APOE-ε4 polymorphism and cognitive deficit among the elderly population of Fernando de Noronha

Arquivos de Neuro-Psiquiatria

Volumn 66, Issue 2 B, 2008, Pages 298-302

  Garcia, Anália Nusya ^a   Da Silva, Helker Albuquerque ^a   Silva, Renan Carlos ^a   Leal, Eliane Maria Medeiros ^a   Rodrigues, Lorena ^a   Da Silva, Vanessa Cavalcante ^a   Dellalibera, Edileine ^c   Freitas, Elizabete Malaquias ^a   Ataíde Jr , Luiz ^b   Muniz, Maria Tereza Cartaxo ^a,d  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^c Hospital Universitario Oswaldo Cruz   (Brazil)

^d NONE   (Brazil)

Author keywords

APOE; Cognitive deficit; Elderly people; Polymorphism

Indexed keywords

APOLIPOPROTEIN E4; APOLIPOPROTEIN E4 EPSILON; GENOMIC DNA;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; BLOOD; CLOCK DRAWING TEST; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA ISOLATION; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; GERIATRIC ASSESSMENT; GERIATRIC PATIENT; GERONTOPSYCHIATRY; HUMAN; MAJOR CLINICAL STUDY; MALE; MINI MENTAL STATE EXAMINATION; NEUROPSYCHIATRY; NEUROPSYCHOLOGICAL TEST; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; VERBAL FLUENCY TEST; AGE; ANALYSIS OF VARIANCE; BRAZIL; BRIEF PSYCHIATRIC RATING SCALE; CHI SQUARE DISTRIBUTION; COGNITION; EDUCATIONAL STATUS; GENETICS; MIDDLE AGED; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; SEX DIFFERENCE;

AGE FACTORS; AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; APOLIPOPROTEIN E4; BRAZIL; BRIEF PSYCHIATRIC RATING SCALE; CHI-SQUARE DISTRIBUTION; COGNITION; COGNITION DISORDERS; EDUCATIONAL STATUS; FEMALE; GENOTYPE; GERIATRIC ASSESSMENT; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; SEX FACTORS;

EID: 47749099703     PISSN: 0004282X     EISSN: 16784227     Source Type: Journal    
DOI: 10.1590/S0004-282X2008000300002     Document Type: Article

References (37)

1. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 1999;56:303-308.
2. Huang W, Qui C, Von Struss E, Winblad B, Fratiglioni L. APOE genotype, family history of dementia and Alzheimer disease risk. Arch Neurol 2004;61:1930-1934.
3. Utermann G, Langenbeck U, Beisiegel U, Weber W. Genetics of the apolipoprotein E system in man. Am J Hum Genet 1980;32:339-347.
4. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
5. Greenwood PM, Lambert C, Sunderland T, Parasuraman R. Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results from the National Institute of Mental Health's BIOCARD study. Neuropsychology 2005;19:199-211.
6. Yip AG, Brayne C, Easton D, Rubisnsztein DC. Apolipoprotein E4 is only a weak predictor of dementia and cognitive decline in the general population. J Genet 2002;39:639-643.
7. Jack CR, Petersen RC, Xu Y-C, et al. Hippocampal atrophy and apolipoprotein E4 genotype are independently associated with Alzheimer's disease. Ann Neurol 1998;43:303-310.
8. Lehtovirta M, Laakso MP, Frisoni GB, Soininen H. How does the apolipoprotein E genotype modulate the brain in aging and in Alzheimer's disease? A review of neuroimaging studies. Neurobiol Aging 2000;21:293-300.
9. Parasuraman R, Greenwood PM, Sunderland T. The apolipoprotein E gene, attention, and brain function. Neuropsychology 2002;16:254-274.
10. Meyer MR, Tschanz JT, Norton MC, et al. APOE genotype predicts when - not whether - one is predisposed to develop Alzheimer disease. Nature Genet 1998;19:321-322.
11. Henderson AS, Easteal S, Jorm AF, et al. Apolipoprotein E allele 4, dementia, and cognitive decline in a population sample. Lancet. 1995;346:1387-1390.
12. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
13. Hixson, JE, Vernier DT. Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 1990;31:545-548.
14. Morris J. The clinical dementia rating (CDR): current version and scoring rules. Neurology 1993;43:2412-2414.
15. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984;34:939-944.
16. Folstein MF, Folstein SE, McHugh PR. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
17. Butters N, Granholm E, Salmon DP, et al. Episodic and semantic memory: a comparison of amnestic and demented patients. J Clin Exp Neuropsychol 9: 479-497.
18. Wolf-Klein GP, Silverstone FA, Levy AP, et al. Screening for Alzheimer's disease by clock drawing. J Am Geriatr Soc. 1989;37:730-734.
19. Hachinski VC, Iliff LD, Zilhka E, et al. Cerebral blood flow in dementia. Arch Neurol 1975;32:632-637.
20. Yesavage JA. Geriatric depression scale. Psychopharmacol Bull 1988;24:709-711.
21. McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathological diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop. Neurology 1996;47:1113-1124.
22. Herrera, HJ, Caramelli, P, Silveira, ASB, et al. R. Epidemiologic survey of dementia in a community- dwelling Brazilian population. Alzheimer Dis Assoc Dis 2002;16:103-108.
23. Corrêa ACO. Epidemiologia psicogeriátrica e uso de psicofármacos no Brasil. J Bras Psiq 1997;46:191-200.
24. Veras RP. Saúde Mental dos Idosos no Rio de Janeiro. In Almeida OP, Nitrini R (Eds). Demência. São Paulo: Fundo Editorial Byk, 1995:30-39.
25. Hedden T, Gabrielly JDE. Insights into the aging mind: a view from cognitive neuroscience. Nature Reviews Neuroscience 2004;5:87-97.
26. Brucki SMD, Rocha MSG. Category fluency test: effects of age, gender and education on total scores, clustering and switching in Brazilian Portuguese speaking subjects. Br J Med Biol Research 2004;37:1771-1777.
27. Xavier FMF, Argimon IIL, Zuppo L, et al. O desempenho em testes neuropsicológicos de octagenários não-dementes e com baixa escolaridade em duas comunidades do Sul do Brasil. PSICO Ψ 2006;37:221-231.
28. Brucki SMD, Nitrini R, Caramelli P, et al. Sugestões para o uso do mini-exame do estado mental no Brasil. Arq Neuropsiquiatr 2003;61:777-781.
29. Laks J, Baptista EM, Contino AL, Paula EO, Engelhardt E. Mini-mental state examination norms in a community-dwelling sample os elderly with low schooling in Brazil. Cad Saude Públ 2007;23:315-319.
30. Argimon IIL, Stein LM. Habilidades cognitivas em indivíduos muito idosos: um estudo longitudinal. Caderno Saúde Públ 2005;21:64-72.
31. Bertolucci PHF, Okamoto IH, Brucki SMD, et al. Applicability of the CERAD neuropsychological battery to Brazilian elderly. Arq Neuropsiquiatr 2001;59:532-536.
32. Engelhardt, E, Lacks J, Rozenthal M, et al. Idosos institucionalizados: rastreamento cognitivo. Rev Psiq Clin 1998;125:74-79.
33. Bertolucci PHF, Brucki SMD, Campacci SR, Juliano Y. O mini-exame do estado mental: impacto da escolaridade. Arq Neuropsiquiatr 1994;52: 1-7.
34. Brucki, SMD. Mini-exame do estado mental: influência da escolaridade sobre o escore total e subitens. Rev Neurociências 1996;4:15-20.
35. De-Andrade FM, Larrandaburu M, Callegari-Jacques SM, et al. Alzheimer's disease in a Southern Brazilian population. Braz. J Med Biol Res 2000;33:529-537.
36. Souza, DRS, Godoy MR, Hotta J, et al. Association of apolipoprotein E polymorphism in late-onset Alzheimer's disease and vascular dementia in Brazilians. Braz J Med Biol Res 2003;36:919-923.
37. Almeida OP, Shimokomaki CM. Apolipoprotein E4 and Alzheimer's disease in São Paulo - Brazil. Arq Neuropsiquiatr 1997;55:1-7.