Multidrug-resistant, progressive, invasive diffuse spinal aspergillosis: Case report and review of the literature

Journal of Neurosurgical Sciences

Volumn 52, Issue 2, 2008, Pages 49-53

  Andaluz, N ^a   Zuccarello, M ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Drug resistance; Infection; Neuroaspergillosis; Thoracic vertebrae

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; ANTIFUNGAL AGENT; ANTINEOPLASTIC AGENT; CASPOFUNGIN; GADOLINIUM; ITRACONAZOLE; POSACONAZOLE; VORICONAZOLE;

ADULT; ANEMIA; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BACTERIUM CULTURE; BONE BIOPSY; BONE SCINTISCANNING; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER REGRESSION; CASE REPORT; CERVICAL SPONDYLOSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DISEASE COURSE; DISEASE SEVERITY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; HUMAN; HUMAN TISSUE; INTERVERTEBRAL DISK DISEASE; KIDNEY FAILURE; LUNG ASPERGILLOSIS; LUNG NON SMALL CELL CANCER; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; THORACIC SPINE;

AGED; ANTIFUNGAL AGENTS; ASPERGILLOSIS; CARCINOMA, SMALL CELL; DRUG RESISTANCE, MULTIPLE, FUNGAL; HUMANS; LUNG NEOPLASMS; MAGNETIC RESONANCE IMAGING; MALE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; SPINAL CORD DISEASES;

EID: 47949131387     PISSN: 00264881     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Pasqualotto AC, Denning AW. Postoperative aspergillosis. Clin Microbiol Infect 2006;12:1060-76.
2. Broner FA, Garland DE, Zigler JE: Spinal infections in the immunocompromised host. Orthop Clin North Am 1996;27:37-46.
3. Govender S, Kumar KP. Aspergillus spondylitis in immunocompetent patients. Int Orthop 2001;25:74-6.
4. Korovessis P, Repanti M, Katsardis T, Stamatakis M. Anterior decompression and fusion for aspergillus osteomyelitis of the lumbar spine associated with paraparesis. Spine 1994;19:2715-8.
5. Paterson DL. New clinical presentations of invasive aspergillosis in non-conventional hosts. Clin Microbiol Infect 2004;10(Suppl 1):24-30.
6. Vinas FC, King PK, Diaz FG. Spinal aspergillus osteomyelitis. Clin Infect Dis 1999;28:1223-9.
7. Abu Jawdeh L, Haidar R, Bitar F, Mroueh S, Akel S, Nuwayri-Salti N et al. Aspergillus vertebral osteomyelitis in a child with a primary monocyte killing defect: response to GM-CSF therapy. J Infect 200;41:97-100.
8. Dubbeld P, van Oostenbrugge RJ, Twinjstra A, Schouten HC. Spinal epidural abscess due to Aspergillus infection of the vertebrae: report of 3 cases. Neth J Med 1996;48:18-23.
9. Guermazi A, Gluckman E, Tabti B, Miaux Y. Invasive central nervous system aspergillosis in bone marrow transplantation recipients: an overview. Eur Radiol 2003;13:377-88.
10. Hummel M, Schuler S, Weber U, Schwertlick G, Hempel S, Theiss D. Aspergillosis with Aspergillus osteomyelitis and discitis after heart transplantation: surgical and medical management. J Heart Lung Transplant 1993;12:599-603.
11. Koh S, Ross LA, Gilles FH, Nelson MD Jr, Mitchell WG. Myelopathy resulting from invasive aspergillosis. Pediatr Neurol 1998;19:135-8.
12. Schubert M, Schar G, Curt A, Dietz V. Aspergillus spondylodiscitis in an immunocompetent paraplegic patient. Spinal Cord 1998;36:800-3.
13. Andriole VT. Infections with Aspergillus species. Clin Infect Dis 1993;17:S481-S486.
14. Salvalaggio PR, Bassetti M, Lorber MI, Micheletto GC, Friedman AL, Andriole VT et al. Aspergillus vertebral osteomyelitis after simultaneous kidney-pancreas transplantation. Transpl Infect Dis 2003;5:187-90.
15. Vaishya S, Sharma MS. Spinal Aspergillus vertebral osteomyelitis with extradural abscess: case report and review of literature. Surg Neurol 2004;61:551-5.
16. Saigal G, Donovan Post MJ, Kozic D. Thoracic intradural Aspergillus abscess formation following epidural steroid injection. AJNR 2004;25:642-4.
17. Martinez M, Lee AS, Hellinger WC, Kaplan J. Vertebral Aspergillus osteomyelitis and acute diskitis in patients with chronic obstructive pulmonary disease. Mayo Clin Proc 1999;74:579-83.
18. Dagirmanjian A, Schils J, McHenry M, Modic MT. MR imaging of vertebral osteomyelitis revisited. AJR 1996;167:1539-43.
19. Govender S, Rajoo R, Goga IE, Charles RW. Aspergillus osteomyelitis of the spine. Spine 1991;16:746-9.
20. Jack KS, Rhame FS, Brown B, Thompson RC. Aspergillus osteomyelitis - Report of four cases and review of the literature. Am J Med 1982;73:295-300.
21. Williams RL, Fukui MB, Meltzer CC, Swarnkar A, Johnson DW, Welch W. Fungal spinal osteomyelitis in the immunocompromised patient: MR findings in three cases. AJNR 1999;20:381-5.
22. Smith AS, Weinstein MA, Mizushima A, Coughlin B, Hayden SP, Lakin MM et al. MR imaging characteristics of tuberculous spondylitis vs vertebral osteomyelitis. AJNR 1989;10:619-25.
23. van Ooij A, Beckers JM, Herpers MJ, Walenkamp GH. Surgical treatment of aspergillus spondylodiscitis. Eur Spine J 2000;9:75-9.
24. Patterson TF. Treatment of invasive aspergillosis: polyenes, echinocanidins, or azoles? Med Mycol 2006;44(Suppl 1):357-62.
25. Witzig RS, Greer DL, Hyslop NE Jr. Aspergillus flavus mycetoma and epidural abscess successfully treated with itraconazole. J Med Vet Mycol 1996;34:133-7.
26. Howard SJ, Webster I, Moore CB, Gardiner RE, Park S, Perlin DS et al. Multi-azole resistance in aspergillus fumigatus. Int J Antimicrob Agents 2006;28:450-3.
27. Mellado E, Alcazar-Fuoli L, Garcia-Effron G, Alastruey-Izquierdo A, Cuenca-Estrella M, Rodriguez-Tudela JL. New resistance mechanisms to azole gdrugs in aspergillus fumigatus and emergence of antifungal drugs-resistant A. fumigatus atypical strains. Med Mycol 2006;44(Suppl 1):367-71.
28. Kontoyiannis DP, Hachem R, Lewis R, Rivero GA, Torres HA, ThornbyJ et al. Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignancies. Cancer 2003;98:292-9.
29. Steinbach WJ. Combination antifungal therapy for invasive aspergillosis-is it indicated? Med Mycol 2006;44(Suppl 1):373-82.