2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Prevents Cardiac Valve Formation in Developing Zebrafish

Toxicological Sciences

Volumn 104, Issue 2, 2008, Pages 303-311

  Mehta, Vatsal ^a   Peterson, Richard E ^a,b   Heideman, Warren ^a,b  

^a Molecular and Environmental Toxicology Program   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

2,3,7,8 tetra chlorodibenzo p dioxin; Atrio ventricular valve; Blood regurgitation; Bulbo ventricular valve; Heart; Zebra fish

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; BONE MORPHOGENETIC PROTEIN 4; DIMETHYL SULFOXIDE; NOTCH1 RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD REGURGITATION; CELLULAR DISTRIBUTION; CIRCULATION; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; EMBRYOTOXICITY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE LOCATION; HEART ATRIOVENTRICULAR NODE; HEART DEVELOPMENT; MITRAL VALVE REGURGITATION; NONHUMAN; TOXIN ANALYSIS; TRICUSPID VALVE REGURGITATION; VALVULAR HEART DISEASE; ZEBRA FISH;

ANIMALS; AORTIC VALVE INSUFFICIENCY; BLOOD CIRCULATION; BONE MORPHOGENETIC PROTEINS; DISEASE MODELS, ANIMAL; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; ENVIRONMENTAL POLLUTANTS; HEART VALVES; IN SITU HYBRIDIZATION; MICROSCOPY, VIDEO; RECEPTOR, NOTCH1; RNA, MESSENGER; TERATOGENS; TETRACHLORODIBENZODIOXIN; ZEBRAFISH;

BULBUS; DANIO RERIO; TETRA;

EID: 47849106574     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn095     Document Type: Article

References (40)

