. Pain 49 (1992) 205-219
28. GlaxoSmithKline. Paxil (paroxetine hydrochloride) Tablets and Oral Suspension: Prescribing information. http://us.gsk.com/products/assets/us_paxil.pdf Accessed June 1, 2008
29. Feighner J., and Boyer W. Paroxetine in the treatment of depression: A comparison with imipramine and placebo. J Clin Psychiatry 53 Suppl (1992) 44-47
30. Rickels K., Amsterdam J., Clary C., et al. The efficacy and safety of paroxetine compared with placebo in outpatients with major depression. J Clin Psychiatry 53 Suppl (1992) 30-32
31. Cohen J. Statistical Power Analysis for the Behavioral Sciences (1988), L. Erlbaum Associates, Hillsdale, NJ 8-14