Effect of sertindole on QTc interval in patients with schizophrenia

Neuroscience Letters

Volumn 442, Issue 1, 2008, Pages 1-3

  Atmaca, Murad ^a   Yavuzkir, Mustafa ^a   Mermi, Osman ^a   Topuz, Mehtap ^a   Kanmaz, Ebru ^a   Tezcan, Ertan ^b  

^a FIRAT UNIVERSITY   (Turkey)

^b MALTEPE UNIVERSITY   (Turkey)

Author keywords

Prolongation; QTc; Schizophrenia; Sertindole

Indexed keywords

SERTINDOLE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EFFICACY; DRUG TOLERABILITY; ELECTROCARDIOGRAM; FEMALE; HUMAN; MALE; POSITIVE AND NEGATIVE SYNDROME SCALE; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; IMIDAZOLES; INDOLES; MALE; SCHIZOPHRENIA;

EID: 47749151020     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.05.065     Document Type: Article

References (15)

1. Andreasen N.C. Scale for the Assessment of Negative Symptoms (SANS) (1983), Department of Psychiatry College of Medicine, The University of Iowa
2. Andreasen N.C. Scale for the Assessment of Positive Symptoms (SAPS) (1983), Department of Psychiatry College of Medicine, The University of Iowa
3. Glassman A.H., and Bigger J.T. Antipsychotic drugs: prolonged QTc interval, torsades de pointes, and sudden death. Am. J. Psychiatry 158 (2001) 1774-1782
4. Heinrich T.W., Biblo L.A., and Schneider J. Torsades de pointes associated with ziprasidone. Psychosomatics 47 (2006) 264-268
5. Hennessy S., Bilker W.B., Knauss J.S., Margoli D.J., Kimmel S.E., Reynolds R.F., Glasser D.B., Morrison M.F., and Strom B.L. Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. BMJ 325 (2002) 1070-1074
6. Jouven X., Hagege A., Charron P., Carrier L., Dubourg O., Langlard J.M., Aliaga S., Bouhour J.B., Schwartz K., Desnos M., and Komajda M. Relation between QT duration and maximal wall thickness in familial hypertrophic cardiomyopathy. Heart 88 (2002) 153-157
7. Kelly H.G., Fay J.E., and Laverty S.G. Thioridazine hydrochloride (Mellaril): its effect on the electrocardiogram and a report of two fatalities with electrocardiographic abnormalities. Can. Med. Assoc. J. 89 (1963) 546-554
8. Lee S., Harris N.D., Robinson R.T., Yeoh L., Macdonald I.A., and Heller S.R. Effects of adrenaline and potassium on QTc interval and QT dispersion in man. Eur. J. Clin. Invest. 33 (2003) 93-98
9. Lindström E., and Levander S. Sertindole: efficacy and safety in schizophrenia. Expert Opin. Pharmacother. 13 (2006) 1825-1834
10. Mansi I.A., and Nash I.S. Ethnic differences in electrocardiographic intervals and axes. Electrocardiology 34 (2001) 303-307
11. Moss A.J. The QT interval and torsades de pointes. Drug Saf. 21 Suppl. 1 (1999) 5-10
12. Sertindole NDA 20-644, Rockville, MD, Food and Drug Administration, Psychopharmacological Drugs Advisory Committee, 1996.
13. Shin J.G., Kang W.-K., Shon J.H., Arefayene M., Yoon Y.R., Kim K.A., Kim D.I., Kim D.S., Cho K.H., Woosley R.L., and Flockhart D.A. Possible interethnic differences in quinidine-induced QT prolongation between healthy Caucasian and Korean subjects. Br. J. Clin. Pharmacol. 63 (2007) 206-215
14. Tay J.K.X., Tan C.H., Chong S.A., and Tan E.C. Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (2007) 1297-1302
15. Vitelli L.L., Crow R.S., Shahar E., Hutchinson R.G., Rautaharju P.M., and Folsom A.R. Electrocardiographic findings in a healthy biracial population, Atherosclerosis Risk Communities (ARIC) Study Investigation. Am. J. Cardiol. 81 (1998) 453