Perspectives on hormone replacement therapy: the Women's Health Initiative and new observational studies sampling the overall population

Fertility and Sterility

Volumn 90, Issue 2, 2008, Pages 258-264

  Tannen, Richard L ^a   Weiner, Mark G ^a   Xie, Dawei ^a   Barnhart, Kurt ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

cohort studies; coronary heart disease; Hormone replacement therapy; hysterectomy; menopause; randomized controlled trial

Indexed keywords

ESTROGEN;

BREAST CANCER; CLINICAL TRIAL; COLON CANCER; EDITORIAL; HORMONE SUBSTITUTION; HUMAN; HYSTERECTOMY; ISCHEMIC HEART DISEASE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; WOMEN'S HEALTH;

AGED; BREAST NEOPLASMS; COHORT STUDIES; COLONIC NEOPLASMS; CORONARY DISEASE; ESTROGEN REPLACEMENT THERAPY; FEMALE; HUMANS; HYSTERECTOMY; MIDDLE AGED; POPULATION SURVEILLANCE; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; WOMEN'S HEALTH;

EID: 47849126864     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2008.05.031     Document Type: Editorial

References (14)

1. Barnhart K.T., and Sammel M. The truth is out there: a guide to the pitfalls of interpreting evidence based medicine in studies of human reproduction. Fertil Steril 77 (2002) 223-228
2. Grodstein F., Stampfer M.J., Manson J.E., Colditz G.A., Willett W.C., Rosner B., et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. J Engl J Med 335 (1996) 453-461
3. Grodstein F., Manson J.E., Colditz G.A., Willett W.C., Speizer F.E., and Stampfel M.J. A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Ann Intern Med 133 (2000) 933-941
4. Hulley S., Grady D., Bush T., Furbert C., Herrington D., Riggss B., et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 280 (1998) 605-613
5. Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in health postmenopausal women. Principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
6. Grodstein F., Clarkson T.B., and Manson J.E. Understanding the divergent data on postmenopausal hormone therapy. N Engl J Med 348 (2003) 645-650
7. Women's Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. Women's Health Initiative Randomized Controlled Trial. JAMA 291 (2004) 1701-1712
8. Rossouw J.E., Prentice R.L., Manson J.E., Wu L., Barad D., Barnabei V.M., et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA 297 (2007) 1465-1477
9. Manson J.E., Matthew A.A., Rossouw J.E., Carr J., Langer R.D., Hsia J., et al. Estrogen therapy and coronary-artery calcification. N Engl J Med 356 (2007) 2591-2602
10. Tannen R.L., Weiner M.G., Xie D., and Barnhart K. A simulation using data from a primary care practice database closely replicated the women's health initiative trial. J Clin Epidemiol 60 (2007) 686-695
11. Weiner M.G., Barnhart K., Xie D., and Tannen R.L. Hormone replacement therapy and coronary heart disease in young women. Menopause 15 (2008) 86-93
12. Tannen R.L., Weiner M.G., Xie D., and Barnhart K. Estrogen affects post-menopausal women differently than estrogen plus progestin therapy. Hum Reprod 22 (2007) 1769-1777
13. Weiner MG, Xie D, Tannen RL. Replication of the Scandinavian Simvastatin Survival Study using a primary care medical record database prompted exploration of a new method to address unmeasured confounding. Pharmacoepidemiol Drug Saf. Published online March 10, 2008.
14. Tannen RL, Weiner MG, Xie D. Replicated studies of two randomized trials of angiotensin converting enzyme inhibitors: further empiric validation of the "prior event rate ratio" to adjust for unmeasured confounding by indication. Pharmacoepidemiol Drug Saf. Published online March 10, 2008.