Cyclooxygenases and the pathogenesis of chronic rhinosinusitis and nasal polyposis

Current Allergy and Asthma Reports

Volumn 8, Issue 3, 2008, Pages 219-226

  Guilemany, Josep M ^b   Roca Ferrer, Jordi ^b   Mullol, Joaquim ^a  

^a HOSPITAL CLÍNIC   (Spain)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CORTICOSTEROID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 3; DIPYRONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 5; LEUKOTRIENE C4; LEUKOTRIENE C4 SYNTHASE; LEUKOTRIENE D4; LEUKOTRIENE E4; LIPOXYGENASE; MONTELUKAST; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PHENACETIN; PHOSPHOLIPASE A2; PRANLUKAST; PROSTACYCLIN; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN G2; PROSTAGLANDIN H2; PROSTAGLANDIN SYNTHASE; THROMBOXANE A2; THROMBOXANE B2; UNINDEXED DRUG; ZAFIRLUKAST; PROSTAGLANDIN;

ARACHIDONIC ACID METABOLISM; ASTHMA; CATALYSIS; CELLULAR IMMUNITY; CHRONIC SINUSITIS; CLINICAL TRIAL; DISEASE ASSOCIATION; DRUG HYPERSENSITIVITY; DRUG INDUCED DISEASE; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; HUMAN; INFLAMMATION; LOW DRUG DOSE; NOSE POLYP; NOSE SURGERY; PATHOGENESIS; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; REVIEW; RHINOSINUSITIS; RISK FACTOR; CHRONIC DISEASE; METABOLISM; PATIENT EDUCATION; PHYSIOLOGY; RHINITIS; SINUSITIS;

ARACHIDONIC ACID; CHRONIC DISEASE; HUMANS; LIPOXYGENASE; NASAL POLYPS; PATIENT EDUCATION AS TOPIC; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; RHINITIS; SINUSITIS;

EID: 47749137003     PISSN: 15297322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11882-008-0037-3     Document Type: Review

References (56)

