Prolonged exposure to topical cyclosporine A does not seem to promote conjunctival malignancy

Acta Ophthalmologica

Volumn 86, Issue 4, 2008, Pages 462-

  Böhringer, Daniel ^a   Wojanowski, Bartosz ^b   Reinhard, Thomas ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN A; CYCLOSPORIN; EYE DROPS; IMMUNOSUPPRESSIVE AGENT;

ADENOVIRUS; CARCINOGENICITY; CATARACT; CHEMICAL CARCINOGENESIS; CONJUNCTIVA TUMOR; CONTROLLED STUDY; CORNEA OPACITY; DRUG EXPOSURE; FOLLOW UP; GLAUCOMA; HUMAN; IMPRESSION CYTOLOGY; LETTER; LONG TERM CARE; MAJOR CLINICAL STUDY; MALIGNANT TRANSFORMATION; PRIORITY JOURNAL; PUNCTATE KERATITIS; SLIT LAMP; TUMOR PROMOTION; CELL TRANSFORMATION; NOTE;

CELL TRANSFORMATION, NEOPLASTIC; CONJUNCTIVAL NEOPLASMS; CYCLOSPORINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; OPHTHALMIC SOLUTIONS;

EID: 47649105224     PISSN: 1755375X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0420.2007.01046.x     Document Type: Letter

References (5)

1. Heinz C, Fanihagh F & Steuhl KP (2003): Squamous cell carcinoma of the conjunctiva in patients with atopic eczema. Cornea 22: 135-137.
2. Hillenkamp J, Reinhard T, Ross RS et al. (2001): Topical treatment of acute adenoviral keratoconjunctivitis with 0.2% cidofovir and 1% cyclosporine: A controlled clinical pilot study. Arch Ophthalmol 119: 1487-1491.
3. Macarez R, Bossis S, Robinet A, Le Callonnec A, Charlin JF & Colin J (1999): Conjunctival epithelial neoplasias in organ transplant patients receiving cyclosporine therapy. Cornea 18: 495-497.
4. Reinhard T & Sundmacher R (1999): Topical cyclosporin A in Thygeson's superficial punctate keratitis. Graefes Arch Clin Exp Ophthalmol 237: 109-112.
5. Yarosh DB, Pena AV, Nay SL, Canning MT & Brown DA (2005): Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Invest Dermatol 125: 1020-1025.