Imaging and dosimetry of 99mTc EC annexin V: Preliminary clinical study targeting apoptosis in breast tumors

Applied Radiation and Isotopes

Volumn 66, Issue 9, 2008, Pages 1175-1182

  Kurihara, Hiroaki ^a   Yang, David J ^a   Cristofanilli, Massimo ^a   Erwin, William D ^a   Yu, Dong Fang ^a   Kohanim, Saady ^a   Mendez, Richard ^a   Kim, E Edmund ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

99mTc; Annexin V; Apoptosis; Breast cancer

Indexed keywords

CELLULAR EVENTS; EARLY DETECTION;

BIOLOGICAL MARKER; CYCLOPHOSPHAMIDE; CYSTEINE ETHYL ESTER TC 99M; DOXORUBICIN; ETHYLENEDICYSTEINE LIPOCORTIN 5 TECHNETIUM TC 99M; FLUOROURACIL; LIPOCORTIN 5; PACLITAXEL; TECHNETIUM 99M; DIAGNOSTIC AGENT; RADIOPHARMACEUTICAL AGENT; TECHNETIUM COMPLEX; TECHNETIUM TC 99M ETHYLENEDICYSTEINE ANNEXIN V;

ADULT; AGED; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INVASION; CANCER LOCALIZATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DOSIMETRY; EARLY DIAGNOSIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOTOPE LABELING; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RADIOISOTOPE DISTRIBUTION; SCINTIMAMMOGRAPHY; TREATMENT OUTCOME; BREAST TUMOR; CLINICAL TRIAL; DRUG EFFECT; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PROSPECTIVE STUDY; RADIOMETRY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYNTHESIS;

ADULT; AGED; ANNEXIN A5; APOPTOSIS; BREAST NEOPLASMS; FEMALE; HUMANS; MIDDLE AGED; ORGANOTECHNETIUM COMPOUNDS; PROSPECTIVE STUDIES; RADIOMETRY; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 47749122924     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2008.01.012     Document Type: Article

References (33)

