Long-term effects of folic acid fortification and B-vitamin supplementation on total folate, homocysteine, methylmalonic acid and cobalamin in older adults

Canadian Journal of Public Health

Volumn 99, Issue 5, 2008, Pages 428-433

  Garcia, Angeles A ^a,d   Day, Andrew G ^b   Zanibbi, Katherine ^a   Zunzunegui, Maria Victoria ^c  

^a QUEEN S UNIVERSITY   (Canada)

^b KINGSTON GENERAL HOSPITAL   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d St Mary's of the Lake Hospital   (Canada)

Author keywords

Aged; Cobalamin; Folate; Fortification; Homocysteine; Methylmalonic acid

Indexed keywords

EID: 47849101497     PISSN: 00084263     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03405255     Document Type: Article

References (32)

1. Canada Gazette Part II. SOR/98-550, 1998;132(24):3029-33.
2. Ray JG, Vermeulen MJ, Boss SC, Cole DEC. Declining rate of folate insufficiency among adults following increased folic acid food fortification in Canada. Can J Public Health 2002;93(4):249-53.
3. Selhub J, Jacques PF, Bostom AG, Wilson PW, Rosenberg IH. Relationship between plasma homocysteine and vitamin status in the Framingham study population. Impact of folic acid fortification. Public Health Rev 2000;28(1-4):117-45.
4. Choumenkovitch SF, Jacques PF, Nadeau MR, Wilson PW, Rosenberg IH, Selhub J. Folic acid fortification increases red blood cell folate concentrations in the Framingham study. J Nutr 2001;131(12):3277-80.
5. Hirsch S, de la Maza P, Barrera G, Gattas V, Petermann M, Bunout D. The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin-B12 deficiency in elderly people. J Nutr 2002;132(2):289-91.
6. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999;340(19): 1449-54.
7. Ray JG, Cole DEC, Boss SC. An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: Is a preventable public health issue on the rise? Clin Biochem 2000;33(5):337-43.
8. Jacques PF, Rosenberg IH, Rogers G, Selhub J, Bowman BA, Gunter EW, et al. Serum total homocysteine concentrations in adolescent and adult Americans: Results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr 1999;69(3):482-84.
9. Homocysteine Studies Collaboration. Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis. JAMA 2002;288(16):2015-22.
10. Graham IM, Daly LE, Refsum HM, Robinson K, Brattström LE, Ueland PM, et al. Plasma homocysteine as a risk factor for vascular disease. The European concerted action project. JAMA 1997;277(22):1775-81.
11. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346(7):476-83.
12. van Meurs JBJ, Dhonukshe-Rutten RAM, Pluijm SMF, van der Klift M, de Jonge R, Lindemans J, et al. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004;350(20):2033-41.
13. McLean RR, Jacques PF, Selhub J, Tucker KL, Samelson EJ, Broe KE, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004;350(20):2042-49.
14. Garcia A, Haron Y, Evans L, Smith MG, Freedman M, Roman GC. Metabolic markers of cobalamin deficiency and cognitive function in normal older adults. J Am Geriatr Soc 2004;52(1):66-71.
15. Garcia A, Haron Y, Pulman K, Hua L, Freedman M. Increases in homocysteine are related to worsening of Stroop scores in healthy elderly persons: A prospective follow-up study. J Gerontol A: Med Sci 2004;59(12):1323-27.
16. Ray JG. Folic acid fortification in Canada. Nutr Rev 2004;62(6 Pt 2):S35-39.
17. Allen RH, Stabler SP, Savage DG, Lindenbaum J. Diagnosis of cobalamin deficiency I: Usefulness of serum methylmalonic acid and total homocysteine concentrations. Am J Hematol 1990;34(2):90-98.
18. Stabler SP, Lindenbaum J, Allen RH. The use of homocysteine and other metabolites in the specific diagnosis of vitamin B-12 deficiency. J Nutr 1996;126(4 Suppl):1266S-72S.
19. Cleveland WS. Robust locally weighted regression and smoothing scatterplots. J Am Stat Assoc 1979;74(368):829-36.
20. SAS Institute Inc. The MIXED procedure. SAS/STAT users guide, version 8. Cary, NC: SAS Institute Inc., 1999; 2083-226.
21. Dunnett CW. New table for multiple comparisons with a control. Biometrics 1964;20(3):482-91.
22. Choumenkovitch SF, Selhub J, Wilson PW, Rader JI, Rosenberg IH, Jacques PF. Folic acid intake from fortification in the United States exceeds predictions. J Nutr 2002;132(9):2792-98.
23. Quinlivan EP, Gregory III JF. Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 2003;77(1):221-25.
24. Sisk ER, Lockner DW, Wold R, Waters DL, Baumgartner RN. The impact of folic acid fortification of enriched grains on an elderly population: The New Mexico aging process study. J Nutr Health Aging 2004;8(3):140-43.
25. Cole BF, Baron JA, Sandier RS, Haile RW, Ahnen DJ, Bresalier RS. Folic acid for the prevention of colorectal adenomas: A randomized clinical trial. JAMA 2007;297(21):2351-59.
26. Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, et al. A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: A hypothesis. Cancer Epidemiol Biomarkers Prev 2007;16(7):1325-29.
27. Arabelovic S, Sam G, Dallal GE, Jacques PF, Selhub J, Rosenberg IH, et al. Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritis. J Am Coll Nutr 2007;26(5):453-55.
28. Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85(1):193-200.
29. Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, et al. Reduction of plasma homocysteine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. N Engl J Med 1998;338(15):1009-15.
30. Tucker KL, Olson B, Bakun P, Dallal GE, Selhub J, Rosenberg IH. Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: A randomized trial. Am J Clin Nutr 2004;79(5):805-11.
31. Robertson J, Iemolo F, Stabler SP, Allen RH, Spence JD. Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products. CMAJ 2005;172(12):1569-73.
32. Ray JG, Vermeulen MJ, Langman LJ, Boss SC, Cole DEC. Persistence of vitamin B12 deficiency among elderly women after folic acid fortification. Clin Biochem 2003;36(5):387-91.