1. Kaliner MA, Osguthorpe JD, Fireman P, et al.: Sinusitis: bench to bedside. Current findings, future directions. J Allergy Clin Immunol 1997, 99:829-848.
2. Gordts F, Clement PAR, Buisseret T: Prevalence of sinusitis signs in a non-ENT population. Otorhinolaryngology 1996, 58:315-319.
3. 3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. Rhinology 2007, s20:1-136.
4. Slavin RG: Nasal polyps and sinusitis. JAMA 1997, 278:1849-1854.
5. Bhattacharyya N: The role of infection in chronic rhinosinusitis. Curr Allergy Asthma Rep 2002, 2:500-506.
6. Zacharek MA, Krouse JH: The role of allergy in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg 2003, 11:196-200.
7. Jones NS: CT of the paranasal sinuses: a review of the correlations with clinical, surgical and histopathological findings. Clin Otolaryngol 2002, 27:11-17.
8. Steinke JW, Bradley D, Arango P, et al.: Cysteinyl leukotriene expression in chronic hyperplastic sinusitis-nasal polyposis: importance to eosinophilia and asthma. J Allergy Clin Immunol 2003, 111:342-349.
9. Dykewicz MS: Rhinitis and sinusitis. J Allergy Clin Immunol 2003, 111:520-529.
10. Bachert C, Van Cauwenberge PB: Inflammatory mechanisms in chronic sinusitis. Acta Otorhinolaryngol Belg 1997, 51:209-217.
11. Berger G, Kattan A, Bernheim J, Ophir D: Polypoid mucosa with eosinophilia and glandular hyperplasia in chronic sinusitis: a histopathological and immunohistochemical study. Laryngoscope 2002, 112:738-745.
12. Rudack C, Stoll W, Bachert C: Cytokines in nasal polyposis, acute and chronic sinusitis. Am J Rhinol 1998, 12:383-388.
13. Hamilos DL, Leung DY, Wood R, et al.: Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis. J Allergy Clin Immunol 1995, 96:537-544.
14. Benitez P, Alobid I, de Haro J, et al.: A short course of oral prednisone followed by intranasal budesonide is an effective treatment of severe nasal polyps. Laryngoscope 2006, 116:770-775.
15. Schmid M, Gode U, Schafer D, Wigand ME: Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics. Acta Otolaryngol 1999, 119:277-280.
16. Picado C, Fernandez-Morata JC, Juan M, et al.: Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. Am J Respir Care Med 1999, 160:291-296.
17. Szczeklik A, Nizankowska E, Duplaga M: Natural history of aspirin-induced asthma. AIANE Investigators. European Network on Aspirin-Induced Asthma. Eur Respir J 2000, 16:432-436.
18. ten Brinke A, Grootendorst DC, Schmidt JT, et al.: Chronic sinusitis in severe asthma is related to sputum eosinophilia. J Allergy Clin Immunol 2002, 109:621-626.
19. Alobid I, Benítez P, Bernal-Sprekelsen M, et al.: Nasal polyposis and its impact on quality of life. Comparison between the effects of medical and surgical treatments. Allergy 2005, 60:452-458.
20. Haave E, Hyland ME, Skumlien S: The relation between measures of health status and quality of life in COPD. Chron Respir Dis 2006, 3:195-199.
21. Roberts NJ, Lloyd-Owen SJ, Rapado F, et al.: Relationship between chronic nasal and respiratory symptoms in patients with COPD. Respir Med 2003, 97:909-914.
22. Guilemany JM, Mullol J, Picado C: Relation between rhinosinusitis and bronchiectasis. Arch Bronconeumol 2006, 42:135-140.
23. Guilemany JM, Alobid I, Angrill J, et al.: The impact of bronchiectasis associated to sinonasal disease on quality of life. Respir Med 2006, 100:1997-2003.
24. Chandrasekharan NV, Simmons DL: The cyclooxygenases. Genome Biol 2004, 5:241.
25. Nossaman BD, Baber SR, Nazim MM, et al.: Acetaminophen, phenacetin and dipyrone do not modulate pressor responses to arachidonic Acid or to pressor agents. Pharmacology 2007, 80:249-260.
26. Vancheri C, Mastruzzo C, Sortino MA, Crimi N: The lung as a privileged site for the beneficial actions of PGE2. Trends Immunol 2004, 25:40-46.
27. Capra V: Molecular and functional aspects of human cysteinyl leukotriene receptors. Pharmacol Res 2004, 50:1-11.
28. Ulualp SO, Sterman BM, Toohill RJ: Antileukotriene therapy for the relief of sinus symptoms in aspirin triad disease. Ear Nose Throat J 1999, 78:604-616.
29. Szczeklik A: The cyclooxygenase theory of aspirin-induced asthma. Eur Resp J 1990, 3:588-593.
30. Szczeklik A, Gryglewski RJ, Czerniawska-Mysik G: Relationship of inhibition of prostaglandin biosynthesis by analgesics to asthma attacks in aspirin-sensitive patients. Br Med J 1975, 1:67-69.
31. Pérez-Novo CA, Watelet JB, Claeys C, et al.: Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. J Allergy Clin Immunol 2005, 115:1189-1196.
