Molecular mechanism of berberine's inhibitory effects on the apoptosis of NIT-1 cells induced by high glucose and saturated fatty acids

Chinese Pharmacological Bulletin

Volumn 24, Issue 6, 2008, Pages

  Sun, Huan ^a   Lu, Fu Er ^a   Wang, Zeng Si ^a   Xu, Li Jun ^a   Yang, Ming Wei ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Apoptosis; Berberine; NIT 1 cell line

Indexed keywords

BERBERINE; CASPASE 3; FATTY ACID; GLUCOSE; PROTEIN BAX; PROTEIN BCL 2; TETRAZOLIUM;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LABELING; CONTROLLED STUDY; CYTOPLASM; DRUG INHIBITION; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 47649120325     PISSN: 10011978     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Butler A E, Janson J, Bonner W S, et al. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes[J]. Diabetes, 2003,52:102-10.
2. Yun S L, Woo S K, Kang H K, et al. Berberine, a natural plant, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states[J]. Diabetes, 2006,55(8):2256-64.
3. Leng S H, Lu F E, Xu L J. Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion[J]. Acta Pharmacol Sin, 2004,25(4):496-502.
4. Federici M, Hribal M, Perego L, et al. High glucose causes apoptosis in cultured human pancreatic islets of langerhans[J]. Diabetes, 2001,50(6):1290-301.
5. Guo F, Zhu B Y, Chi X L, et al. Research of rosmarinic acid's inhibitory effects on the apoptosis of the vascular smooth muscle cell by hydrogen dioxide[J]. Chin Pharmacol Bull, 2007,23(3):365-70.
6. Springer J E, Nottingham S A, McEwen M L, et al. Caspase-3 apoptotic signaling following injury to the central nervous system[J]. Clin Chem Lab Med, 2001,39(4):299-307.
7. Thornberry N A, Lazebnik Y. Caspases: enemies within[J]. Science, 1998,281:1312-6.
8. Tanaka Y, Tran P O, Harmon J, et al. A role for glutathione perxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity[J]. Proc Natl Acad Sci USA, 2002,99:12363-8.
9. Bonnefont-Rousselot D, Bastard J P, Jaudon M C, et al. Consequences of the diabetic status on the oxidant/antioxidant balance[J]. Diabetes Metab, 2000,26:163-76.