1. Ando Y., Fukatsu H., Ishiguchi T., et al. Diagnostic utility of tumor vascularity on magnetic resonance imaging of the breast. Magn. Reson. Imag. 18 7 (2000) 807-813
2. Archer C.D., Parton M., Smith I.E., et al. Early changes in apoptosis and proliferation following primary chemotherapy for breast cancer. Br. J. Cancer 89 6 (2003) 1035-1041
3. Barker F.G., Chang S.M., Valk P.E., et al. 18-Fluorodeoxyglucose uptake and survival of patients with suspected recurrent malignant glioma. Cancer 79 1 (1997) 115-126
4. Bear H.D., Anderson S., Brown A., et al. The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: preliminary results from national surgical adjuvant breast and bowel project protocol B-27. J. Clin. Oncol. 21 22 (2003) 4165-4174
5. Blankenberg F.G., Robbins R.C., Stoot J.H., et al. Radionuclide imaging of acute lung transplant rejection with annexin V. Chest 117 3 (2000) 834-840
6. 18F-fluorodeoxyglucose metabolic imaging of tumors benefit oncology?. Eur. J. Nucl. Med. 24 6 (1997) 691-705
7. Buchholz T.A., Hunt K.K., Whitman G.J., et al. Neoadjuvant chemotherapy for breast carcinoma: multidisciplinary considerations of benefits and risks. Cancer 98 6 (2003) 1150-1160
8. Canet E.P., Casali C., Desenfant A., et al. Kinetic characterization of CMD-A2-Gd-DOTA as an intravascular contrast agent for myocardial perfusion measurement with MRI. Magn. Reson. Med. 43 3 (2000) 403-409
9. Cole B.F., Gelber R.D., Gelber S., et al. Polychemotherapy for early breast cancer: an overview of the randomised clinical trials with quality-adjusted survival analysis. Lancet 358 9278 (2001) 277-286
10. Denmeade S.R., and Isaacs J.T. Programmed cell death (apoptosis) and cancer chemotherapy: cancer control. Cancer Control 3 4 (1996) 303-309
11. Fisher B., Bryant J., Wolmark N., et al. Effect of preoperative chemotherapy on the outcome of women with operable breast cancer. J. Clin. Oncol. 16 8 (1998) 2672-2685
12. Goldsmith S.J. Receptor imaging: competitive or complementary to antibody imaging. Semin. Nucl. Med. 27 2 (1997) 85-93
13. Green M.C., Buzdar A.U., Smith T., et al. Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks. J. Clin. Oncol. 23 25 (2005) 5983-5992
14. Grigoriev M.Y., Pozharissky K.M., Hanson K.P., et al. Expression of caspase-3 and -7 does not correlate with the extent of apoptosis in primary breast carcinomas. Cell Cycle 1 5 (2002) 337-342
15. Hisada K., Tonami N., Kubo A., et al. A New Textbook of Clinical Nuclear Medicine. third ed (1999), Kanehara & Co. Ltd., Tokyo pp. 696-697
16. 99mTc-Ethylenedicysteine-Folate: a new tumor imaging agent. Synthesis, labeling and evaluation in animals. Cancer Biother. Radiopharm. 13 6 (1998) 427-435
17. Kihlstrom L., and Karlsson B. Imaging changes after radiosurgery for vascular malformations, functional targets, and tumors. Neurosurg. Clin. N. Am. 10 2 (1999) 167-180
18. Kumar S., Lennane J., and Ratner S. Argininosuccinate synthetase: essential role of cysteine and arginine residues in relation to structure and mechanism of ATP activation. Proc. Natl. Acad. Sci. USA 82 20 (1985) 6745-6749
19. Laissy J.P., Faraggi M., Lebtahi R., et al. Functional evaluation of normal and ischemic kidney by means of gadolinium-DOTA enhanced TurboFLASH MR imaging: a preliminary comparison with 99Tc-MAG3 dynamic scintigraphy. Magn. Reson. Imag. 12 3 (1994) 413-419
20. Mendelson M.T., Oestereicher N., Port P.L., et al. Breast density as a predictor of mammographic detection: comparison of interval and screen-detected cancers. J. Natl. Cancer Inst. 92 13 (2000) 1081-1087
21. Meyn R.E., Stephens L.C., Hunter N.R., et al. Induction of apoptosis in murine tumors by cyclophosphamide. Cancer Chem. Pharm. 33 5 (1994) 410-414
22. Meyn R.E., Stephens L.C., Hunter N.R., et al. Apoptosis in murine tumors treated with chemotherapy agents. Anti-Cancer Drugs 6 3 (1995) 443-450
23. Meyn R.E., Stephens L.C., Hunter N.R., et al. Kinetics of cisplatin-induced apoptosis in murine mammary and ovarian adenocarcinomas. Int. J. Cancer 60 5 (1995) 725-729
24. Nowak B., Di Martino E., Janicke S., et al. Diagnostic evaluation of malignant head and neck cancer by F-18-FDG PET compared to CT/MRI. Nuklearmedizin 38 8 (1999) 312-318
25. Ogura Y., Krams S.M., Martinez O.M., et al. Radiolabeled annexin V imaging: diagnosis of allograft rejection in an experimental rodent model of liver transplantation. Radiology 214 3 (2000) 795-800
26. Ohtsuki K., Akashi K., Aoka Y., et al. Technetium-99m HYNIC-annexin V: a potential radiopharmaceutical for the in-vivo detection of apoptosis. Eur. J. Nucl. Med. 26 10 (1999) 1251-1258
27. Pusztai L., Ayers M., Stec J., et al. Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors. Clin. Cancer Res. 9 7 (2003) 2406-2415
28. Shrinivas P., Abraham E., Ahamed I., et al. Apoptotic index: use in predicting recurrence in breast cancer patients. J. Exp. Clin. Cancer Res. 21 2 (2002) 233-238
29. Stabin M. MIRDose: the personal computer software for use in internal dose assessment in nuclear medicine. J. Nucl. Med. 37 3 (1996) 538-546
30. Verbruggen A., Nosco D., Van Nerom C., et al. Technetium-99m-L, l-ethylenedicysteine: a renal imaging agent. I. Labeling and evaluation in animals. J. Nucl. Med. 33 4 (1992) 551-557
31. Wheeler J.A., Stephens L.C., Tornos C., et al. ASTRO research fellowship: apoptosis as a predictor of tumor response to radiation in stage IB cervical carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 32 5 (1995) 1487-1493
32. 99mTc EC-annexin V. Cancer Biother. Radiopharm. 16 1 (2001) 73-84
33. 99mTc-ethylenedicysteine-colchicine for evaluation of antiangiogenic effect. Anti-Cancer Drugs 10 7 (1999) 685-692