Development and validation of a rapid and sensitive high-performance liquid chromatography-mass spectroscopy assay for determination of 17-(allylamino)-17-demethoxygeldanamycin and 17-(amino)-17-demethoxygeldanamycin in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 871, Issue 1, 2008, Pages 15-21

  Johnston, Jeffrey S ^a   Phelps, Mitch A ^a   Blum, Kristie A ^a   Blum, William ^a   Grever, Michael R ^a   Farley, Katherine L ^a   Dalton, James T ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

17 (Allylamino) 17 demethoxygeldanamycin; 17 (Amino) 17 demethoxygeldanamycin; 17AAG; 17AG; HSP90; LC MS MS

Indexed keywords

ACETIC ACID; ACETONITRILE; ADDITION REACTIONS; AMINATION; AMINES; ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; ATMOSPHERICS; CHEMICALS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; COLUMNS (STRUCTURAL); FATTY ACIDS; FLUIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; PLASMA (HUMAN); PLASMAS; PRESSURE; RATE CONSTANTS; STANDARDS;

(4-NITROPHENYL) ACETONITRILE; 17-DMAG; ACCURACY AND PRECISION; AGILENT (CO); ALLYLAMINO; ANALYTICAL METHODS; AND DETECTION; ATMOSPHERIC PRESSURE CHEMICAL IONIZATION (APCI); ELSEVIER (CO); GLACIAL ACETIC ACID (HAC); HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC); HPLC/MS/MS; HUMAN PLASMAS; INTERNAL STANDARD (IS); MASS SPECTROSCOPY (MS); NEGATIVE ION MODE; QUADRUPLE MASS SPECTROMETER (QMS); RETENTION TIMES; RUN TIME; SAMPLE ANALYSIS; SELECTED REACTION MONITORING; SENSITIVE METHODS; TANDEM MASS SPECTROSCOPY;

LIQUID CHROMATOGRAPHY;

ACETIC ACID; ACETONITRILE; DRUG METABOLITE; ERYTHROMYCIN DERIVATIVE; WATER;

ACCURACY; ANALYTIC METHOD; ARTICLE; ASSAY; ATMOSPHERIC PRESSURE; CONCENTRATION (PARAMETERS); FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IONIZATION; MASS SPECTROMETRY; MONITORING; PLASMA; PRIORITY JOURNAL; SAMPLE; STANDARD; VALIDATION STUDY;

BENZOQUINONES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HUMANS; LACTAMS, MACROCYCLIC; LEUKEMIA, MYELOID, ACUTE; MASS SPECTROMETRY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 48049089816     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.06.029     Document Type: Article

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