Automated quantitative dose-response modeling and point of departure determination for large toxicogenomic and high-throughput screening data sets

Toxicological Sciences

Volumn 104, Issue 2, 2008, Pages 412-418

  Burgoon, Lyle D ^a   Zacharewski, Timothy R ^a  

^a Toxicogenomic Informatics and Solutions LLC   (United States)

Author keywords

Bioinformatics; Biomarkers; Dose response; Mechanisms

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATION; BIOINFORMATICS; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE EXPRESSION; GENETIC MARKER; HIGH THROUGHPUT SCREENING; LIVER TOXICITY; MATHEMATICAL MODEL; MOUSE; NONHUMAN; OVARIECTOMY; PROBABILITY; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; SAFETY; TOXICOGENETICS;

ANIMALS; BENCHMARKING; BIOLOGICAL MARKERS; DATA INTERPRETATION, STATISTICAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OVARIECTOMY; RISK ASSESSMENT; TETRACHLORODIBENZODIOXIN; TOXICOGENETICS;

MUS;

EID: 47849100473     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn083     Document Type: Article

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