32. Sanak M, Levy BD, Clish CB, et al.: Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. Eur Respir J 2000, 16:44-49.
33. Smith CM, Christie PE, Hawksworth RJ, et al.: Urinary leukotriene E4 levels after allergen and exercise challenge in bronchial asthma. Am Rev Respir Dis 1991, 144:1411-1413.
34. Parnes SM: The role of leukotriene inhibitors in patients with paranasal sinus disease. Curr Opin Otolaryngol Head Neck Surg 2003, 11:184-191.
35. Yamashita T, Tsuji H, Maeda N, et al.: Etiology of nasal polyps associated with aspirin-sensitive asthma. Rhinol Suppl 1989, 8:15-24.
36. Pinto S, Gallo O, Polli G, et al.: Cyclooxygenase and lipoxygenase metabolite generation in nasal polyps. Prostaglandins Leukot Essent Fatty Acids 1997, 57:533-537.
37. Gosepath J, Hoffmann F, Schäfer D, et al.: Aspirin intolerance in patients with chronic sinusitis. ORL J Otorhinolaryngol Relat Spec 1999, 61:146-150.
38. Kowalski ML, Pawliczak R, Wozniak J, et al.: Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. Am J Respir Crit Care Med 2000, 161:391-398.
39. Ziroli NE, Na H, Chow JM, et al.: Aspirin-sensitive versus non-aspirin-sensitive nasal polyp patients: analysis of leukotrienes/Fas and Fas-ligand expression. Otolaryngol Head Neck Surg 2002, 126:141-146.
40. Demoly P, Crampette L, Lebel B, et al.: Expression of cyclooxygenase 1 and 2 proteins in upper respiratory mucosa. Clin Exp Allergy 1998, 28:278-283.
41. J6ung TT, Juhn SK, Hwang D, Stewart R: Prostaglandins, leukotrienes, and other arachidonic acid metabolites in nasal polyps and nasal mucosa. Laryngoscope 1987, 97:84-89.
42. Schmid M, Gode U, Schafer D, Wigand ME: Arachidonic acid metabolism in nasal tissue and peripheral blood cells in aspirin intolerant asthmatics. Acta Otolaryngol 1999, 119:277-280.
43. Picado C, Fernandez-Morata JC, Juan M, et al.: Cyclooxygenase-2 mRNA is downexpressed in nasal polyps from aspirin-sensitive asthmatics. Am J Respir Care Med 1999, 160:291-296.
44. Mullol J, Fernàndez-Morata JC, Roca-Ferrer J, et al.: Cyclooxygenase 1 and cyclooxygenase 2 expression is abnormally regulated in human nasal polyps. J Allergy Clin Immunol 2002, 109:824-830.
45. Liu CM, Hong CY, Shun CT, et al.: Inducible cyclooxygenase and interleukin 6 gene expressions in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal polyposis. Arch Otolaryngol Head Neck Surg 2002, 128:945-951.
46. Picado C, Bioque G, Roca-Ferrer J, et al.: Nuclear factor-kappaB activity is down-regulated in nasal polyps from aspirin-sensitive asthmatics. Allergy 2003, 58:122-126.
47. Pujols L, Mullol J, Alobid I, et al.: Dynamics of COX-2 in nasal mucosa and nasal polyps from aspirin-tolerant and aspirin-intolerant patients with asthma. J Allergy Clin Immunol 2004, 114:814-819.
48. Gosepath J, Brieger J, Mann WJ: New immunohistologic findings on the differential role of cyclooxygenase 1 and cyclooxygenase 2 in nasal polyposis. Am J Rhinol 2005, 19:111-116.
49. Okano M, Fujiwara T, Yamamoto M, et al.: Role of prostaglandin D2 and E2 terminal synthases in chronic rhinosinusitis. Clin Exp Allergy 2006, 36:1028-1038.
50. Berges-Jimeno MP, Simon RA, Stevenson DD: Long-term treatment with aspirin desensitization in asthmatic patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol 2003, 111:180-186.
51. Stevenson DD, Pleskow WW, Simon RA, et al.: Aspirin-sensitive rhinosinusitis asthma: a double-blind crossover study of treatment with aspirin. J Allergy Clin Immunol 1984, 73:500-507.
52. Stevenson DD, Hankammer MA, Mathison DA, et al.: Aspirin desensitization treatment of aspirin-sensitive patients with rhinosinusitis-asthma: long-term outcomes. J Allergy Clin Immunol 1996, 98:751-758.
53. Nucera E, Schiavino D, Milani A, et al.: Effects of lysine-acetylsalicylate (LAS) treatment in nasal polyposis: two controlled long term prospective follow up studies. Thorax 2000, 55:S75-S78.
54. Parikh AA, Scadding GK: Intranasal lysine-aspirin in aspirin-sensitive nasal polyposis: a controlled trial. Laryngoscope 2005, 115:1385-1390.
55. Sestini P, Armetti L, Gambaro G, et al.: Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma. Am J Respir Crit Care Med 1996, 153:572-575.
56. Owens JM, Shroyer KR, Kingdom TT: Expression of cyclooxygenase and lipoxygenase enzymes in nasal polyps of aspirin-sensitive and aspirin-tolerant patients. Arch Otolaryngol Head Neck Surg 2006, 132:579-587.