Experimental model of membranous nephropathy in mice: Sequence of histological and biochemical events

Laboratory Animals

Volumn 42, Issue 3, 2008, Pages 350-359

  Wu, Chia Chao ^a   Chen, Jin Shuen ^a   Lin, Shih Hua ^a   Chen, Ann ^a   Sytwu, Huey Kang ^a,b   Lin, Yuh Feng ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Animal model; Membranous nephropathy; Mouse; Proteinuria

Indexed keywords

BOVINE SERUM ALBUMIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G1 ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; FEMALE; GLOMERULUS BASEMENT MEMBRANE; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; HYPOALBUMINEMIA; IMMUNOFLUORESCENCE TEST; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LYMPHOCYTE SUBPOPULATION; MALE; MEMBRANOUS GLOMERULONEPHRITIS; METABOLISM; MOUSE; NONHUMAN; PROTEINURIA; SPLEEN CELL; SYMPTOM; TH2 CELL; TRANSGENIC MOUSE;

ANIMALS; BLOOD UREA NITROGEN; CREATININE; DISEASE MODELS, ANIMAL; FEMALE; GLOMERULONEPHRITIS, MEMBRANOUS; HISTOCYTOCHEMISTRY; HYPERCHOLESTEROLEMIA; HYPOALBUMINEMIA; IMMUNOGLOBULIN ISOTYPES; IMMUNOGLOBULINS; KIDNEY; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, ELECTRON, TRANSMISSION; PROTEINURIA; RANDOM ALLOCATION; SPECIFIC PATHOGEN-FREE ORGANISMS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

ANIMALIA; BOVINAE; MURINAE; MUS; MUS MUSCULUS;

EID: 47749154417     PISSN: 00236772     EISSN: None     Source Type: Journal    
DOI: 10.1258/la.2007.06016e     Document Type: Article

References (22)

1. Border WA, Ward HJ, Kamil ES, Cohen AH (1982) Induction of membranous nephropathy in rabbits by administration of an exogenous cationic antigen. Journal of Clinical Investigation 69, 451-61
2. Cattran DC (2001) Idiopathic membranous glomerulonephritis. Kidney International 59, 1983-94
3. Chen A, Sheu LF, Ho YS, et al. (1998) Experimental focal segmental glomerulosclerosis in mice. Nephron 78, 440-52
4. Chen JS, Chen A, Chang LC, et al. (2004) Mouse model of membranous nephropathy induced by cationic bovine serum albumin: antigen dose-response relations and strain differences. Nephrology, Dialysis, Transplantation 19, 2721-8
5. Couser WG, Abrass CK (1988) Pathogenesis of membranous nephropathy. Annual Review of Medicine 39, 517-30
6. Cunningham PN, Quigg RJ (2005) Contrasting roles of complement activation and its regulation in membranous nephropathy. Journal of the American Society of Nephrology 16, 1214-22
7. Cybulsky AV, Quigg RJ, Salant DJ (2005) Experimental membranous nephropathy redux. American Journal of Physiology. Renal Physiology 289, F660-71
8. Fleuren G, Grond J, Hoedemaeker PJ (1980) In situ formation of subepithelial glomerular immune complexes in passive serum sickness. Kidney International 17, 631-7
9. Glassock RJ (2003) Diagnosis and natural course of membranous nephropathy. Seminars in Nephrology 23, 324-32
10. Heymann W, Hackel DB, Harwood S, Wilson SG, Hunter JL (1959) Production of nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions. Proceedings of the Society for Experimental Biology and Medicine 100, 660-4
11. Kaplan C, Valdez JC, Chandrasekaran R, et al. (2002) Th1 and Th2 cytokines regulate proteoglycan-specific autoantibody isotypes and arthritis. Arthritis Research 4, 54-8
12. Kerjaschki D (2004) Pathomechanisms and molecular basis of membranous glomerulopathy. Lancet 364, 1194-6
13. Kerjaschki D, Farquhar MG (1982) The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proceedings of National Academy of Sciences of the United States of America 79, 5557-61
14. Kerjaschki D, Farquhar MG (1983) Immuno-cytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. Journal of Experimental Medicine 157, 667-86
15. Nangaku M, Shankland SJ, Couser WG (2005) Cellular response to injury in membranous nephropathy. Journal of the American Society of Nephrology 16, 1195-204
16. Ravnskov U (1998) The subepithelial formation of immune complexes in membranous glomerulonephritis may be harmless and secondary to toxic or allergic factors. Scandinavian Journal of Immunology 48, 469-74
17. Remuzzi G, Benigni A, Remuzzi A (2006) Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. Journal of Clinical Investigation 116, 288-96
18. Ronco P, Debiec H (2005) Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization. Journal of the American Society of Nephrology 16, 1205-13
19. Ruggenenti P, Chiurchiu C, Brusegan V, et al. (2003) Rituximab in idiopathic membranous nephropathy: a one-year prospective study. Journal of the American Society of Nephrology 14, 1851-7
20. Salant DJ, Quigg RJ, Cybulsky AV (1989) Heymann nephritis: mechanisms of renal injury. Kidney Internartional 35, 976-84
21. Snapper CM, Paul WE (1987) Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236, 944-7
22. Tipping PG, Kitching AR (2005) Glomerulonephritis, Th1 and Th2: what's new? Clinical and Experimental Immunology 142, 207-15