1. Antkiewicz, D. S., Burns, C. G., Carney, S. A., Peterson, R. E., and Heideman, W. (2005). Heart malformation is an early response to TCDD in embryonic zebrafish. Toxicol. Sci. 84, 368-377.
2. Armstrong, E. J., and Bischoff, J. (2004). Heart valve development: Endothelial cell signaling and differentiation. Circ. Res. 95 459-470.
3. Bartman, T., Walsh, E. C., Wen, K. K., McKane, M., Ren, J., Alexander, J., Rubenstein, P. A., and Stainier, D. Y. (2004). Early myocardial function affects endocardial cushion development in zebrafish. PLoS Biol. 2, E129.
4. Beis, D., Bartman, T., Jin, S. W., Scott, I. C., D'Amico, L. A., Ober, E. A., Verkade, H., Frantsve, J., Field, H. A., Wehman, A., et al. (2005). Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development 132, 4193-4204.
5. Belair, C. D., Peterson, R. E., and Heideman, W. (2001). Disruption of erythropoiesis by dioxin in the zebrafish. Dev. Dyn. 222, 581-594.
6. Bello, S. M., Heideman, W., and Peterson, R. E. (2004). 2,3,7,8,-Tetrachlorodibenzo-p-dioxin inhibits regression of the common cardinal vein in developing zebrafish. Toxicol. Sci. 78, 258-266.
7. Carney, S. A., Chen, J., Burns, C. G., Xiong, K. M., Peterson, R. E., and Heideman, W. (2006). Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish. Mol. Pharmacol. 70, 549-561.
8. Chen, J. N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F. J., Furutani-Seiki, M., Granato, M., Hammerschmidt M., Heisenberg, C. P., et al. (1996). Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123, 293-302.
9. Cross, L. M., Cook, M. A., Lin, S., Chen, J. N., and Rubinstein, A. L. (2003). Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arterioscler. Thromb. Vasc. Biol. 23, 911-912.
10. Emmanouilides, G. C., Allen, H. D., Riemenschneider, T. A., and Gutgesell, H. P. (1998). Clinical Synopsis of Moss and Adams' Heart Disease in Infants, Children, and Adolescents. Williams and Wilkins, Baltimore, MD.
11. Enciso, J. M., Gratzinger, D., Camenisch, T. D., Canosa, S., Pinter, E., and Madri, J. A. (2003). Elevated glucose inhibits VEGF-A-mediated endocardial cushion formation: Modulation by PECAM-1 and MMP-2. J. Cell Biol. 160, 605-615.
12. Flanagan, T. C., and Pandit, A. (2003). Living artificial heart valve alternatives: A review. Eur. Cell. Mater. 6, 28-45; discussion 45
13. Goldberg, S. J., Lebowitz, M. D., Graver, E. J., and Hicks, S. (1990). An association of human congenital cardiac malformations and drinking water contaminants. J. Am. Coll. Cardiol. 16, 155-164.
14. Grego-Bessa, J., Diez, J., Timmerman, L., and de la Pompa, J. L. (2004). Notch and epithelial-mesenchyme transition in development and tumor progression: Another turn of the screw. Cell Cycle 3, 718-721.
15. Grimes, A. C., Stadt, H. A., Shepherd, I. T., and Kirby, M. L. (2006). Solving an enigma: Arterial pole development in the zebrafish heart. Dev. Biol. 290, 265-276.
16. Heid, S. E., Walker, M. K., and Swanson, H. I. (2001). Correlation of cardiotoxicity mediated by halogenated aromatic hydrocarbons to aryl hydrocarbon receptor activation. Toxicol. Sci. 61, 187-196.
17. Henry, T. R., Spitsbergen, J. M., Homung, M. W., Abnet, C. C., and Peterson, R. E. (1997). Early life stage toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish (Danio rerio). Toxicol. Appl. Pharmacol. 142, 56-68.
18. Hove, J. R., Koster, R. W., Forouhar, A. S., Acevedo-Bolton, G., Fraser, S. E., and Gharib, M. (2003). Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature 421, 172-177.
19. Hu, N., Sedmera, D., Yost, H. J., and Clark, E. B. (2000). Structure and function of the developing zebrafish heart. Anat. Rec. 260, 148-157.
20. Hurlstone, A. F., Haramis, A. P., Wienholds, E., Begthel, H., Korving, J., Van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R. H., and Clevers, H. (2003). The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature 425, 633-637.
21. Ivnitski, I., Elmaoued, R., and Walker, M. K. (2001). 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inhibition of coronary development is preceded by a decrease in myocyte proliferation and an increase in cardiac apoptosis. Teratology 64, 201-212.
22. Ivnitski-Steele, I. D., and Walker, M. K. (2003). Vascular endothelial growth factor rescues 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibition of coronary vasculogenesis. Birth Defects Res. A Clin. Mol. Teratol. 67, 496-503.
23. Jiao, K., Kulessa, H., Tompkins, K., Zhou, Y., Batts, L., Baldwin, H. S., and Hogan, B. L. (2003). An essential role of Bmp4 in the atrioventricular septation of the mouse heart. Genes Dev. 17 2362-2367.
24. Kuehl, K. S., and Loffredo, C. A. (2006). A cluster of hypoplastic left heart malformation in Baltimore, Maryland. Pediatr. Cardiol. 27 25-31.
25. Lee, R. K., Stainier, D. Y., Weinstein, B. M., and Fishman, M. C. (1994). Cardiovascular development in the zebrafish. II. Endocardial progenitors are sequestered within the heart field. Development 120, 3361-3366.
26. Milan, D. J., Giokas, A. C., Serluca, F. C., Peterson, R. T., and MacRae, C. A. (2006). Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development 133, 1125-1132.
27. Rottbauer, W., Wessels, G., Dahme, T., Just, S., Trano, N., Hassel, D., Burns, C. G., Katus, H. A., and Fishman, M. C. (2006). Cardiac myosin light chain-2: A novel essential component of thick-myofilament assembly and contractility of the heart. Circ. Res. 99, 323-331.
28. Scherz, P. J., Huisken, J., Sahai-Hernandez, P., and Stainier, D. Y. (2009). High-speed imaging of developing heart valves reveals interplay of morphogenesis and function. Development 135, 1179-1187.
29. Sehnert, A. J., Huq, A., Weinstein, B. M., Walker, C., Fishman, M., and Stainier, D. Y. (2002). Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nat. Genet. 31, 106-110.
30. Stainier, D. Y., Beis, D., Jungblut, B., and Bartman, T. (2002). Endocardial cushion formation in zebrafish. Cold Spring Harb. Symp. Quant. Biol. 67, 49-56.
31. Stainier, D. Y., Fouquet, B., Chen, J. N., Warren, K. S., Weinstein, B. M., Meiler, S. E., Mohideen, M. A., Neuhauss, S. C., Solnica-Krezel, L., Schier, A. F., et al. (1996). Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development 123, 285-292.
32. Stainier, D. Y., Lee, R. K., and Fishman, M. C. (1993). Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation. Development 119, 31-40.
33. Thackaberry, E. A., Jiang, Z., Johnson, C. D., Ramos, K. S., and Walker, M. K. (2005a). Toxicogenomic profile of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the murine fetal heart: Modulation of cell cycle and extracellular matrix genes. Toxicol. Sci. 88, 231-241.
34. Thackaberry, E. A., Nunez, B. A., Ivnitski-Steele, I. D., Friggins, M., and Walker, M. K. (2005b). Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on murine heart development: Alteration in fetal and postnatal cardiac growth, and postnatal cardiac chronotropy. Toxicol. Sci. 88, 242-249.
35. Thom, T., Haase, N., Rosamond, W., Howard, V. J., Rumsfeld, J., Manolio, T., Zheng, Z. J., Flegal, K., O'Donnell, C., Kittner, S., et al. (2006). Heart disease and stroke statistics-2006 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 113, e85-e151.
36. Timmerman, L. A., Grego-Bessa, J., Raya, A., Bertran, E., Perez-Pomares, J. M., Diez, J., Aranda, S., Palomo, S., McCormick, F., Izpisua-Belmonte, J. C., et al. (2004). Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 18, 99-115.
37. Vesely, I. (2005). Heart valve tissue engineering. Circ. Res. 97, 743-755.
38. Walsh, E. C., and Stainier, D. Y. (2001). UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Science 293 1670-1673.
39. Wang, W. D., Huang, C. J., Lu, Y. F., Hsin, J. P., Prabhakar, V. R., Cheng, C. F., and Hwang, S. P. (2006). Heart-targeted overexpression of Nip3a in zebrafish embryos causes abnormal heart development and cardiac dysfunction. Biochem. Biophys. Res. Commun. 347, 979-987.
40. Yelon, D. (2001). Cardiac patterning and morphogenesis in zebrafish. Dev. Dyn. 222, 552-563.